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  1. Article ; Online: COVID-19 and Hepatic Artery Thrombosis: A Case Report.

    Antunes de Brito, Carlos Alexandre / de Oliveira Filho, José Ricardo Bandeira / Marques, Diogo Torres / Lencastre, Maria do Carmo / de Almeida, José Roberto / Lopes, Edmundo Pessoa

    The American journal of case reports

    2021  Volume 22, Page(s) e932531

    Abstract: ... events have also been reported. This case report describes a patient with COVID-19 and abdominal pain ... who developed coagulopathy and a rare association of hepatic artery thrombosis. Common hepatic artery thrombosis ... reports show gastrointestinal involvement. This report of a rare association of hepatic artery thrombosis ...

    Abstract BACKGROUND Hypercoagulable states, including venous and arterial thromboses, manifesting as pulmonary thromboembolism or stroke have been observed in COVID-19; recently, gastrointestinal thrombotic events have also been reported. This case report describes a patient with COVID-19 and abdominal pain, who developed coagulopathy and a rare association of hepatic artery thrombosis. Common hepatic artery thrombosis is usually observed among liver transplantation patients and has not been described in infectious disease. CASE REPORT A 45-year-old woman presented in the Emergency Department with a nonproductive cough, sore throat, asthenia, headache, myalgia, anosmia, and dysgeusia. On the 5th day after the onset of these symptoms, she tested positive for SARS-COV-2 and was managed with symptomatic drugs. Although her initial symptoms of COVID-19 improved progressively, on the 14th day she experienced acute abdominal pain. On the 16th day, she was hospitalized and administered intravenous analgesia. Abdominal computed tomography angiography revealed partial thrombosis in the common hepatic artery, which was confirmed by liver Doppler ultrasonography. Protein C and D-dimer levels peaked during this period. Serum tests for thrombophilia were negative. Subcutaneous enoxaparin (60 mg twice daily) was administered during hospitalization, and her abdominal pain improved significantly. She was discharged after 3 days and prescribed an oral anticoagulant for the next 30 days. CONCLUSIONS Thrombotic events are well-recognized complications of COVID-19 and recent reports show gastrointestinal involvement. This report of a rare association of hepatic artery thrombosis highlights the importance of investigating the thrombotic events in patients with abdominal pain and coagulopathy during COVID-19.
    MeSH term(s) COVID-19 ; Enoxaparin ; Female ; Hepatic Artery/diagnostic imaging ; Humans ; Middle Aged ; SARS-CoV-2 ; Thrombosis/drug therapy ; Thrombosis/etiology
    Chemical Substances Enoxaparin
    Language English
    Publishing date 2021-08-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.932531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Acute Liver Failure after Treatment with Rivaroxaban for Aortic Thrombosis Associated with COVID-19 Infection and Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T).

    Jukic, Ivana / Bozic, Dorotea / Lalovac, Milos / Pavicic Ivelja, Mirela / Radic, Mislav / Sundov, Zeljko / Vukovic, Jonatan

    Case reports in gastroenterology

    2022  Volume 16, Issue 2, Page(s) 320–325

    Abstract: ... to severe arterial thrombotic complications. In the case of severe COVID-19 infection, hepatic dysfunction ... thrombosis associated with COVID-19 infection and methylenetetrahydrofolate reductase gene polymorphism ... Coronavirus disease-2019 (COVID-19) has become associated with prothrombotic state that could lead ...

    Abstract Coronavirus disease-2019 (COVID-19) has become associated with prothrombotic state that could lead to severe arterial thrombotic complications. In the case of severe COVID-19 infection, hepatic dysfunction has been observed in more than 50% of patients. In this article, we present a case of aortic thrombosis associated with COVID-19 infection and methylenetetrahydrofolate reductase gene polymorphism (C677T) treated with rivaroxaban resulting in acute liver failure with fatal outcome.
    Language English
    Publishing date 2022-05-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2440540-1
    ISSN 1662-0631
    ISSN 1662-0631
    DOI 10.1159/000524791
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  3. Article: Acute liver failure after vaccination against of COVID-19; a case report and review literature.

    Sohrabi, Masoudreza / SobheRakhshankhah, Elham / Ziaei, Hosein / AtaeeKachuee, Manizhe / Zamani, Farhad

    Respiratory medicine case reports

    2021  Volume 35, Page(s) 101568

    Abstract: ... Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination ... Background: Vaccination against COVID-19 remains as a main root of COVID-19 prevention ... been reported as a rare side effect after ChAdox1nCOV-19 vaccination that may cause death of recipient ...

    Abstract Background: Vaccination against COVID-19 remains as a main root of COVID-19 prevention. Few vaccines have been launched for this purpose recently with different side effects. Thrombotic events have been reported as a rare side effect after ChAdox1nCOV-19 vaccination that may cause death of recipient.
    Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination by ChAdOx1nCov-19. The patient was a health care worker, aged 34-year old. Past medical history was unremarkable and had not used heparin. Over the next couple of days after the vaccination, he reported headache, nausea, and dizziness as well as abdominal pain. His general status and the laboratories studies deteriorate quickly by increasing liver enzymes and severe coagulopathy. Clinically he had presented acute hepatic failure. He had been received blood products, prednisolone pulse along with broad antibiotics without benefit. He died on the sixth day.
    Conclusions: Thrombotic events after vaccination is very rare but can develop in main arteries with lethal outcome. This event may mimic autoimmune thrombosis clinically.
    Language English
    Publishing date 2021-12-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2021.101568
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  4. Article ; Online: High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data.

    Díaz, Luis Antonio / Idalsoaga, Francisco / Cannistra, Macarena / Candia, Roberto / Cabrera, Daniel / Barrera, Francisco / Soza, Alejandro / Graham, Rondell / Riquelme, Arnoldo / Arrese, Marco / Leise, Michael D / Arab, Juan Pablo

    World journal of gastroenterology

    2021  Volume 26, Issue 48, Page(s) 7693–7706

    Abstract: ... patients of any age and COVID-19 diagnosis based on a molecular test. Histopathological reports ... We identified 18 studies from 7 countries; all were case reports and case series from autopsies ... on hepatic histopathological findings in COVID-19 is scarce.: Aim: To characterize hepatic pathological ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) disease can frequently affect the liver. Data on hepatic histopathological findings in COVID-19 is scarce.
    Aim: To characterize hepatic pathological findings in patients with COVID-19.
    Methods: We conducted a systematic review with meta-analysis registered on PROSPERO (CRD42020192813), following PRISMA guidelines. Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test. Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed. Articles including less than ten patients were excluded. Proportions were pooled using random-effects models.
    Results: We identified 18 studies from 7 countries; all were case reports and case series from autopsies. All the patients were over 15 years old, and 67.2% were male. We performed a meta-analysis of 5 studies, including 116 patients. Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1% [95% confidence interval (CI): 46.2-63.8], congestion of hepatic sinuses 34.7% (95%CI: 7.9-68.4), vascular thrombosis 29.4% (95%CI: 0.4-87.2), fibrosis 20.5% (95%CI: 0.6-57.9), Kupffer cell hyperplasia 13.5% (95%CI: 0.6-54.3), portal inflammation 13.2% (95%CI: 0.1-48.8), and lobular inflammation 11.6% (95%CI: 0.3-35.7). We also identified the presence of venous outflow obstruction, phlebosclerosis of the portal vein, herniated portal vein, periportal abnormal vessels, hemophagocytosis, and necrosis.
    Conclusion: We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features. Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation. Further studies are needed to establish the mechanisms and implications of these findings.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/virology ; Fatty Liver/epidemiology ; Fatty Liver/etiology ; Fatty Liver/pathology ; Hepatic Veins/pathology ; Humans ; Kupffer Cells/pathology ; Liver/blood supply ; Liver/cytology ; Liver/pathology ; Prevalence ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity ; Venous Thrombosis/epidemiology ; Venous Thrombosis/etiology ; Venous Thrombosis/pathology
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v26.i48.7693
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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  5. Article ; Online: Splanchnic venous thrombosis in a nephrotic patient following COVID-19 infection: a case report.

    Hussein, Maged H / Alabdaljabar, Mohamad S / Alfagyh, Noorah / Badran, Mohammad / Alamiri, Khalid

    BMC nephrology

    2021  Volume 22, Issue 1, Page(s) 420

    Abstract: Background: As the COVID-19 pandemic spread worldwide, case reports and small series identified ... Conclusion: Our case highlights the potential for a catastrophic outcome when COVID-19 infection occurs ... been reported in COVID-19 infected patients in spite of their number exceeding 180 million worldwide ...

    Abstract Background: As the COVID-19 pandemic spread worldwide, case reports and small series identified its association with an increasing number of medical conditions including a propensity for thrombotic complications. And since the nephrotic syndrome is also a thrombophilic state, its co-occurrence with the SARS-CoV-2 infection is likely to be associated with an even higher risk of thrombosis, particularly in the presence of known or unknown additional risk factors. Lower extremity deep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of COVID-19-associated hypercoagulable state with other venous or arterial sites being much less frequently involved. Although splanchnic vein thrombosis (SVT) has been reported to be 25 times less common than usual site venous thromboembolism (VTE) and rarely occurs in nephrotic patients, it can have catastrophic consequences. A small number of SVT cases have been reported in COVID-19 infected patients in spite of their number exceeding 180 million worldwide.
    Case presentation: An unvaccinated young adult male with steroid-dependent nephrotic syndrome (SDNS) who was in a complete nephrotic remission relapsed following contracting SARS-CoV-2 infection and developed abdominal pain and diarrhea. Abdominal US revealed portal vein thrombosis. The patient was anticoagulated, yet the SVT rapidly propagated to involve the spleno-mesenteric, intrahepatic and the right hepatic veins. In spite of mechanical thrombectomy, thrombolytics and anticoagulation, he developed mesenteric ischemia which progressed to gangrene leading to bowel resection and a complicated hospital course.
    Conclusion: Our case highlights the potential for a catastrophic outcome when COVID-19 infection occurs in those with a concomitant hypercoagulable state and reminds us of the need for a careful assessment of abdominal symptoms in SARS-CoV-2 infected patients.
    MeSH term(s) COVID-19/complications ; Gangrene/etiology ; Humans ; Intestines/pathology ; Male ; Mesenteric Ischemia/etiology ; Mesenteric Ischemia/therapy ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/drug therapy ; Portal System ; SARS-CoV-2 ; Splanchnic Circulation ; Venous Thrombosis/etiology ; Venous Thrombosis/therapy ; Young Adult
    Language English
    Publishing date 2021-12-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-021-02643-0
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  6. Article ; Online: Case Report: COVID-19 Associated Renal Infarction and Ascending Aortic Thrombosis.

    Mukherjee, Aveek / Ghosh, Raisa / Furment, Marlene Marte

    The American journal of tropical medicine and hygiene

    2020  Volume 103, Issue 5, Page(s) 1989–1992

    Abstract: ... with 2 weeks of fever, cough, and shortness of breath and was diagnosed with COVID-19 pneumonia ... He required readmission due to worsened hypoxia and was later found to have left renal artery thrombosis ... Following its discovery in Wuhan, China, in December 2019, COVID-19 has attained pandemic status ...

    Abstract Following its discovery in Wuhan, China, in December 2019, COVID-19 has attained pandemic status in mere months. It is caused by SARS-CoV-2, an enveloped beta coronavirus. This infection causes a prothrombogenic state by interplay of inflammatory mediators, and endothelial, microvascular, and possible hepatic damage and tissue tropism of the virus. This leads to frequent pulmonary and cerebral thromboembolism as well as occasional involvement of other organs. We present a 71-year-old man who initially presented with 2 weeks of fever, cough, and shortness of breath and was diagnosed with COVID-19 pneumonia. He required readmission due to worsened hypoxia and was later found to have left renal artery thrombosis with left kidney infarction, associated with an ascending aortic thrombus. He was anticoagulated and recovered uneventfully. We suggest that physicians have a high degree of suspicion to diagnose and manage the novel manifestations of this disease.
    MeSH term(s) Aged ; Aorta/pathology ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Humans ; Infarction/virology ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Renal Artery/pathology ; SARS-CoV-2 ; Thrombosis/virology
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-0869
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.61: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Case Report: COVID-19 Associated Renal Infarction and Ascending Aortic Thrombosis

    Mukherjee, Aveek / Ghosh, Raisa / Furment, Marlene Marte

    Am J Trop Med Hyg

    Abstract: ... with 2 weeks of fever, cough, and shortness of breath and was diagnosed with COVID-19 pneumonia ... He required readmission due to worsened hypoxia and was later found to have left renal artery thrombosis ... Following its discovery in Wuhan, China, in December 2019, COVID-19 has attained pandemic status ...

    Abstract Following its discovery in Wuhan, China, in December 2019, COVID-19 has attained pandemic status in mere months. It is caused by SARS-CoV-2, an enveloped beta coronavirus. This infection causes a prothrombogenic state by interplay of inflammatory mediators, and endothelial, microvascular, and possible hepatic damage and tissue tropism of the virus. This leads to frequent pulmonary and cerebral thromboembolism as well as occasional involvement of other organs. We present a 71-year-old man who initially presented with 2 weeks of fever, cough, and shortness of breath and was diagnosed with COVID-19 pneumonia. He required readmission due to worsened hypoxia and was later found to have left renal artery thrombosis with left kidney infarction, associated with an ascending aortic thrombus. He was anticoagulated and recovered uneventfully. We suggest that physicians have a high degree of suspicion to diagnose and manage the novel manifestations of this disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #761004
    Database COVID19

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