Article ; Online: COVID-19 Autopsies, Oklahoma, USA.
American journal of clinical pathology
2020 Volume 153, Issue 6, Page(s) 725–733
Abstract: ... protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time ... Objectives: To report the methods and findings of two complete autopsies ... of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals who died in Oklahoma (United States) in March 2020 ...
| Abstract | Objectives: To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals who died in Oklahoma (United States) in March 2020. Methods: Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs. Results: A 77-year-old obese man with a history of hypertension, splenectomy, and 6 days of fever and chills died while being transported for medical care. He tested positive for SARS-CoV-2 on postmortem nasopharyngeal and lung parenchymal swabs. Autopsy revealed diffuse alveolar damage and chronic inflammation and edema in the bronchial mucosa. A 42-year-old obese man with a history of myotonic dystrophy developed abdominal pain followed by fever, shortness of breath, and cough. Postmortem nasopharyngeal swab was positive for SARS-CoV-2; lung parenchymal swabs were negative. Autopsy showed acute bronchopneumonia with evidence of aspiration. Neither autopsy revealed viral inclusions, mucus plugging in airways, eosinophils, or myocarditis. Conclusions: SARS-CoV-2 testing can be performed at autopsy. Autopsy findings such as diffuse alveolar damage and airway inflammation reflect true virus-related pathology; other findings represent superimposed or unrelated processes. |
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| MeSH term(s) | Adult ; Aged ; Autopsy/instrumentation ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Clinical Laboratory Techniques/standards ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/pathology ; Diagnosis ; Humans ; Hypertension/complications ; Lung/pathology ; Male ; Myotonic Dystrophy/complications ; Obesity/complications ; Oklahoma ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/pathology ; SARS-CoV-2 |
| Chemical Substances | COVID-19 Vaccines ; Covid-19 aAPC vaccine |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-09 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 2944-0 |
| ISSN | 1943-7722 ; 0002-9173 |
| ISSN (online) | 1943-7722 |
| ISSN | 0002-9173 |
| DOI | 10.1093/ajcp/aqaa062 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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