Article ; Online: Molecular toxicology of substances released from resin-based dental restorative materials.
International journal of molecular sciences
2009 Volume 10, Issue 9, Page(s) 3861–3899
Abstract: Resin-based dental restorative materials are extensively used today in dentistry ... effort has been focused on the determination of the molecular toxicology of substances released ... dose-response analysis. These studies have shown that substances released by these materials can cause ...
| Abstract | Resin-based dental restorative materials are extensively used today in dentistry. However, significant concerns still remain regarding their biocompatibility. For this reason, significant scientific effort has been focused on the determination of the molecular toxicology of substances released by these biomaterials, using several tools for risk assessment, including exposure assessment, hazard identification and dose-response analysis. These studies have shown that substances released by these materials can cause significant cytotoxic and genotoxic effects, leading to irreversible disturbance of basic cellular functions. The aim of this article is to review current knowledge related to dental composites' molecular toxicology and to give implications for possible improvements concerning their biocompatibility. |
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| MeSH term(s) | Animals ; Bacteria/drug effects ; DNA Damage ; Humans ; Methacrylates/pharmacokinetics ; Methacrylates/toxicity ; Mouth/drug effects ; Mouth/microbiology ; Polymerization ; Polymethacrylic Acids/pharmacokinetics ; Polymethacrylic Acids/toxicity ; Resins, Synthetic/pharmacokinetics ; Resins, Synthetic/toxicity |
| Chemical Substances | Methacrylates ; Polymethacrylic Acids ; Resins, Synthetic |
| Language | English |
| Publishing date | 2009-09-04 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms10093861 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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