Article ; Online: Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials.
2020
Abstract: Objective: To characterize hydroxychloroquine (HCQ) exposure in patients with rheumatic disease ... the coronavirus disease 2019 caused by SARS-CoV-2 (COVID-19).: Methods: We evaluated total HCQ concentrations ... for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or ...
| Abstract | Objective: To characterize hydroxychloroquine (HCQ) exposure in patients with rheumatic disease receiving longterm HCQ compared to target concentrations with reported antiviral activity against the coronavirus disease 2019 caused by SARS-CoV-2 (COVID-19). Methods: We evaluated total HCQ concentrations in serum and plasma from published literature values, frozen serum samples from a pediatric systemic lupus erythematosus trial, and simulated concentrations using a published pharmacokinetic model during pregnancy. For each source, we compared observed or predicted HCQ concentrations to target concentrations with reported antiviral activity against SARS-CoV-2. Results: The average total serum/plasma HCQ concentrations were below the lowest SARS-CoV-2 target of 0.48 mg/l in all studies. Assuming the highest antiviral target exposure (total plasma concentration of 4.1 mg/l), all studies had about one-tenth the necessary concentration for Conclusion: We found that the average patient receiving treatment with HCQ for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or plasma concentrations shown to inhibit SARS-CoV-2 |
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| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-11 |
| Publishing country | Canada |
| Document type | Journal Article |
| ZDB-ID | 194928-7 |
| ISSN | 1499-2752 ; 0315-162X |
| ISSN (online) | 1499-2752 |
| ISSN | 0315-162X |
| DOI | 10.3899/jrheum.200493 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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