Article ; Online: Cerebrovascular Accident and SARS-CoV-19 (COVID-19): A Systematic Review.
2021 Volume 84, Issue 6, Page(s) 418–425
Abstract: ... of patients classified with mild or critical COVID-19 infection.: Discussion: The data suggest SARS-CoV-2 ... suggests an increased risk of cerebrovascular accident (CVA) in the setting of COVID-19 infection ... Methods: We searched 3 databases (PubMed, MEDLINE, and CINAHL) with search terms COVID-19, novel ...
| Abstract | Background: While the most common neurologic symptoms reported in patients affected by SARS-CoV-2 are headache, dizziness, myalgia, mental fog, and anosmia, there is a growing basis of published peer-reviewed cases reporting stroke in the setting of SARS-CoV-2 infection. The peer-reviewed literature suggests an increased risk of cerebrovascular accident (CVA) in the setting of COVID-19 infection. Methods: We searched 3 databases (PubMed, MEDLINE, and CINAHL) with search terms COVID-19, novel coronavirus, stroke, and cerebrovascular accident. Case series and case studies presenting patients positive for both COVID-19 and CVA published from January 1 through September 1, 2020, were included. Data collection and analysis was completed and risk of bias assessed. Results: The search identified 28 studies across 7 counties comprising 73 patients. Amongst patients hospitalized for COVID-19 infection and CVA, the average age was 60; the most common preexisting conditions were hypertension and diabetes mellitus, and those without preexisting conditions were significantly younger with an average age of 47. Amongst hospitalized patients with COVID-19 and CVA, there was a bimodal association with COVID-19 infection severity with majority of patients classified with mild or critical COVID-19 infection. Discussion: The data suggest SARS-CoV-2 is a risk factor for developing stroke, particularly in patients with hypertension and diabetes. Furthermore, the younger average age of stroke in patients with SARS-CoV-2, particularly those patients with zero identifiable preexisting conditions, creates high suspicion that SARS-CoV-2 is an independent risk factor for development of stroke; however, this cannot yet be proven without comparable control population. The data suggest the risk of developing CVA in the setting of COVID-19 infection is not dependent upon severity of illness. Continued studies must be done to understand the epidemiologic factors of COVID-19 infection and stroke and the pathophysiology of the COVID-associated hypercoagulable state. |
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| MeSH term(s) | COVID-19 ; Headache ; Humans ; Middle Aged ; SARS-CoV-2 ; Stroke/complications ; Stroke/epidemiology | |||||
| Language | English | |||||
| Publishing date | 2021-08-05 | |||||
| Publishing country | Switzerland | |||||
| Document type | Research Support, Non-U.S. Gov't ; Systematic Review | |||||
| ZDB-ID | 209426-5 | |||||
| ISSN | 1421-9913 ; 0014-3022 | |||||
| ISSN (online) | 1421-9913 | |||||
| ISSN | 0014-3022 | |||||
| DOI | 10.1159/000517403 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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