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  1. Book: Genomic imprinting

    Engel, Nora

    methods and protocols

    (Methods in molecular biology ; 925 ; Springer protocols)

    2012  

    Author's details ed. by Nora Engel
    Series title Methods in molecular biology ; 925
    Springer protocols
    Collection
    Keywords Genomic Imprinting
    Language English
    Size XI, 297 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017251657
    ISBN 978-1-62703-010-6 ; 1-62703-010-7 ; 9781627030113 ; 1627030115
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 420 available for loan (reading room) Lesesaal EG

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  2. Book: Genomic imprinting

    Wilkins, Jon F.

    (Advances in experimental medicine and biology ; 626)

    2008  

    Author's details ed. by Jon F. Wilkins
    Series title Advances in experimental medicine and biology ; 626
    Collection
    Keywords Genomic Imprinting
    Language English
    Size XVII, 125 S. : Ill., graph. Darst.
    Publisher Springer u.a.
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015474297
    ISBN 978-0-387-77575-3 ; 0-387-77575-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 3192 -626- not available for loan Zeitschriften-Lesesaal

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  3. Article: Genomic imprinting in human placentation.

    Kobayashi, Eri H / Shibata, Shun / Oike, Akira / Kobayashi, Norio / Hamada, Hirotaka / Okae, Hiroaki / Arima, Takahiro

    Reproductive medicine and biology

    2022  Volume 21, Issue 1, Page(s) e12490

    Abstract: Background: Genomic imprinting (GI) is a mammalian-specific epigenetic phenomenon that has been ... for self-renewal and differentiation of human TS cells.: Conclusion: Genomic imprinting plays diverse ...

    Abstract Background: Genomic imprinting (GI) is a mammalian-specific epigenetic phenomenon that has been implicated in the evolution of the placenta in mammals.
    Methods: Embryo transfer procedures and trophoblast stem (TS) cells were used to re-examine mouse placenta-specific GI genes. For the analysis of human GI genes, cytotrophoblast cells isolated from human placental tissues were used. Using human TS cells, the biological roles of human GI genes were examined.
    Main findings: (1) Many previously identified mouse GI genes were likely to be falsely identified due to contaminating maternal cells. (2) Human placenta-specific GI genes were comprehensively determined, highlighting incomplete erasure of germline DNA methylation in the human placenta. (3) Human TS cells retained normal GI patterns. (4) Complete hydatidiform mole-derived TS cells were characterized by aberrant GI and enhanced trophoblastic proliferation. The maternally expressed imprinted gene p57KIP2 may be responsible for the enhanced proliferation. (5) The primate-specific microRNA cluster on chromosome 19, which is a placenta-specific GI gene, is essential for self-renewal and differentiation of human TS cells.
    Conclusion: Genomic imprinting plays diverse and important roles in human placentation. Experimental analyses using TS cells suggest that the GI maintenance is necessary for normal placental development in humans.
    Language English
    Publishing date 2022-12-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2185775-1
    ISSN 1447-0578 ; 1445-5781
    ISSN (online) 1447-0578
    ISSN 1445-5781
    DOI 10.1002/rmb2.12490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6075: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Human Reproduction and Disturbed Genomic Imprinting.

    Eggermann, Thomas

    Genes

    2024  Volume 15, Issue 2

    Abstract: Genomic imprinting is a specific mode of gene regulation which particularly accounts ... with suspected altered genomic imprinting requires a specific workup to identify the precise molecular cause and ... the health of the mother. In children, aberrant imprinting signatures are associated with imprinting ...

    Abstract Genomic imprinting is a specific mode of gene regulation which particularly accounts for the factors involved in development. Its disturbance affects the fetus, the course of pregnancy and even the health of the mother. In children, aberrant imprinting signatures are associated with imprinting disorders (ImpDis). These alterations also affect the function of the placenta, which has consequences for the course of the pregnancy. The molecular causes of ImpDis comprise changes at the DNA level and methylation disturbances (imprinting defects/ImpDefs), and there is an increasing number of reports of both pathogenic fetal and maternal DNA variants causing ImpDefs. These ImpDefs can be inherited, but prediction of the pregnancy complications caused is difficult, as they can cause miscarriages, aneuploidies, health issues for the mother and ImpDis in the child. Due to the complexity of imprinting regulation, each pregnancy or patient with suspected altered genomic imprinting requires a specific workup to identify the precise molecular cause and also careful clinical documentation. This review will cover the current knowledge on the molecular causes of aberrant imprinting signatures and illustrate the need to identify this basis as the prerequisite for personalized genetic and reproductive counselling of families.
    MeSH term(s) Pregnancy ; Female ; Child ; Humans ; Genomic Imprinting ; Placenta ; Reproductive Techniques, Assisted ; Reproduction/genetics ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15020163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Detection of DNA methylation signatures through the lens of genomic imprinting.

    Hubert, Jean-Noël / Iannuccelli, Nathalie / Cabau, Cédric / Jacomet, Eva / Billon, Yvon / Serre, Rémy-Félix / Vandecasteele, Céline / Donnadieu, Cécile / Demars, Julie

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1694

    Abstract: ... multilocus imprinting variations across the genome, with implications for basic research, agrigenomics and ... Genomic imprinting represents an original model of epigenetic regulation resulting in a parent ... 165 candidate regions for genomic imprinting in the pig. This highlights the potential for a turnkey ...

    Abstract Genomic imprinting represents an original model of epigenetic regulation resulting in a parent-of-origin expression. Despite the critical role of imprinted genes in mammalian growth, metabolism and neuronal function, there is no molecular tool specifically targeting them for a systematic evaluation. We show here that enzymatic methyl-seq consistently outperforms the bisulfite-based standard in capturing 165 candidate regions for genomic imprinting in the pig. This highlights the potential for a turnkey, fully customizable and reliable capture tool of genomic regions regulated by cytosine methylation in any population of interest. For the field of genomic imprinting, it opens up the possibility of detecting multilocus imprinting variations across the genome, with implications for basic research, agrigenomics and clinical practice.
    MeSH term(s) Animals ; Swine ; Genomic Imprinting ; DNA Methylation ; Epigenesis, Genetic ; Gene Expression ; Genome ; Mammals/genetics
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52114-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Livestock species as emerging models for genomic imprinting.

    Hubert, Jean-Noël / Perret, Mathilde / Riquet, Juliette / Demars, Julie

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1348036

    Abstract: Genomic imprinting is an epigenetically-regulated process of central importance in mammalian ... of the genome. Genomic imprinting studies have therefore been essential to increase basic knowledge ... which features attractive resources in several respects, for better understanding genomic imprinting and ...

    Abstract Genomic imprinting is an epigenetically-regulated process of central importance in mammalian development and evolution. It involves multiple levels of regulation, with spatio-temporal heterogeneity, leading to the context-dependent and parent-of-origin specific expression of a small fraction of the genome. Genomic imprinting studies have therefore been essential to increase basic knowledge in functional genomics, evolution biology and developmental biology, as well as with regard to potential clinical and agrigenomic perspectives. Here we offer an overview on the contribution of livestock research, which features attractive resources in several respects, for better understanding genomic imprinting and its functional impacts. Given the related broad implications and complexity, we promote the use of such resources for studying genomic imprinting in a holistic and integrative view. We hope this mini-review will draw attention to the relevance of livestock genomic imprinting studies and stimulate research in this area.
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1348036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Genomic imprinting

    Ohlsson, Rolf

    an interdisciplinary approach

    (Results and problems in cell differentiation ; 25)

    1999  

    Author's details Rolf Ohlsson (ed.)
    Series title Results and problems in cell differentiation ; 25
    Collection
    Keywords Zelldifferenzierung ; Genetisches Imprinting
    Subject Genomische Prägung ; Genomisches Imprinting ; Zelle
    Language English
    Size XIII, 330 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT010299639
    ISBN 3-540-64667-1 ; 978-3-540-64667-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 2790 order for loan Magazin

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  8. Book: Genomic imprinting

    Reik, Wolf

    (Frontiers in molecular biology ; 18)

    1997  

    Author's details ed. by Wolf Reik
    Series title Frontiers in molecular biology ; 18
    Collection
    Keywords Genomic Imprinting ; Genetisches Imprinting
    Subject Genomische Prägung ; Genomisches Imprinting
    Language English
    Size XXI, 245 S. : Ill., graph. Darst.
    Publisher IRL Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT008395450
    ISBN 0-19-963625-7 ; 0-19-963626-5 ; 978-0-19-963625-9 ; 978-0-19-963626-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 3641 order for loan Magazin

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  9. Article ; Online: The phenomenon of genomic imprinting was discovered 40 years ago.

    Ferguson-Smith, Anne C / Bartolomei, Marisa S

    Nature

    2024  Volume 629, Issue 8013, Page(s) 763–765

    MeSH term(s) Genomic Imprinting/genetics ; Humans ; History, 20th Century ; Animals ; DNA Methylation/genetics ; Female ; Male ; History, 21st Century
    Language English
    Publishing date 2024-05-13
    Publishing country England
    Document type Historical Article ; Journal Article ; News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-024-01338-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  10. Article ; Online: Genomic Imprinting and Random Monoallelic Expression.

    Lobanova, Yaroslava V / Zhenilo, Svetlana V

    Biochemistry. Biokhimiia

    2023  Volume 89, Issue 1, Page(s) 84–96

    Abstract: The review discusses the mechanisms of monoallelic expression, such as genomic ... imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription ... on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects ...

    Abstract The review discusses the mechanisms of monoallelic expression, such as genomic imprinting, in which gene transcription depends on the parental origin of the allele, and random monoallelic transcription. Data on the regulation of gene activity in the imprinted regions are summarized with a particular focus on the areas controlling imprinting and factors influencing the variability of the imprintome. The prospects of studies of the monoallelic expression are discussed.
    MeSH term(s) Genomic Imprinting ; DNA Methylation ; Alleles
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1134/S000629792401005X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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