Article ; Online: Seroprevalence of antibodies to SARS-CoV-2 among blood donors in the early months of the pandemic in Saudi Arabia.
2021 Volume 104, Page(s) 452–457
Abstract: ... of the COVID-19 pandemic in Saudi Arabia, the seroprevalence of antibodies to SARS-CoV-2 among blood donors was ... in Saudi Arabia.: Objective: To estimate the seroprevalence of anti-SARS-CoV-2 antibodies among blood donors ... data were analyzed for 837 adult blood donors, with no confirmed SARS-CoV-2 infection, in Saudi Arabia ...
Abstract | Background: Serologic testing provides better understanding of SARS-CoV-2 prevalence and its transmission. This study was an investigation of the prevalence of antibodies to SARS-CoV-2 among blood donors in Saudi Arabia. Objective: To estimate the seroprevalence of anti-SARS-CoV-2 antibodies among blood donors in Saudi Arabia during the early phase of the COVID-19 pandemic. Methods: Serology results and epidemiological data were analyzed for 837 adult blood donors, with no confirmed SARS-CoV-2 infection, in Saudi Arabia from 20th to 25th May 2020. Seroprevalence was determined using electrochemical immunoassay to detect anti-SARS-CoV-2 antibodies. Results: The overall seroprevalence of anti-SARS-CoV-2 antibodies was 1.4% (12/837). Non-citizens had higher seroprevalence compared with citizens (OR 13.6, p = 0.001). Secondary education was significantly associated with higher seroprevalence compared with higher education (OR 6.8, p = 0.005). The data showed that the highest seroprevalence was in Makkah (8.1%). Uisng Makkah seroprevalence as the reference, the seroprevalence in other areas was: Madinah 4.1% (OR 0.48, 95% CI 0.12-1.94), Jeddah 2.3% (OR 0.27, 95% CI 0.31-2.25), and Qassim 2.9 % (OR 0.34, 95% CI 0.04-2.89) and these were not statistically different from seroprevalence in the Makkah region. Conclusions: At the early months of the COVID-19 pandemic in Saudi Arabia, the seroprevalence of antibodies to SARS-CoV-2 among blood donors was low, but was higher among non-citizens. These findings may indicate that non-citizens and less educated individuals may be less attentive to preventive measures. Monitoring seroprevalence trends over time require repeated sampling. |
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MeSH term(s) | Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Blood Donors ; COVID-19/epidemiology ; COVID-19/immunology ; Cross-Sectional Studies ; Female ; Humans ; Immunoassay ; Immunoglobulin G/blood ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Saudi Arabia/epidemiology ; Seroepidemiologic Studies ; Young Adult | |||||
Chemical Substances | Antibodies, Viral ; Immunoglobulin G | |||||
Language | English | |||||
Publishing date | 2021-01-16 | |||||
Publishing country | Canada | |||||
Document type | Journal Article | |||||
ZDB-ID | 1331197-9 | |||||
ISSN | 1878-3511 ; 1201-9712 | |||||
ISSN (online) | 1878-3511 | |||||
ISSN | 1201-9712 | |||||
DOI | 10.1016/j.ijid.2021.01.028 | |||||
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Database | MEDical Literature Analysis and Retrieval System OnLINE |
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