Article ; Online: Increasing high-density lipoprotein as a therapeutic target in atherothrombotic disease.
Revista espanola de cardiologia
2010 Volume 63, Issue 3, Page(s) 323–333
Abstract: ... epidemic. Both an elevated low-density lipoprotein (LDL) cholesterol level and a decreased high-density ... lipoprotein (HDL) cholesterol level are associated with the increased incidence of atherothrombosis. Reducing ... cardiovascular events. Therapies aimed at increasing HDL have been investigated for several decades ...
| Abstract | Unlabelled: Atherothrombosis, atherosclerosis and their thrombotic complications have become epidemic. Both an elevated low-density lipoprotein (LDL) cholesterol level and a decreased high-density lipoprotein (HDL) cholesterol level are associated with the increased incidence of atherothrombosis. Reducing LDL using statins has been shown to provide very effective therapy for both primary and secondary prevention. Nevertheless, despite statin treatment, a large percentage of patients continues to experience cardiovascular events. Therapies aimed at increasing HDL have been investigated for several decades, with promising Results: However, because statin treatment was not standardized in earlier trials, it has been difficult to draw clear Conclusions: Recent advances in both animal studies and clinical trials indicate that increasing the HDL level could result in additional benefits to those achieved by reducing LDL levels using statins. Intravenous infusion of various HDL preparations appears to lead to the accelerated regression and stabilization of atheromatous plaque, and could provide a novel approach to treatment in high-risk patients. This review describes the biological rationale underlying the use of treatments that increase HDL and discusses the potential benefits of such treatment. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Atherosclerosis/blood ; Atherosclerosis/complications ; Atherosclerosis/drug therapy ; Atherosclerosis/physiopathology ; Humans ; Lipoproteins, HDL/blood ; Lipoproteins, HDL/metabolism ; Thrombosis/blood ; Thrombosis/complications ; Thrombosis/drug therapy | |||||
| Chemical Substances | Lipoproteins, HDL | |||||
| Language | Spanish | |||||
| Publishing date | 2010-01-14 | |||||
| Publishing country | Spain | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 128925-1 | |||||
| ISSN | 1579-2242 ; 0300-8932 | |||||
| ISSN (online) | 1579-2242 | |||||
| ISSN | 0300-8932 | |||||
| DOI | 10.1016/s1885-5857(10)70065-7 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.B 215: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.