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  1. Article: Impact of coronavirus disease 2019 on semen parameters.

    Basourakos, Spyridon P / Schlegel, Peter N

    Asian journal of urology

    2021  Volume 9, Issue 2, Page(s) 190–192

    Language English
    Publishing date 2021-06-24
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2831144-9
    ISSN 2214-3882
    ISSN 2214-3882
    DOI 10.1016/j.ajur.2021.06.004
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  2. Article: The impact of the COVID-19 pandemic on semen quality of uninfected men.

    Zhang, Wenjun / Wang, Li / Sun, Jiwei / Cui, Linlin / Zhang, Haobo / Hu, Jingmei

    Basic and clinical andrology

    2023  Volume 33, Issue 1, Page(s) 4

    Abstract: Background: Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide since its discovery ... quality of uninfected men. This study aimed to compare semen parameters among uninfected Chinese sperm donors before and ... lifestyle changes on uninfected men.: Results: All semen parameters were non-significant except semen ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide since its discovery in December 2019. Research published since the COVID-19 outbreak has focused on whether semen quality and reproductive hormone levels are affected by COVID-19. However, there is limited evidence on semen quality of uninfected men. This study aimed to compare semen parameters among uninfected Chinese sperm donors before and after the COVID-19 pandemic to determine the impact of the COVID-19 pandemic-related stress and lifestyle changes on uninfected men.
    Results: All semen parameters were non-significant except semen volume. The average age of sperm donors was higher after the COVID-19 (all P < 0.05). The average age of qualified sperm donors increased from 25.9 (SD: 5.3) to 27.6 (SD: 6.0) years. Before the COVID-19, 45.0% qualified sperm donors were students, but after the COVID-19, 52.9% were physical laborers (P < 0.05). The proportion of qualified sperm donors with a college education dropped from 80.8 to 64.4% after the COVID-19 (P < 0.05).
    Conclusion: Although the sociodemographic characteristics of sperm donors changed after the COVID-19 pandemic, no decline in semen quality was found. There is no concern about the quality of cryopreserved semen in human sperm banks after the COVID-19 pandemic.
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2732675-5
    ISSN 2051-4190
    ISSN 2051-4190
    DOI 10.1186/s12610-022-00180-w
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  3. Article ; Online: Impact of COVID-19 on sperm quality and the prostaglandin and polyamine systems in the seminal fluid.

    Matzkin, María Eugenia / Beguerie, Celina / De Zuñiga, Ignacio / Martinez, Gustavo / Frungieri, Mónica Beatriz

    Andrology

    2023  

    Abstract: ... diminished in semen obtained up to 6 months after coronavirus disease 2019 recovery, these parameters ... by thin-layer chromatography were assessed.: Results: In both groups of semen samples from coronavirus disease 2019 ... Coronavirus disease 2019 vaccination did not show negative effects on any of the parameters evaluated ...

    Abstract Background: The implications of SARS-CoV-2 infection on male fertility remain largely unknown. Besides their well-known pro- and anti-inflammatory actions, prostaglandins and polyamines are present in semen, where they play key roles in sperm quality.
    Objectives: To analyze semen parameters, oxidative profile and the seminal fluid prostaglandin and polyamine systems in samples collected from individuals without coronavirus disease 2019 diagnosis and men who recovered from coronavirus disease 2019.
    Materials and methods: This study compared semen collected from men without positive coronavirus disease 2019 diagnosis with samples obtained from individuals 1-6 months and 7-30 months post SARS-CoV-2 infection. Semen parameters, thiobarbituric acid reactive substances, cyclooxygenase 2 expression by fluorescence immunocytochemistry and immunoblotting, prostaglandin levels by enzyme immunoassay, ornithine decarboxylase activity by a radioactive assay, and polyamine and acetylated polyamine levels by thin-layer chromatography were assessed.
    Results: In both groups of semen samples from coronavirus disease 2019 recovered men, sperm vitality, total and progressive sperm motility, and putrescine levels were significantly decreased when compared with samples from the uninfected group. In contrast, lipid peroxidation, leukocyte-associated cyclooxygenase 2 expression, and prostaglandin D2 levels were higher in semen from coronavirus disease 2019 recovered men than in samples from uninfected individuals. While sperm concentration and morphology, ornithine decarboxylase activity, and N-acetylputrescine levels were statistically diminished in semen obtained up to 6 months after coronavirus disease 2019 recovery, these parameters remained unchanged when samples were collected 7-30 months after coronavirus disease 2019 recovery. Coronavirus disease 2019 vaccination did not show negative effects on any of the parameters evaluated.
    Discussion and conclusion: Our work provides insights into the detrimental impact of coronavirus disease 2019 on several sperm parameters, in some cases, even more than a year after SARS-CoV-2 infection, which would be accompanied by alterations in the seminal fluid prostaglandin and polyamine profiles. Therefore, future treatments targeting the prostaglandin and polyamine pathways in coronavirus disease 2019 recovered men could lead to a successful reinstatement of semen parameters.
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13548
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  4. Article: Impact of COVID-19 convalescence on pregnancy outcomes in patients undergoing IVF/ICSI during fresh ART cycles: a retrospective cohort study.

    Cao, Mingya / Han, Yan / Feng, Tengfei / Lu, Peiyang / Wang, Yue / Sun, Qingyun / Zhao, Zhiming / Pan, Wensen

    Frontiers in endocrinology

    2024  Volume 14, Page(s) 1298995

    Abstract: Objective: The aim was to study the impact of coronavirus disease 2019 (COVID-19) convalescence ... demographic characteristics and laboratory parameters of patients in each group. The primary outcome measure ... was the clinical pregnancy rate, which was examined to assess the impact of COVID-19 infection ...

    Abstract Objective: The aim was to study the impact of coronavirus disease 2019 (COVID-19) convalescence on female fertility and laboratory and clinical outcomes in fresh assisted reproductive technology (ART) cycles.
    Methods: In this retrospective cohort study, we analyzed data from 294 patients who had recovered from COVID-19 and who underwent fresh ART cycles between January and March 2023 (COVID-19 group). This group was compared with 631 patients who underwent similar ART cycles in the same period in 2022 but without having been infected with COVID-19 (non-COVID-19 group). The analysis focused on comparison of basic demographic characteristics and laboratory parameters of patients in each group. The primary outcome measure was the clinical pregnancy rate, which was examined to assess the impact of COVID-19 infection on the efficacy of ART treatment.
    Results: Basal follicle-stimulating hormone (FSH) levels were significantly lower and antral follicle count (AFC) was markedly higher in the COVID-19 group compared to the non-COVID-19 group (P<0.001 and P=0.004, respectively). The predominant ovarian stimulation protocol in the COVID-19 group was GnRH antagonists (64.85%, P<0.001), with a reduced gonadotropin (Gn) dosage and duration in comparison to the non-COVID-19 group (P<0.05). Although the number of blastocysts formed was lower in the COVID-19 group (P=0.017), this group also exhibited a higher blastocyst freezing rate and a higher rate of high-quality embryos per retrieved oocyte (P<0.001 and P=0.023, respectively). Binary logistic regression analysis indicated that COVID-19 convalescence did not significantly impact clinical pregnancy rates in fresh transfer cycles (odds ratio [OR] = 1.16, 95% confidence interval [CI] = 0.68-1.96, P=0.5874). However, smooth curve-fitting and threshold effect analysis revealed an age-related decline in clinical pregnancy rates in both groups, more pronounced in the COVID-19 group, for women aged over 38 years, with the likelihood of clinical pregnancy decreasing by 53% with each additional year of age (odds ratio [OR] = 0.81, 95% confidence interval [CI] = 0.61-1.08, P=0.1460; odds ratio [OR] = 0.47, 95% CI = 0.21-1.05, P=0.0647).
    Conclusions: Our findings present no substantial evidence of adverse effects on clinical pregnancy outcomes in fresh ART cycles in patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) during the period of convalescence from COVID-19. However, age emerges as a significant factor influencing these outcomes. Notably, for women above 38 years of age, the likelihood of clinical pregnancy in patients with a prior COVID-19 infection decreased by 53% with each additional year. This highlights the importance of considering maternal age, especially in the context of COVID-19, when evaluating the likelihood of successful pregnancy following ART treatments.
    MeSH term(s) Male ; Pregnancy ; Humans ; Female ; Pregnancy Outcome/epidemiology ; Sperm Injections, Intracytoplasmic/methods ; Retrospective Studies ; Convalescence ; Live Birth ; COVID-19/therapy ; Semen ; Reproductive Techniques, Assisted ; Fertilization in Vitro/methods
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1298995
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  5. Article: The impact of COVID-19 on the male reproductive tract and fertility: A systematic review.

    Sengupta, Pallav / Leisegang, Kristian / Agarwal, Ashok

    Arab journal of urology

    2021  Volume 19, Issue 3, Page(s) 423–436

    Abstract: ... to provide a concise update on the effects of coronavirus disease 2019 (COVID-19) on male reproduction ... Conclusions: Clinical evaluation of the male reproductive tract, seminal parameters and reproductive hormones ... coronavirus (SARS-CoV-2) causing coronavirus disease (COVID-19), that inflicts more males than females ...

    Abstract Objective: The COVID-19 pandemic, caused by the acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), remains an ongoing public health challenge. Although males are affected slightly more than females, the impact of SARS-COV-2 on male reproductive system remains unclear. This systematic review aims to provide a concise update on the effects of COVID-19 on male reproductive health, including the presence of viral RNA in semen, and the impact on semen quality, testicular histology, testicular pain and male reproductive hormones. The global health is fronting an immediate as well as impending threat from the novel coronavirus (SARS-CoV-2) causing coronavirus disease (COVID-19), that inflicts more males than females. Evidence suggest that male reproductive system is susceptible to this viral infection. However, there are still several pertinent queries that remain to be fully explained regarding the mechanism in testicular SARS-CoV-2 dynamics and the exact mode of its actions. Thus, the present systematic review aims to provide a concise update on the effects of coronavirus disease 2019 (COVID-19) on male reproduction..
    Methods: A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines searching the PubMed database. Eligibility for inclusion were original human studies evaluating the impact of COVID-19 on male reproductive health. Specific outcomes required for inclusion were at least one of the following: i) seminal detection of mRNA virus, or evaluation of ii) semen analysis, iii) testicular histology or ultrasonography, iv) testicular clinical symptoms and/or v) male reproductive hormones in COVID-19-positive patients.
    Results: Of 553 retrieved articles, 25 met the inclusion criteria. This included studies primarily investigating the presence of viral RNA in semen (
    Conclusions: Clinical evaluation of the male reproductive tract, seminal parameters and reproductive hormones is recommended in patients with current or a history of COVID-19, particularly in males undergoing fertility treatment. Any long-term negative impact on male reproduction remains unexplored and an important future consideration.
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2631788-6
    ISSN 2090-598X
    ISSN 2090-598X
    DOI 10.1080/2090598X.2021.1955554
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  6. Article ; Online: The impact of acute SARS-CoV-2 on testicular function including insulin-like factor 3 (INSL3) in men with mild COVID-19: A longitudinal study.

    Lauritsen, Mette Petri / Kristensen, Thomas Leineweber / Hansen, Christine Bo / Schneider, Uffe Vest / Talbot, Anna Lando / Skytte, Anne-Bine / Petersen, Jørgen Holm / Johannsen, Trine Holm / Zedeler, Anne / Albrethsen, Jakob / Juul, Anders / Priskorn, Laerke / Jørgensen, Niels / Westh, Henrik / Freiesleben, Nina la Cour / Nielsen, Henriette Svarre

    Andrology

    2023  Volume 12, Issue 2, Page(s) 437–446

    Abstract: ... Reproductive hormone levels, semen parameters, and the presence of SARS-CoV-2 RNA in oropharyngeal and semen ... in reproductive hormone levels and semen parameters.: Results: Lower plasma testosterone (T) (total and ... as an entry point into the cell. Few studies have evaluated the long-term effects of mild coronavirus disease ...

    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the male reproductive system as it uses angiotensin-converting enzyme (ACE)2, which is expressed in testicular tissue, as an entry point into the cell. Few studies have evaluated the long-term effects of mild coronavirus disease 2019 (COVID-19) on testicular function, and insulin-like factor 3 (INSL3) levels have not previously been assessed during acute SARS-CoV-2 infection.
    Objectives: The aim of the study was to assess the impact of acute SARS-CoV-2 infection on testicular function including INSL3 and the presence of SARS-CoV-2 RNA in semen in non-hospitalised men with mild COVID-19.
    Materials and methods: This longitudinal study included 36 non-hospitalised SARS-CoV-2-positive men (median age 29 years). Inclusion was within seven days following a positive SARS-CoV-2 reverse-transcription polymerase chain reaction test. Reproductive hormone levels, semen parameters, and the presence of SARS-CoV-2 RNA in oropharyngeal and semen samples were assessed during acute SARS-CoV-2 infection (baseline) and at three- and six-month follow-up. Wilcoxon matched-pair signed-rank (two samples) test was used to assess time-related alterations in reproductive hormone levels and semen parameters.
    Results: Lower plasma testosterone (T) (total and calculated free (c-fT)) and higher luteinising hormone (LH) concentrations were observed during acute SARS-CoV-2 infection (baseline) compared to three- and six-month follow-up. Consequently, ratios of c-fT/LH were lower at baseline compared to three- and six-month follow-up (p < 0.001 and p = 0.003, respectively). Concomitantly, lower INSL3 concentrations were observed at baseline compared to three-month follow-up (p = 0.01). The total number of motile spermatozoa was also lower at baseline compared to six-month follow-up (p = 0.02). The alterations were detected irrespective of whether the men had experienced SARS-CoV-2-related fever episodes or not. No SARS-CoV-2 RNA was detected in semen at any time point.
    Discussion and conclusion: This study showed a reduction in testicular function, which was for the first time confirmed by INSL3, in men mildly affected by SARS-CoV-2 infection. The risk of transmission of SARS-CoV-2 RNA via semen seems to be low. Febrile episodes may impact testicular function, but a direct effect of SARS-CoV-2 cannot be excluded.
    MeSH term(s) Adult ; Humans ; Male ; COVID-19 ; Insulins ; Longitudinal Studies ; Luteinizing Hormone ; RNA, Viral ; SARS-CoV-2 ; Semen ; Testosterone
    Chemical Substances Insulins ; Luteinizing Hormone (9002-67-9) ; RNA, Viral ; Testosterone (3XMK78S47O) ; Leydig insulin-like protein
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13494
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6983: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Evaluation of mid- and long-term impact of COVID-19 on male fertility through evaluating semen parameters.

    Hu, Bintao / Liu, Kang / Ruan, Yajun / Wei, Xian / Wu, Yue / Feng, Huan / Deng, Zhiyao / Liu, Jihong / Wang, Tao

    Translational andrology and urology

    2021  Volume 11, Issue 2, Page(s) 159–167

    Abstract: Background: The coronavirus disease 2019 (COVID-19) has spread worldwide with alarming levels ... difference in semen parameters between male recovered patients and control subjects. And the comparisons ... of semen parameters between first follow-up and second follow-up revealed no significant difference ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) has spread worldwide with alarming levels of spread and severity. The distribution of angiotensin converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) from bioinformatics evidence, the autopsy report for COVID-19 and the published study on sperm quality indicated COVID-19 could have a negative impact on male fertility. However, whether the negative impact of COVID-19 on male fertility is persistent remains unknown, which requires long-term follow-up investigation.
    Methods: Semen samples were collected from 36 male COVID-19 patients with a median recovery time of 177.5 days and 45 control subjects. Then, analysis of sperm quality and alterations of total sperm number with recovery time were performed.
    Results: There was no significant difference in semen parameters between male recovered patients and control subjects. And the comparisons of semen parameters between first follow-up and second follow-up revealed no significant difference. In addition, we explored the alterations of sperm count with recovery time. It showed that the group with recovery time of ≥120 and <150 days had a significantly lower total sperm number than controls while the other two groups with recovery time of ≥150 days displayed no significance with controls, and total sperm number showed a significant decline after a recovery time of 90 days and an improving trend after a recovery time of about 150 days.
    Conclusions: The sperm quality of COVID-19 recovered patients improved after a recovery time of nearly half a year, while the total sperm number showed an improvement after a recovery time of about 150 days. COVID-19 patients should pay close attention to the quality of semen, and might be considered to be given medical interventions if necessary within about two months after recovery, in order to improve the fertility of male patients as soon as possible.
    Language English
    Publishing date 2021-12-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-21-922
    Database MEDical Literature Analysis and Retrieval System OnLINE

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