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Article ; Online: COVID-19 and Candida duobushaemulonii superinfection: A case report.

Awada, Bassem / Alam, Walid / Chalfoun, Maria / Araj, George / Bizri, Abdul Rahman

Journal de mycologie medicale

2021  Volume 31, Issue 3, Page(s) 101168

Abstract: ... to COVID-19 infection and developed Candida duobushaemulonii fungemia after multiple courses of antibiotics ... patients is scarce, and nonexistent regarding Candida duobushaemulonii superinfections.: Case description ... broad-spectrum antibiotics. Data regarding multidrug resistant (MDR) Candida species in COVID-19 ...

Abstract Introduction: Critically ill COVID-19 patients are at high risk for nosocomial bacterial and fungal infections due to several predisposing factors such as intensive care unit stay, mechanical ventilation, and broad-spectrum antibiotics. Data regarding multidrug resistant (MDR) Candida species in COVID-19 patients is scarce, and nonexistent regarding Candida duobushaemulonii superinfections.
Case description: A 34-year-old male presented to our institution with acute respiratory distress syndrome (ARDS) due to COVID-19 infection and developed Candida duobushaemulonii fungemia after multiple courses of antibiotics and prolonged mechanical ventilation. He died after recurrent pneumothorax led to respiratory failure and cardiac arrest.
Discussion: Bacterial and fungal infections are common complications of viral pneumonia in critically ill patients. Data regarding these infections in COVID-19 patients has been poorly studied with only a few cases reporting secondary infection, mostly without identifying specific pathogens. Prolonged hospital stays, invasive interventions (central venous catheter, mechanical ventilation), and the use of broad-spectrum antibiotics in COVID-19 infections could carry a high risk of bacterial and/or fungal superinfections.
Conclusion: Strategies to improve outcome in COVID-19 ICU patients should include early recognition of candidemia and appropriate antifungal therapy.
MeSH term(s) Adult ; Antifungal Agents/therapeutic use ; COVID-19/complications ; Candida ; Candidemia/complications ; Candidemia/drug therapy ; Fatal Outcome ; Humans ; Male ; Respiration, Artificial ; Respiratory Distress Syndrome ; Saccharomycetales ; Superinfection/complications ; Superinfection/drug therapy
Chemical Substances Antifungal Agents
Language English
Publishing date 2021-06-16
Publishing country France
Document type Case Reports ; Journal Article
ZDB-ID 1067006-3
ISSN 1773-0449 ; 1156-5233
ISSN (online) 1773-0449
ISSN 1156-5233
DOI 10.1016/j.mycmed.2021.101168
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