Article ; Online: Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages.
2019 Volume 11, Issue 4, Page(s) 316–329
Abstract: ... the potential of fmOMV as a prophylactic agent for the defense against influenza virus infection. ... on macrophages but independent of neutrophils. fmOMV induced recruitment and activation of macrophages and ... In this study, we investigated the protective effect of an attenuated bacterial outer membrane vesicle ...
| Abstract | Influenza A virus (IAV) poses a constant worldwide threat to human health. Although conventional vaccines are available, their protective efficacy is type or strain specific, and their production is time-consuming. For the control of an influenza pandemic in particular, agents that are immediately effective against a wide range of virus variants should be developed. Although pretreatment of various Toll-like receptor (TLR) ligands have already been reported to be effective in the defense against subsequent IAV infection, the efficacy was limited to specific subtypes, and safety concerns were also raised. In this study, we investigated the protective effect of an attenuated bacterial outer membrane vesicle -harboring modified lipid A moiety of lipopolysaccharide (fmOMV) against IAV infection and the underlying mechanisms. Administration of fmOMV conferred significant protection against a lethal dose of pandemic H1N1, PR8, H5N2, and highly pathogenic H5N1 viruses; this broad antiviral activity was dependent on macrophages but independent of neutrophils. fmOMV induced recruitment and activation of macrophages and elicited type I IFNs. Intriguingly, fmOMV showed a more significant protective effect than other TLR ligands tested in previous reports, without exhibiting any adverse effect. These results show the potential of fmOMV as a prophylactic agent for the defense against influenza virus infection. |
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| MeSH term(s) | Animals ; Bacterial Outer Membrane/immunology ; Escherichia coli/genetics ; Female ; Humans ; Influenza A virus/physiology ; Influenza Vaccines/immunology ; Influenza, Human/immunology ; Interferon Type I/metabolism ; Ligands ; Lipid A/genetics ; Lipid A/immunology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Orthomyxoviridae Infections/immunology ; Secretory Vesicles/immunology ; Signal Transduction ; Toll-Like Receptors/agonists |
| Chemical Substances | Influenza Vaccines ; Interferon Type I ; Ligands ; Lipid A ; Toll-Like Receptors |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2019-03-07 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2454158-8 |
| ISSN | 1662-8128 ; 1662-811X |
| ISSN (online) | 1662-8128 |
| ISSN | 1662-811X |
| DOI | 10.1159/000494098 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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