Article: Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10.
1994 Volume 68, Issue 11, Page(s) 7575–7581
Abstract: ... 5) and IL-10 with virus dose-dependent high levels of gamma interferon. However, cytokine production ... a virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses mRNA for interleukin-5 (IL ... in lung tissues was not restricted to the T-cell population, since CD3- cells were found to express mRNA ...
| Abstract | Analysis of the respiratory tract before and after primary influenza virus infection revealed a virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses mRNA for interleukin-5 (IL-5) and IL-10 with virus dose-dependent high levels of gamma interferon. However, cytokine production in lung tissues was not restricted to the T-cell population, since CD3- cells were found to express mRNA for various cytokines, including IL-4 and particularly IL-6 and granulocyte-macrophage colony-stimulating factor. These data provide in vivo evidence for a local respiratory tract immune response to influenza virus infection dominated by cytokine-producing CD8+ T cells. |
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| MeSH term(s) | Animals ; Base Sequence ; CD3 Complex/analysis ; Cytokines/biosynthesis ; Cytokines/genetics ; Female ; Interferon-gamma/biosynthesis ; Interferon-gamma/genetics ; Interleukin-10/biosynthesis ; Interleukin-10/genetics ; Interleukin-5/biosynthesis ; Interleukin-5/genetics ; Lung/immunology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/metabolism ; RNA, Messenger/analysis ; T-Lymphocytes/immunology | |||||
| Chemical Substances | CD3 Complex ; Cytokines ; Interleukin-5 ; RNA, Messenger ; Interleukin-10 (130068-27-8) ; Interferon-gamma (82115-62-6) | |||||
| Language | English | |||||
| Publishing date | 1994-11 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80174-4 | |||||
| ISSN | 1098-5514 ; 0022-538X | |||||
| ISSN (online) | 1098-5514 | |||||
| ISSN | 0022-538X | |||||
| DOI | 10.1128/JVI.68.11.7575-7581.1994 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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