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  1. Article: Acute Renal Failure in a Patient With Severe Acute Respiratory Syndrome Coronavirus 2.

    Ayad, Sarah / Elkattawy, Sherif / Ejikeme, Chidinma / Al-Nasseri, Abraheim / Reddy, Aravinda

    Cureus

    2021  Volume 13, Issue 2, Page(s) e13406

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious viral pathogen ... mechanical ventilation. On top of worsening respiratory status, the patient developed new onset renal failure requiring ... organ failure. There is an increased incidence of acute kidney injury (AKI) in patients who become ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious viral pathogen with high morbidity and mortality rate. The infection affects multiple organ systems leading to systemic organ failure. There is an increased incidence of acute kidney injury (AKI) in patients who become critically ill. In the critical care setting, the incidence of AKI has been variable amongst different studies. Patients with acute kidney injury who progress to renal replacement therapy are associated with worse outcomes. We describe a case of a 42-year-old male who presented with hypoxemic respiratory failure secondary to SARS-CoV-2 associated pneumonia. The patient was initially managed with the nasal cannula and then required high flow nasal cannula with worsening hypoxemic respiratory failure, requiring invasive mechanical ventilation. On top of worsening respiratory status, the patient developed new onset renal failure requiring hemodialysis.
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.13406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection.

    Xiao, Yu / Qian, Kaiyu / Luo, Yongwen / Chen, Song / Lu, Mengxin / Wang, Gang / Ju, Lingao / Wang, Xinghuan

    European urology

    2020  Volume 78, Issue 2, Page(s) 298–299

    MeSH term(s) Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/enzymology ; Disease Transmission, Infectious/prevention & control ; Humans ; Pandemics ; Pneumonia, Viral/enzymology ; Renal Dialysis/methods ; Renal Insufficiency/epidemiology ; Renal Insufficiency/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-10
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.03.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection

    Xiao, Yu / Qian, Kaiyu / Luo, Yongwen / Chen, Song / Lu, Mengxin / Wang, Gang / Ju, Lingao / Wang, Xinghuan

    Eur Urol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #46201
    Database COVID19

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  4. Article ; Online: Re: Yu Xiao, Kaiyu Qian, Yongwen Luo, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.025.

    He, Peng / Wang, Xiaohui / Li, Hao

    European urology

    2020  Volume 78, Issue 1, Page(s) e25–e26

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Infections ; Pandemics ; Pneumonia, Viral ; Renal Insufficiency ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.04.041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Re: Yu Xiao, Kaiyu Qian, Yongwen Luo, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.025

    He, Peng / Wang, Xiaohui / Li, Hao

    Eur Urol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32345521
    Database COVID19

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  6. Article ; Online: Reply to Peng He, Xiaohui Wang, and Hao Li's Letter to the Editor re: Yu Xiao, Kaiyu Qian, Yongwen Luo, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.025.

    Xiao, Yu / Qian, Kaiyu / Luo, Yongwen / Chen, Song / Lu, Mengxin / Wang, Gang / Ju, Lingao / Wang, Xinghuan

    European urology

    2020  Volume 78, Issue 5, Page(s) e203–e204

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Male ; Pandemics ; Pneumonia, Viral ; Renal Insufficiency ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/diagnosis
    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Reply to Peng He, Xiaohui Wang, and Hao Li's Letter to the Editor re: Yu Xiao, Kaiyu Qian, Yongwen Luo, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Renal Failure Patients: A Potential Covert Source of Infection. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.025

    Xiao, Yu / Qian, Kaiyu / Luo, Yongwen / Chen, Song / Lu, Mengxin / Wang, Gang / Ju, Lingao / Wang, Xinghuan

    Eur Urol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #245729
    Database COVID19

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  8. Article ; Online: Kidney damage associated with COVID-19: from the acute to the chronic phase.

    Nlandu, Yannick / Tannor, Elliot Koranteng / Bafemika, Titilope / Makulo, Jean-Robert

    Renal failure

    2024  Volume 46, Issue 1, Page(s) 2316885

    Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection is well established ... with SARS-CoV-2 infection, in addition to acute kidney injury (AKI) as a transitional state with or ... enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predominance ...

    Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection is well established as a systemic disease including kidney damage. The entry point into the renal cell remains the angiotensin-converting enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predominance of structural and functional tubular lesions. The most common form of glomerular injury is collapsing glomerulopathy (CG), which is strongly associated with apolipoprotein L1(APOL-1) risk variants. These acute lesions, which are secondary to the direct or indirect effects of SARS-CoV-2, can progress to chronicity and are specific to long COVID-19 in the absence of any other cause. Residual inflammation associated with SARS-CoV-2 infection, in addition to acute kidney injury (AKI) as a transitional state with or without severe histological lesions, may be responsible for greater kidney function decline in mild-to-moderate COVID-19. This review discusses the evidence for renal histological markers of chronicity in COVID-19 patients and triggers of low-grade inflammation that may explain the decline in kidney function in the post-COVID-19 period.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Kidney/pathology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Inflammation/pathology
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2024.2316885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coincident Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy in COVID-19.

    Yılmaz Çebi, Aslıhan / Kılıçarslan, Oğuzhan / Uçar, Didar

    Turkish journal of ophthalmology

    2023  Volume 53, Issue 2, Page(s) 120–123

    Abstract: ... Chest computed tomography demonstrated pneumonia and two severe acute respiratory syndrome coronavirus 2 ... mL, respectively. The patient was diagnosed as having concurrent acute macular neuroretinopathy and ... polymerase chain reaction tests were positive. The patient had undergone renal transplantation 11 years ago due ...

    Abstract An ophthalmology consultation was requested for a 29-year-old woman complaining of visual field defects. The patient had presented to the emergency department with cough and high fever one day earlier. Chest computed tomography demonstrated pneumonia and two severe acute respiratory syndrome coronavirus 2 polymerase chain reaction tests were positive. The patient had undergone renal transplantation 11 years ago due to glomerulonephritis. Best-corrected visual acuity (BCVA) was 20/40 in the right eye and 20/30 in the left eye. Fluorescein angiography showed macular hypoperfusion, and optical coherence tomography (OCT) showed hyperreflectivity in the inner nuclear, outer plexiform, and outer nuclear layers, as well as discontinuity of the ellipsoid zone. Perimetry confirmed bilateral central scotoma. Levels of D-dimer and fibrinogen were 0.86 g/mL and 435.6 g/mL, respectively. The patient was diagnosed as having concurrent acute macular neuroretinopathy and paracentral acute middle maculopathy and was given low-molecular-weight heparin treatment for one month. Her BCVA improved to 20/20 in both eyes, and regression was observed in the retinal findings, hyperreflectivity and ellipsoid zone disruption on OCT, and scotoma in perimetry. Inflammation, thrombosis, and glial involvement may play a role in the pathogenesis of retinal microvascular impairment in COVID-19.
    MeSH term(s) Female ; Humans ; Adult ; Retinal Diseases/diagnosis ; Retinal Diseases/etiology ; COVID-19/complications ; Fluorescein Angiography/methods ; Scotoma/etiology ; Scotoma/complications ; White Dot Syndromes ; Macular Degeneration/complications
    Language English
    Publishing date 2023-04-23
    Publishing country Turkey
    Document type Case Reports ; Journal Article
    ZDB-ID 2586160-8
    ISSN 2149-8709 ; 2147-2661 ; 2149-8709 ; 1300-0659
    ISSN (online) 2149-8709
    ISSN 2147-2661 ; 2149-8709 ; 1300-0659
    DOI 10.4274/tjo.galenos.2022.55156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Outcomes of acute limb ischemia in COVID-19.

    Pham, Antoine / Heib, Adele / Goodman, Emily / Lipsitz, Evan / Indes, Jeffrey

    Journal of vascular surgery

    2022  Volume 76, Issue 4, Page(s) 1006–1013.e3

    Abstract: Objective: The inflammatory cascade caused by severe acute respiratory syndrome coronavirus 2 ... major adverse limb events (5.8% vs 2.9%; P = .0223), and acute renal failure (22.2% vs 14.9%; P = .0025 ... 27%; P = .0369), sepsis (16.9% vs 12.2%; P = .0288), acute renal failure (22.1% vs 14.6%; P = .0019 ...

    Abstract Objective: The inflammatory cascade caused by severe acute respiratory syndrome coronavirus 2 infection may result in arterial thrombosis and acute limb ischemia (ALI) with devastating consequences. The aims of this study were to compare outcomes of ALI in the lower extremities in patients with and without coronavirus disease 2019 (COVID-19), and to determine if ALI development in the context of COVID-19 portends a worse prognosis compared with COVID-19 without ALI.
    Methods: Queries were built on TriNetX, a federated network of health care organizations across the United States that provides de-identified patient data. International Classification of Diseases, 10th revision diagnostic codes were used to identify patients with acute limb ischemia of the lower extremities and COVID-19. The study timeframe was defined as January 20, 2020 to May 20, 2021. Statistical analyses, including propensity-score matching, were done through TriNetX's internal software. Outcomes looked at are rates of mortality, stroke, myocardial infarction, major adverse limb events, re-intervention, respiratory failure, sepsis, mental health complications, and acute renal failure. Baseline cohort characteristics were also collected.
    Results: Patients with ALI with COVID-19 (ALI C19+; n = 526) were significantly less likely than patients with ALI without COVID-19 (ALI; n = 14,131) to have baseline comorbidities, including nicotine dependence (18% vs 33%; P < .0001). In contrast, ALI C19+ patients had significantly more comorbidities than hospitalized patients with COVID-19 without ALI (n = 275,903), including nicotine dependence (18% vs 10%; P < .0001). After propensity matching was performed, ALI C19+ patients had significantly higher rates of mortality (24.9% vs 9.2%; P < .0001), major adverse limb events (5.8% vs 2.9%; P = .0223), and acute renal failure (22.2% vs 14.9%; P = .0025) than patients with ALI. Compared with hospitalized patients with COVID-19 without ALI, ALI C19+ patients had higher propensity-matched rates of respiratory failure and being placed on assisted ventilation (32.9% vs 27%; P = .0369), sepsis (16.9% vs 12.2%; P = .0288), acute renal failure (22.1% vs 14.6%; P = .0019), and mortality (24.7% vs 14.4%; P < .0001).
    Conclusions: Patients who developed ALI following COVID-19 present with significantly different demographics and comorbidities from those who develop ALI without COVID-19. After controlling for these variables, higher rates of major adverse limb events, acute renal failure, and mortality in patients with ALI with COVID-19 suggest that not only may COVID-19 precipitate ALI, but it may also exacerbate ALI sequelae. Furthermore, development of ALI in COVID-19 portends worse prognosis compared with patients with COVID-19 without ALI.
    MeSH term(s) Acute Disease ; Acute Kidney Injury ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Humans ; Ischemia/diagnosis ; Ischemia/therapy ; Lower Extremity ; Peripheral Vascular Diseases ; Respiratory Insufficiency ; Retrospective Studies ; Risk Factors ; Sepsis ; Time Factors ; Tobacco Use Disorder ; Treatment Outcome ; United States/epidemiology
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2022.04.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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