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  1. TI=Post covid syndrome in individuals admitted to hospital with covid 19: retrospective cohort study
  2. AU="Adli, Mazda"

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  1. Artikel ; Online: Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study.

    Ayoubkhani, Daniel / Khunti, Kamlesh / Nafilyan, Vahé / Maddox, Thomas / Humberstone, Ben / Diamond, Ian / Banerjee, Amitava

    BMJ (Clinical research ed.)

    2021  Band 372, Seite(n) n693

    Abstract: ... Retrospective cohort study.: Setting: NHS hospitals in England.: Participants: 47 780 individuals (mean ... uniform across ethnicities. The diagnosis, treatment, and prevention of post-covid syndrome requires ... Individuals discharged from hospital after covid-19 had increased rates of multiorgan dysfunction compared ...

    Abstract Objective: To quantify rates of organ specific dysfunction in individuals with covid-19 after discharge from hospital compared with a matched control group from the general population.
    Design: Retrospective cohort study.
    Setting: NHS hospitals in England.
    Participants: 47 780 individuals (mean age 65, 55% men) in hospital with covid-19 and discharged alive by 31 August 2020, exactly matched to controls from a pool of about 50 million people in England for personal and clinical characteristics from 10 years of electronic health records.
    Main outcome measures: Rates of hospital readmission (or any admission for controls), all cause mortality, and diagnoses of respiratory, cardiovascular, metabolic, kidney, and liver diseases until 30 September 2020. Variations in rate ratios by age, sex, and ethnicity.
    Results: Over a mean follow-up of 140 days, nearly a third of individuals who were discharged from hospital after acute covid-19 were readmitted (14 060 of 47 780) and more than 1 in 10 (5875) died after discharge, with these events occurring at rates four and eight times greater, respectively, than in the matched control group. Rates of respiratory disease (P<0.001), diabetes (P<0.001), and cardiovascular disease (P<0.001) were also significantly raised in patients with covid-19, with 770 (95% confidence interval 758 to 783), 127 (122 to 132), and 126 (121 to 131) diagnoses per 1000 person years, respectively. Rate ratios were greater for individuals aged less than 70 than for those aged 70 or older, and in ethnic minority groups compared with the white population, with the largest differences seen for respiratory disease (10.5 (95% confidence interval 9.7 to 11.4) for age less than 70 years
    Conclusions: Individuals discharged from hospital after covid-19 had increased rates of multiorgan dysfunction compared with the expected risk in the general population. The increase in risk was not confined to the elderly and was not uniform across ethnicities. The diagnosis, treatment, and prevention of post-covid syndrome requires integrated rather than organ or disease specific approaches, and urgent research is needed to establish the risk factors.
    Mesh-Begriff(e) Adult ; Aged ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/virology ; Cardiovascular Diseases/epidemiology ; Case-Control Studies ; Diabetes Mellitus/epidemiology ; England/epidemiology ; Ethnicity ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Middle Aged ; Multiple Organ Failure/epidemiology ; Patient Discharge/statistics & numerical data ; Patient Readmission/statistics & numerical data ; Respiratory Tract Diseases/epidemiology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification
    Sprache Englisch
    Erscheinungsdatum 2021-03-31
    Erscheinungsland England
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n693
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Developing a Long COVID Phenotype for Postacute COVID-19 in a National Primary Care Sentinel Cohort: Observational Retrospective Database Analysis.

    Mayor, Nikhil / Meza-Torres, Bernardo / Okusi, Cecilia / Delanerolle, Gayathri / Chapman, Martin / Wang, Wenjuan / Anand, Sneha / Feher, Michael / Macartney, Jack / Byford, Rachel / Joy, Mark / Gatenby, Piers / Curcin, Vasa / Greenhalgh, Trisha / Delaney, Brendan / de Lusignan, Simon

    JMIR public health and surveillance

    2022  Band 8, Heft 8, Seite(n) e36989

    Abstract: ... 13.5%, 95% CI 12.7-14.3) had a hospital admission related to acute COVID-19, and 6462 (86.5%, 95% CI ... to as postacute COVID-19 or long COVID (LC). LC varies from a single persisting symptom to a complex multisystem ... with unaffected people through retrospective research. This phenotype and study protocol to explore its face ...

    Abstract Background: Following COVID-19, up to 40% of people have ongoing health problems, referred to as postacute COVID-19 or long COVID (LC). LC varies from a single persisting symptom to a complex multisystem disease. Research has flagged that this condition is underrecorded in primary care records, and seeks to better define its clinical characteristics and management. Phenotypes provide a standard method for case definition and identification from routine data and are usually machine-processable. An LC phenotype can underpin research into this condition.
    Objective: This study aims to develop a phenotype for LC to inform the epidemiology and future research into this condition. We compared clinical symptoms in people with LC before and after their index infection, recorded from March 1, 2020, to April 1, 2021. We also compared people recorded as having acute infection with those with LC who were hospitalized and those who were not.
    Methods: We used data from the Primary Care Sentinel Cohort (PCSC) of the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) database. This network was recruited to be nationally representative of the English population. We developed an LC phenotype using our established 3-step ontological method: (1) ontological step (defining the reasoning process underpinning the phenotype, (2) coding step (exploring what clinical terms are available, and (3) logical extract model (testing performance). We created a version of this phenotype using Protégé in the ontology web language for BioPortal and using PhenoFlow. Next, we used the phenotype to compare people with LC (1) with regard to their symptoms in the year prior to acquiring COVID-19 and (2) with people with acute COVID-19. We also compared hospitalized people with LC with those not hospitalized. We compared sociodemographic details, comorbidities, and Office of National Statistics-defined LC symptoms between groups. We used descriptive statistics and logistic regression.
    Results: The long-COVID phenotype differentiated people hospitalized with LC from people who were not and where no index infection was identified. The PCSC (N=7.4 million) includes 428,479 patients with acute COVID-19 diagnosis confirmed by a laboratory test and 10,772 patients with clinically diagnosed COVID-19. A total of 7471 (1.74%, 95% CI 1.70-1.78) people were coded as having LC, 1009 (13.5%, 95% CI 12.7-14.3) had a hospital admission related to acute COVID-19, and 6462 (86.5%, 95% CI 85.7-87.3) were not hospitalized, of whom 2728 (42.2%) had no COVID-19 index date recorded. In addition, 1009 (13.5%, 95% CI 12.73-14.28) people with LC were hospitalized compared to 17,993 (4.5%, 95% CI 4.48-4.61; P<.001) with uncomplicated COVID-19.
    Conclusions: Our LC phenotype enables the identification of individuals with the condition in routine data sets, facilitating their comparison with unaffected people through retrospective research. This phenotype and study protocol to explore its face validity contributes to a better understanding of LC.
    Mesh-Begriff(e) COVID-19/complications ; COVID-19 Testing ; Humans ; Phenotype ; Primary Health Care ; Retrospective Studies ; Post-Acute COVID-19 Syndrome
    Sprache Englisch
    Erscheinungsdatum 2022-08-11
    Erscheinungsland Canada
    Dokumenttyp Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2369-2960
    ISSN (online) 2369-2960
    DOI 10.2196/36989
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Coronavirus Disease 2019 (COVID-19) and Venous Thromboembolism During Pregnancy and Postpartum.

    Bruno, Ann M / Horns, Joshua J / Metz, Torri D

    Obstetrics and gynecology

    2023  Band 143, Heft 1, Seite(n) 139–142

    Abstract: ... been completed. We performed a retrospective cohort study of individuals aged 18 years or older ... in nonobstetric patients with SARS-CoV-2 infection admitted to the hospital. National-level studies evaluating ... venous thromboembolism (VTE) among pregnant and postpartum individuals with and without SARS-CoV-2 infection have not ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with increased risk for macro- and micro-thrombi. Consensus guidelines recommend use of thromboprophylaxis in nonobstetric patients with SARS-CoV-2 infection admitted to the hospital. National-level studies evaluating venous thromboembolism (VTE) among pregnant and postpartum individuals with and without SARS-CoV-2 infection have not been completed. We performed a retrospective cohort study of individuals aged 18 years or older delivering at more than 20 weeks of gestation with data in the MarketScan Commercial Insurance Database from 2016 through 2020. Of 811,008 deliveries, SARS-CoV-2 infection during pregnancy or through 6 weeks postpartum was associated with increased risk for VTE compared with no infection (1.0% vs 0.5%, adjusted hazard ratio 2.62, 95% CI 1.60-4.29). Findings support further consideration of thromboprophylaxis in the obstetric population with SARS-CoV-2 infection.
    Mesh-Begriff(e) Pregnancy ; Female ; Humans ; COVID-19/epidemiology ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/prevention & control ; SARS-CoV-2 ; Retrospective Studies ; Anticoagulants/therapeutic use ; Postpartum Period ; Pregnancy Complications, Infectious/epidemiology
    Chemische Substanzen Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2023-09-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000005387
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  4. Artikel: Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

    Ayoubkhani, Daniel

    The BMJ, 372:n693

    2021  

    Abstract: ... Retrospective cohort study. SETTING: NHS hospitals in England. PARTICIPANTS: 47 780 individuals (mean age 65, 55 ... ethnicities. The diagnosis, treatment, and prevention of post-covid syndrome requires integrated rather ... days, nearly a third of individuals who were discharged from hospital after acute covid-19 were ...

    Abstract OBJECTIVE: To quantify rates of organ specific dysfunction in individuals with covid-19 after discharge from hospital compared with a matched control group from the general population. DESIGN: Retrospective cohort study. SETTING: NHS hospitals in England. PARTICIPANTS: 47 780 individuals (mean age 65, 55% men) in hospital with covid-19 and discharged alive by 31 August 2020, exactly matched to controls from a pool of about 50 million people in England for personal and clinical characteristics from 10 years of electronic health records. MAIN OUTCOME MEASURES: Rates of hospital readmission (or any admission for controls), all cause mortality, and diagnoses of respiratory, cardiovascular, metabolic, kidney, and liver diseases until 30 September 2020. Variations in rate ratios by age, sex, and ethnicity. RESULTS: Over a mean follow-up of 140 days, nearly a third of individuals who were discharged from hospital after acute covid-19 were readmitted (14 060 of 47 780) and more than 1 in 10 (5875) died after discharge, with these events occurring at rates four and eight times greater, respectively, than in the matched control group. Rates of respiratory disease (P<0.001), diabetes (P<0.001), and cardiovascular disease (P<0.001) were also significantly raised in patients with covid-19, with 770 (95% confidence interval 758 to 783), 127 (122 to 132), and 126 (121 to 131) diagnoses per 1000 person years, respectively. Rate ratios were greater for individuals aged less than 70 than for those aged 70 or older, and in ethnic minority groups compared with the white population, with the largest differences seen for respiratory disease (10.5 (95% confidence interval 9.7 to 11.4) for age less than 70 years v 4.6 (4.3 to 4.8) for age ≥70, and 11.4 (9.8 to 13.3) for non-white v 5.2 (5.0 to 5.5) for white individuals). CONCLUSIONS: Individuals discharged from hospital after covid-19 had increased rates of multiorgan dysfunction compared with the expected risk in the general population. The increase in risk was not confined to the elderly and was not uniform across ethnicities. The diagnosis, treatment, and prevention of post-covid syndrome requires integrated rather than organ or disease specific approaches, and urgent research is needed to establish the risk factors.
    Schlagwörter COVID-19
    Sprache Englisch
    Dokumenttyp Artikel
    Datenquelle Fachrepositorium Lebenswissenschaften

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