Article ; Online: Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
2021 Volume 34, Issue 7, Page(s) 1345–1357
Abstract: ... the relationships between cardiac pathological changes in patients dying from COVID-19 and cardiac infection by SARS ... inflammation, myocarditis, cardiac infection by SARS-CoV-2, clinical features, laboratory measurements, and ... COVID-19 has been associated with cardiac injury and dysfunction. While both myocardial ...
| Abstract | COVID-19 has been associated with cardiac injury and dysfunction. While both myocardial inflammatory cell infiltration and myocarditis with myocyte injury have been reported in patients with fatal COVID-19, clinical-pathologic correlations remain limited. The objective was to determine the relationships between cardiac pathological changes in patients dying from COVID-19 and cardiac infection by SARS-CoV-2, laboratory measurements, clinical features, and treatments. In a retrospective study, 41 consecutive autopsies of patients with fatal COVID-19 were analyzed for the associations between cardiac inflammation, myocarditis, cardiac infection by SARS-CoV-2, clinical features, laboratory measurements, and treatments. Cardiac infection was assessed by in situ hybridization and NanoString transcriptomic profiling. Cardiac infection by SARS-CoV-2 was present in 30/41 cases: virus |
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| MeSH term(s) | Aged ; Anticoagulants/therapeutic use ; Autopsy ; COVID-19/blood ; COVID-19/pathology ; Echocardiography ; Electrocardiography ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Myocarditis/pathology ; Myocarditis/virology ; Myocardium/pathology ; Retrospective Studies ; SARS-CoV-2/physiology ; COVID-19 Drug Treatment | |||||
| Chemical Substances | Anticoagulants ; Immunosuppressive Agents | |||||
| Language | English | |||||
| Publishing date | 2021-03-17 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 645073-8 | |||||
| ISSN | 1530-0285 ; 0893-3952 | |||||
| ISSN (online) | 1530-0285 | |||||
| ISSN | 0893-3952 | |||||
| DOI | 10.1038/s41379-021-00790-1 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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