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  1. Article ; Online: Coronavirus disease 2019 (COVID-19) and the risk of hypertensive disorders of pregnancy: a retrospective cohort study.

    Baracy, Michael / Afzal, Fareeza / Szpunar, Susanna M / Tremp, Makenzie / Grace, Karlee / Liovas, Marina / Aslam, Muhammad Faisal

    Hypertension in pregnancy

    2021  Volume 40, Issue 3, Page(s) 226–235

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Case-Control Studies ; Female ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Hypertension, Pregnancy-Induced/etiology ; Logistic Models ; Michigan/epidemiology ; Multivariate Analysis ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/epidemiology ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2021-08-24
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1151886-8
    ISSN 1525-6065 ; 1064-1955
    ISSN (online) 1525-6065
    ISSN 1064-1955
    DOI 10.1080/10641955.2021.1965621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coronavirus disease 2019 infection and hypertensive disorders of pregnancy.

    Rosenbloom, Joshua I / Raghuraman, Nandini / Carter, Ebony B / Kelly, Jeannie C

    American journal of obstetrics and gynecology

    2021  Volume 224, Issue 6, Page(s) 623–624

    MeSH term(s) COVID-19/complications ; Cohort Studies ; Female ; Gestational Age ; Humans ; Hypertension, Pregnancy-Induced/epidemiology ; Pregnancy ; Pregnancy Complications ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Letter
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2021.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Association Between Giving Birth During the Early Coronavirus Disease 2019 (COVID-19) Pandemic and Serious Maternal Morbidity.

    Metz, Torri D / Clifton, Rebecca G / Hughes, Brenna L / Sandoval, Grecio J / Grobman, William A / Saade, George R / Manuck, Tracy A / Longo, Monica / Sowles, Amber / Clark, Kelly / Simhan, Hyagriv N / Rouse, Dwight J / Mendez-Figueroa, Hector / Gyamfi-Bannerman, Cynthia / Bailit, Jennifer L / Costantine, Maged M / Sehdev, Harish M / Tita, Alan T N / Macones, George A

    Obstetrics and gynecology

    2022  Volume 141, Issue 1, Page(s) 109–118

    Abstract: Objective: To evaluate whether delivering during the early the coronavirus disease 2019 (COVID-19 ... morbidity from common obstetric complications, including hypertensive disorders of pregnancy (eclampsia, end ... cohort study with manual medical-record abstraction performed by centrally trained and certified ...

    Abstract Objective: To evaluate whether delivering during the early the coronavirus disease 2019 (COVID-19) pandemic was associated with increased risk of maternal death or serious morbidity from common obstetric complications compared with a historical control period.
    Methods: This was a multicenter retrospective cohort study with manual medical-record abstraction performed by centrally trained and certified research personnel at 17 U.S. hospitals. Individuals who gave birth on randomly selected dates in 2019 (before the pandemic) and 2020 (during the pandemic) were compared. Hospital, health care system, and community risk-mitigation strategies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in response to the early COVID-19 pandemic are described. The primary outcome was a composite of maternal death or serious morbidity from common obstetric complications, including hypertensive disorders of pregnancy (eclampsia, end organ dysfunction, or need for acute antihypertensive therapy), postpartum hemorrhage (operative intervention or receipt of 4 or more units blood products), and infections other than SARS-CoV-2 (sepsis, pelvic abscess, prolonged intravenous antibiotics, bacteremia, deep surgical site infection). The major secondary outcome was cesarean birth.
    Results: Overall, 12,133 patients giving birth during and 9,709 before the pandemic were included. Hospital, health care system, and community SARS-CoV-2 mitigation strategies were employed at all sites for a portion of 2020, with a peak in modifications from March to June 2020. Of patients delivering during the pandemic, 3% had a positive SARS-CoV-2 test result during pregnancy through 42 days postpartum. Giving birth during the pandemic was not associated with a change in the frequency of the primary composite outcome (9.3% vs 8.9%, adjusted relative risk [aRR] 1.02, 95% CI 0.93-1.11) or cesarean birth (32.4% vs 31.3%, aRR 1.02, 95% CI 0.97-1.07). No maternal deaths were observed.
    Conclusion: Despite substantial hospital, health care, and community modifications, giving birth during the early COVID-19 pandemic was not associated with higher rates of serious maternal morbidity from common obstetric complications.
    Clinical trial registration: ClinicalTrials.gov, NCT04519502.
    MeSH term(s) Female ; Humans ; Pregnancy ; Cesarean Section ; COVID-19/epidemiology ; Parturition ; Retrospective Studies ; Maternal Death/statistics & numerical data ; Delivery, Obstetric/adverse effects ; Delivery, Obstetric/statistics & numerical data ; Time Factors ; Morbidity ; Risk Assessment
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Clinical Study ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000004982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy Outcomes in a U.S. Population.

    Son, Moeun / Gallagher, Kieran / Lo, Justin Y / Lindgren, Eric / Burris, Heather H / Dysart, Kevin / Greenspan, Jay / Culhane, Jennifer F / Handley, Sara C

    Obstetrics and gynecology

    2021  Volume 138, Issue 4, Page(s) 542–551

    Abstract: Objective: To examine whether the coronavirus disease 2019 (COVID-19) pandemic altered risk ... of adverse pregnancy-related outcomes and whether there were differences by severe acute respiratory syndrome ... coronavirus 2 (SARS-CoV-2) infection status among pregnant women.: Methods: In this retrospective ...

    Abstract Objective: To examine whether the coronavirus disease 2019 (COVID-19) pandemic altered risk of adverse pregnancy-related outcomes and whether there were differences by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection status among pregnant women.
    Methods: In this retrospective cohort study using Epic's Cosmos research platform, women who delivered during the pandemic (March-December 2020) were compared with those who delivered prepandemic (matched months 2017-2019). Within the pandemic epoch, those who tested positive for SARS-CoV-2 infection were compared with those with negative test results or no SARS-CoV-2 diagnosis. Comparisons were performed using standardized differences, with a value greater than 0.1 indicating meaningful differences between groups.
    Results: Among 838,489 women (225,225 who delivered during the pandemic), baseline characteristics were similar between epochs. There were no significant differences in adverse pregnancy outcomes between epochs (standardized difference<0.10). In the pandemic epoch, 108,067 (48.0%) women had SARS-CoV-2 testing available; of those, 7,432 (6.9%) had positive test results. Compared with women classified as negative for SARS-CoV-2 infection, those who tested positive for SARS-CoV-2 infection were less likely to be non-Hispanic White or Asian or to reside in the Midwest and more likely to be Hispanic, have public insurance, be obese, and reside in the South or in high social vulnerability ZIP codes. There were no significant differences in the frequency of preterm birth (8.5% vs 7.6%, standardized difference=0.032), stillbirth (0.4% vs 0.4%, standardized difference=-0.002), small for gestational age (6.4% vs 6.5%, standardized difference=-0.002), large for gestational age (7.7% vs 7.7%, standardized difference=-0.001), hypertensive disorders of pregnancy (16.3% vs 15.8%, standardized difference=0.014), placental abruption (0.5% vs 0.4%, standardized difference=0.007), cesarean birth (31.2% vs 29.4%, standardized difference=0.039), or postpartum hemorrhage (3.4% vs 3.1%, standardized difference=0.019) between those who tested positive for SARS-CoV-2 infection and those classified as testing negative.
    Conclusion: In a geographically diverse U.S. cohort, the frequency of adverse pregnancy-related outcomes did not differ between those delivering before compared with during the pandemic, nor between those classified as positive compared with negative for SARS-CoV-2 infection during pregnancy.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19 Testing/statistics & numerical data ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/virology ; Pregnancy Outcome/epidemiology ; Prenatal Care/statistics & numerical data ; Retrospective Studies ; SARS-CoV-2 ; United States/epidemiology
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000004547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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