Article: Possible roles of LI-Cadherin in the formation and maintenance of the intestinal epithelial barrier.
Tissue barriers
2014 Volume 1, Issue 1, Page(s) e23815
Abstract: ... physiological conditions LI-cadherin is expressed in the intestine and colon in human and mouse and in the rat ... Although there are several hypothesis and theoretical models concerning the function of LI-cadherin ... the physiological role of LI-cadherin is still enigmatic. ...
| Abstract | LI-cadherin belongs to the so called 7D-cadherins, exceptional members of the cadherin superfamily which are characterized by seven extracellular cadherin repeats and a small cytosolic domain. Under physiological conditions LI-cadherin is expressed in the intestine and colon in human and mouse and in the rat also in hepatocytes. LI-cadherin was shown to act as a functional Ca(2+)-dependent adhesion molecule, linking neighboring cells and a lot of biophysical and biochemical parameters were determined in the last time. It is also known that dysregulated LI-cadherin expression can be found in a variety of diseases. Although there are several hypothesis and theoretical models concerning the function of LI-cadherin, the physiological role of LI-cadherin is still enigmatic. |
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| Language | English |
| Publishing date | 2014-02-09 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2168-8362 |
| ISSN | 2168-8362 |
| DOI | 10.4161/tisb.23815 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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