Article ; Online: Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.
The Yale journal of biology and medicine
2016 Volume 89, Issue 1, Page(s) 5–21
Abstract: ... While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system ... activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and ... Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious ...
| Abstract | Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen postmortem. While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and likely forms neurotoxic pores has led to a new paradigm regarding why past therapeutics may have failed and how to design the next round of compounds for clinical trials. An atomic resolution understanding of Aβ aggregates, which appear to exist in multiple conformations, is most desirable for future therapeutic development. The investigative difficulties, structures of these small Aβ aggregates, and current therapeutics are summarized in this review. |
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| MeSH term(s) | Alzheimer Disease/metabolism ; Amyloid beta-Peptides/chemistry ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/chemistry ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Humans ; Membrane Microdomains/metabolism | |||||
| Chemical Substances | Amyloid beta-Peptides ; Amyloid beta-Protein Precursor | |||||
| Language | English | |||||
| Publishing date | 2016-03-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 200515-3 | |||||
| ISSN | 1551-4056 ; 0044-0086 | |||||
| ISSN (online) | 1551-4056 | |||||
| ISSN | 0044-0086 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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