LIVIVO - Search results -

Search results

Result 1 - 8 of total 8

Search options

Article ; Online: COVID-19 presentations and outcome in patients with epilepsy.

Asadi-Pooya, Ali A / Emami, Amir / Akbari, Ali / Javanmardi, Fatemeh

2021 Volume 143, Issue 6, Page(s) 624–628

Abstract: ... 9.8% in PWE and 8.5% in people without epilepsy; p = 0.690].: Conclusion: Patients with epilepsy ... in a very large cohort of patients with COVID-19. We also investigated whether COVID-19 is associated ... epilepsy. Seizures were significantly more frequent among PWE as a presenting manifestation of COVID-19 ...

Abstract	Objective: To determine whether patients with epilepsy (PWE) are particularly over-represented in a very large cohort of patients with COVID-19. We also investigated whether COVID-19 is associated with a different clinical picture or a more severe course of illness in PWE (compared with others). Methods: All consecutive patients who referred to and admitted at healthcare facilities anywhere in Fars province (located in the south of Iran with a population of 4,851,000 people) from February 19, 2020 until November 20, 2020 were included. Results: A total of 37,968 patients were studied. Eighty-two patients (0.2%) had pre-existing epilepsy. Seizures were significantly more frequent among PWE as a presenting manifestation of COVID-19 compared with that in people without epilepsy (Odds Ratio = 27; p = 0.0001). Furthermore, PWE less often reported cough (significantly) and more often had gastrointestinal symptoms (vomiting and anorexia; as trends) compared with those in people without epilepsy. Patients with epilepsy were not differently likely to be intubated or admitted at ICUs. Case fatality rates were not different between the two groups [9.8% in PWE and 8.5% in people without epilepsy; p = 0.690]. Conclusion: Patients with epilepsy are not susceptible to contracting COVID-19 more than other individuals. Furthermore, COVID-19 in PWE is not associated with a more severe illness or a poorer prognosis. However, PWE and COVID-19 may present somewhat differently than others with such an illness. Why PWE less often present with cough and more often present with gastrointestinal symptoms is not clear yet and should be investigated and clarified in the future studies.
MeSH term(s)	Adult ; COVID-19/epidemiology ; COVID-19/physiopathology ; Comorbidity ; Epilepsy/epidemiology ; Female ; Humans ; Iran/epidemiology ; Male ; Middle Aged ; Young Adult
Language	English
Publishing date	2021-02-16
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	90-5
ISSN	1600-0404 ; 0001-6314
ISSN (online)	1600-0404
ISSN	0001-6314
DOI	10.1111/ane.13404
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui I Zs.142: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: COVID-19 in Children with Down Syndrome

Journal of Clinical Medicine, Vol 10, Iss 5125, p

Data from the Trisomy 21 Research Society Survey

2021 Volume 5125

Abstract: ... of respiratory symptoms, fever, and several medical complications from COVID-19 than control patients without DS ... among paediatric COVID-19 patients with DS, and age and thyroid disorder were significant risk factors for acute ... respiratory distress syndrome. Mortality rates were low in all paediatric COVID-19 patients (with and ...

Abstract	Adults with Down Syndrome (DS) are at higher risk for severe outcomes of coronavirus disease 2019 (COVID-19) than the general population, but evidence is required to understand the risks for children with DS, which is necessary to inform COVID-19 shielding advice and vaccination priorities. We aimed to determine the epidemiological and clinical characteristics of COVID-19 in children with DS. Using data from an international survey obtained from a range of countries and control data from the United States, we compared the prevalence of symptoms and medical complications and risk factors for severe outcomes between DS and non-DS paediatric populations with COVID-19. Hospitalised COVID-19 patients <18 years with DS had a higher incidence of respiratory symptoms, fever, and several medical complications from COVID-19 than control patients without DS <18 years. Older age, obesity, and epilepsy were significant risk factors for hospitalisation among paediatric COVID-19 patients with DS, and age and thyroid disorder were significant risk factors for acute respiratory distress syndrome. Mortality rates were low in all paediatric COVID-19 patients (with and without DS), contrasting with previous findings in adults with DS (who exhibit higher mortality than those without DS). Children with DS are at increased risk for more severe presentations of COVID-19. Efforts should be made to ensure the comprehensive and early detection of COVID-19 in this population and to identify children with DS who present comorbidities that pose a risk for a severe course of COVID-19. Our results emphasize the importance of vaccinating children with DS as soon as they become eligible.
Keywords	COVID-19 ; Down Syndrome ; paediatrics ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Exploring seizure management in hospitals, unmet need, and the impact of the COVID-19 pandemic on seizure presentations to hospital.

Ellis, Bethan / Chilcott, Ellie / John, Keri / Parry, Julie / Capeling, Louise / Lawthom, Charlotte / Harding, Katharine / Anderson, Joseph

Seizure

2022 Volume 102, Page(s) 51–53

Abstract: ... of admissions during the Covid-19 pandemic, referrals to acute neurology and the epilepsy team remained low ... to the adult epilepsy team (32%). Patients with active significant mental health concerns were significantly ... Outcomes in patients with learning disabilities, active significant mental health concerns, and ...

Abstract	Purpose: This study assesses investigations, referrals and admissions in patients presenting to the Emergency Department (ED) with seizures, and the effect of the COVID-19 pandemic on such management. Outcomes in patients with learning disabilities, active significant mental health concerns, and from the most socioeconomically deprived areas were compared to those of the general cohort. Methods: Investigations, referrals and admissions were recorded for 120 patients across two cohorts; pre-pandemic (September 2019) and during the pandemic (December 2020). Retrospective review of individual patient electronic health care records was used for data collection. Results: There was a decrease in patient numbers from 2019 to 2020. A greater proportion of patients presented with organic cause seizures and fewer presented with non-epileptic attacks. Frequent use of CT heads (45%) is likely to represent improper use of limited resources. There were low referral rates, both to acute neurology (28%) and to the adult epilepsy team (32%). Patients with active significant mental health concerns were significantly less likely to be referred to neurology or admitted. Conclusions: Despite a greater proportion of admissions during the Covid-19 pandemic, referrals to acute neurology and the epilepsy team remained low. Failure to refer prevents the most vulnerable seizure patients from receiving appropriate support, as seen in patients with active significant mental health concerns. Neurology staff were unaware of a significant number of patients presenting with seizures, which is of concern in an already over-stretched department. This offers an opportunity to improve care for people with epilepsy.
MeSH term(s)	Adult ; Humans ; Pandemics ; COVID-19/epidemiology ; Seizures/diagnosis ; Seizures/epidemiology ; Seizures/therapy ; Epilepsy/diagnosis ; Epilepsy/epidemiology ; Epilepsy/therapy ; Hospitals ; Emergency Service, Hospital ; Retrospective Studies
Language	English
Publishing date	2022-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2022.09.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3573: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Rapidly evolving Creutzfeldt-Jakob disease in COVID-19: from early status epilepticus to fatal outcome.

Olivo, Sasha / Furlanis, Giovanni / Buoite Stella, Alex / Fabris, Martina / Milanic, Romina / Zanusso, Gianluigi / Manganotti, Paolo

Acta neurologica Belgica

2022 Volume 123, Issue 4, Page(s) 1553–1556

Abstract: ... from admission. First EEG presented continuous diffuse spikes, sharp waves and sharp-and-slow wave complexes ... for others microorganism infections, and how the diagnosis might be more challenging due to its uncommon ... a fulminant CJD evolution associated with SARS-CoV-2 infection, which led to patient death after 15 days ...

Abstract	We report the case of a 70-year-old man coming to our attention for new onset refractory status epilepticus (NORSE) in a rapidly evolving CJD during SARS-CoV-2 co-infection. Our case report describes a fulminant CJD evolution associated with SARS-CoV-2 infection, which led to patient death after 15 days from admission. First EEG presented continuous diffuse spikes, sharp waves and sharp-and-slow wave complexes, pattern consistent with a non-convulsive status epilepticus (NORSE). Our case supports how CJD with SARS-CoV-2 co-infection could be characterized by an accelerated evolution, as already hypothesize for others microorganism infections, and how the diagnosis might be more challenging due to its uncommon presentations, such as NORSE.
MeSH term(s)	Male ; Humans ; Aged ; Creutzfeldt-Jakob Syndrome/complications ; Creutzfeldt-Jakob Syndrome/diagnosis ; Fatal Outcome ; Coinfection/complications ; Electroencephalography ; COVID-19/complications ; SARS-CoV-2 ; Status Epilepticus/etiology
Language	English
Publishing date	2022-07-19
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-02023-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui I Zs.57: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Non-COVID Neurological Emergencies: A Silent Killer Going Unnoticed during COVID-19 Pandemic

Dhar, Nikita / Madhaw, Govind / Kumar, Mritunjai / Kumar, Niraj / Tiwari, Ashutosh / Jatale, Vinayak

Journal of Neurosciences in Rural Practice

2021 Volume 12, Issue 03, Page(s) 461–469

Abstract: ... in stroke and delay in hospitalization in SE.: Conclusion: COVID-19 pandemic and associated lockdown ... and single center study involving 295 patients with neurological emergencies mainly including acute ... Presenting patients had comparatively severe illness with increased requirement of MV ( p < 0.001) and ...

Abstract	Objective: This study assesses the impact of coronavirus disease 2019 (COVID-19) on the pattern of neurological emergencies reaching a tertiary care center. Materials and Methods: This is a retrospective and single center study involving 295 patients with neurological emergencies mainly including acute stroke, status epilepticus (SE), and tubercular meningitis visiting emergency department (ED) from January 1 to April 30, 2020 and divided into pre- and during lockdown, the latter starting from March 25 onward. The primary outcome was number of neurological emergencies visiting ED per week in both periods. Secondary outcomes included disease severity at admission, need for mechanical ventilation (MV), delay in hospitalization, in-hospital mortality, and reasons for poor compliance to ongoing treatment multivariate binary logistic regression was used to find independent predictors of in-hospital mortality which included variables with p <0.1 on univariate analysis. Structural break in the time series analysis was done by using Chow test. Results: There was 53.8% reduction in number of neurological emergencies visiting ED during lockdown (22.1 visits vs. 10.2 visits per week, p = 0.001), significantly affecting rural population ( p = 0.004). Presenting patients had comparatively severe illness with increased requirement of MV ( p < 0.001) and significant delay in hospitalization during lockdown ( p < 0.001). Poor compliance to ongoing therapy increased from 34.4% in pre-lockdown to 64.7% patients during lockdown ( p < 0.001), mostly due to nonavailability of drugs ( p < 0.001). Overall, 35 deaths were recorded, with 20 (8.2%) in pre-lockdown and 15 (29.4%) during lockdown ( p = 0.001). Lockdown, nonavailability of local health care, delay in hospitalization, severity at admission, and need for MV emerged as independent predictors of poor outcome in stroke and delay in hospitalization in SE. Conclusion: COVID-19 pandemic and associated lockdown resulted in marked decline in non-COVID neurological emergencies reporting to ED, with more severe presentations and significant delay from onset of symptoms to hospitalization.
Keywords	COVID-19 ; lockdown ; stroke ; status epilepticus ; meningitis ; neurological emergencies
Language	English
Publishing date	2021-02-22
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2601242-X
ISSN	0976-3155 ; 0976-3147 ; 0976-3155
ISSN (online)	0976-3155
ISSN	0976-3147 ; 0976-3155
DOI	10.1055/s-0040-1722810
Database	Thieme publisher's database

Order via subito

Article: COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey.

Journal of clinical medicine

2021 Volume 10, Issue 21

Abstract	Adults with Down Syndrome (DS) are at higher risk for severe outcomes of coronavirus disease 2019 (COVID-19) than the general population, but evidence is required to understand the risks for children with DS, which is necessary to inform COVID-19 shielding advice and vaccination priorities. We aimed to determine the epidemiological and clinical characteristics of COVID-19 in children with DS. Using data from an international survey obtained from a range of countries and control data from the United States, we compared the prevalence of symptoms and medical complications and risk factors for severe outcomes between DS and non-DS paediatric populations with COVID-19. Hospitalised COVID-19 patients <18 years with DS had a higher incidence of respiratory symptoms, fever, and several medical complications from COVID-19 than control patients without DS <18 years. Older age, obesity, and epilepsy were significant risk factors for hospitalisation among paediatric COVID-19 patients with DS, and age and thyroid disorder were significant risk factors for acute respiratory distress syndrome. Mortality rates were low in all paediatric COVID-19 patients (with and without DS), contrasting with previous findings in adults with DS (who exhibit higher mortality than those without DS). Children with DS are at increased risk for more severe presentations of COVID-19. Efforts should be made to ensure the comprehensive and early detection of COVID-19 in this population and to identify children with DS who present comorbidities that pose a risk for a severe course of COVID-19. Our results emphasize the importance of vaccinating children with DS as soon as they become eligible.
Language	English
Publishing date	2021-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10215125
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: COVID-19-related encephalopathy: a case series with brain FDG-positron-emission tomography/computed tomography findings.

Delorme, C / Paccoud, O / Kas, A / Hesters, A / Bombois, S / Shambrook, P / Boullet, A / Doukhi, D / Le Guennec, L / Godefroy, N / Maatoug, R / Fossati, P / Millet, B / Navarro, V / Bruneteau, G / Demeret, S / Pourcher, V

European journal of neurology

2020 Volume 27, Issue 12, Page(s) 2651–2657

Abstract: ... was made in patients with confirmed COVID-19 who presented with new-onset cognitive disturbances ... manifestations, and one had status epilepticus. The delay between first COVID-19 symptoms and onset ... reported and studied.: Methods: We report four cases of COVID-19-related encephalopathy. The diagnosis ...

Abstract	Aim: The aim of this paper is to describe the clinical features of COVID-19-related encephalopathy and their metabolic correlates using brain 2-desoxy-2-fluoro-D-glucose (FDG)-positron-emission tomography (PET)/computed tomography (CT) imaging. Background and purpose: A variety of neurological manifestations have been reported in association with COVID-19. COVID-19-related encephalopathy has seldom been reported and studied. Methods: We report four cases of COVID-19-related encephalopathy. The diagnosis was made in patients with confirmed COVID-19 who presented with new-onset cognitive disturbances, central focal neurological signs, or seizures. All patients underwent cognitive screening, brain magnetic resonance imaging (MRI), lumbar puncture, and brain 2-desoxy-2-fluoro-D-glucose (FDG)-positron-emission tomography (PET)/computed tomography (CT) (FDG-PET/CT). Results: The four patients were aged 60 years or older, and presented with various degrees of cognitive impairment, with predominant frontal lobe impairment. Two patients presented with cerebellar syndrome, one patient had myoclonus, one had psychiatric manifestations, and one had status epilepticus. The delay between first COVID-19 symptoms and onset of neurological symptoms was between 0 and 12 days. None of the patients had MRI features of encephalitis nor significant cerebrospinal fluid (CSF) abnormalities. SARS-CoV-2 RT-PCR in the CSF was negative for all patients. All patients presented with a consistent brain FDG-PET/CT pattern of abnormalities, namely frontal hypometabolism and cerebellar hypermetabolism. All patients improved after immunotherapy. Conclusions: Despite varied clinical presentations, all patients presented with a consistent FDG-PET pattern, which may reflect an immune mechanism.
MeSH term(s)	Aged ; Brain Diseases/diagnostic imaging ; Brain Diseases/psychology ; Brain Diseases/therapy ; COVID-19/complications ; COVID-19/therapy ; Cerebellar Diseases/diagnostic imaging ; Cerebellar Diseases/etiology ; Cognition Disorders/etiology ; Cognition Disorders/psychology ; Female ; Fluorodeoxyglucose F18 ; Frontal Lobe/diagnostic imaging ; Humans ; Immunotherapy ; Magnetic Resonance Imaging ; Male ; Mental Disorders/etiology ; Mental Disorders/psychology ; Middle Aged ; Myoclonus/diagnostic imaging ; Myoclonus/etiology ; Neuropsychological Tests ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; Status Epilepticus/etiology ; Treatment Outcome
Chemical Substances	Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Keywords	covid19
Language	English
Publishing date	2020-09-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.14478
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 592: Show issues

Order via subito

Details ▾

Article: Non-COVID Neurological Emergencies: A Silent Killer Going Unnoticed during COVID-19 Pandemic

Kumar, Niraj

Journal of neurosciences in rural practice, 12(3):461-469

2021

Abstract: ... delay in hospitalization in SE. CONCLUSION: COVID-19 pandemic and associated lockdown resulted in marked ... patients had comparatively severe illness with increased requirement of MV (p < 0.001) and significant ... decline in non-COVID neurological emergencies reporting to ED, with more severe presentations and ...

Abstract	OBJECTIVE: This study assesses the impact of coronavirus disease 2019 (COVID-19) on the pattern of neurological emergencies reaching a tertiary care center. MATERIALS AND METHODS:This is a retrospective and single center study involving 295 patients with neurological emergencies mainly including acute stroke, status epilepticus (SE), and tubercular meningitis visiting emergency department (ED) from January 1 to April 30, 2020 and divided into pre- and during lockdown, the latter starting from March 25 onward. The primary outcome was number of neurological emergencies visiting ED per week in both periods. Secondary outcomes included disease severity at admission, need for mechanical ventilation (MV), delay in hospitalization, in-hospital mortality, and reasons for poor compliance to ongoing treatment multivariate binary logistic regression was used to find independent predictors of in-hospital mortality which included variables with p <0.1 on univariate analysis. Structural break in the time series analysis was done by using Chow test. RESULTS: There was 53.8% reduction in number of neurological emergencies visiting ED during lockdown (22.1 visits vs. 10.2 visits per week, p = 0.001), significantly affecting rural population (p = 0.004). Presenting patients had comparatively severe illness with increased requirement of MV (p < 0.001) and significant delay in hospitalization during lockdown (p < 0.001). Poor compliance to ongoing therapy increased from 34.4% in pre-lockdown to 64.7% patients during lockdown (p < 0.001), mostly due to nonavailability of drugs (p < 0.001). Overall, 35 deaths were recorded, with 20 (8.2%) in pre-lockdown and 15 (29.4%) during lockdown (p = 0.001). Lockdown, nonavailability of local health care, delay in hospitalization, severity at admission, and need for MV emerged as independent predictors of poor outcome in stroke and delay in hospitalization in SE. CONCLUSION: COVID-19 pandemic and associated lockdown resulted in marked decline in non-COVID neurological emergencies reporting to ED, with more severe presentations and significant delay from onset of symptoms to hospitalization.
Keywords	COVID-19 ; lockdown ; status epilepticus ; meningitis ; neurological emergencies ; stroke
Language	English
Document type	Article
Database	Repository for Life Sciences

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED