Article ; Online: Spike protein mutational landscape in India during the complete lockdown phase: Could Muller's ratchet be a future game-changer for COVID-19?
2021 Volume 92, Page(s) 104874
Abstract: ... before the start of Unlock 1.0 in India on and from June 08, 2020), and detected the spike protein variants ... and its epidemiology in India, we studied the mutational diversity of spike glycoprotein, the key ... spike protein - host receptor (S-R) complexes for these variants correlated strongly (R ...
| Abstract | The dire need of effective preventive measures and treatment approaches against SARS-CoV-2 virus, causing COVID-19 pandemic, calls for an in-depth understanding of its evolutionary dynamics with attention to specific geographic locations, since lockdown and social distancing to prevent the virus spread could lead to distinct localized dynamics of virus evolution within and between countries owing to different environmental and host-specific selection pressures. To decipher any correlation between SARS-CoV-2 evolution and its epidemiology in India, we studied the mutational diversity of spike glycoprotein, the key player for the attachment, fusion and entry of virus to the host cell. For this, we analyzed the sequences of 630 Indian isolates as available in GISAID database till June 07, 2020 (during the time-period before the start of Unlock 1.0 in India on and from June 08, 2020), and detected the spike protein variants to emerge from two major ancestors - Wuhan-Hu-1/2019 and its D614G variant. Average stability of the docked spike protein - host receptor (S-R) complexes for these variants correlated strongly (R |
|---|---|
| Language | English |
| Publishing date | 2021-04-24 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 2037068-4 |
| ISSN | 1567-7257 ; 1567-1348 |
| ISSN (online) | 1567-7257 |
| ISSN | 1567-1348 |
| DOI | 10.1016/j.meegid.2021.104874 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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