Article ; Online: Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.
2018 Volume 8, Issue 1, Page(s) 3023
Abstract: ... that involves obligatory cytosolic calcium elevations. Store-operated calcium entry (SOCE) pathway is ... T lymphocytes enlarge (blast) and proliferate in response to antigens in a multistep program ...
| Abstract | T lymphocytes enlarge (blast) and proliferate in response to antigens in a multistep program that involves obligatory cytosolic calcium elevations. Store-operated calcium entry (SOCE) pathway is the primary source of Ca |
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| MeSH term(s) | Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling/physiology ; Cell Proliferation/physiology ; Gene Knock-In Techniques/methods ; Lymphocyte Activation/physiology ; Magnesium/metabolism ; Mice ; Mice, Inbred C57BL ; Spleen/pathology ; Splenomegaly/metabolism ; Stromal Interaction Molecule 1/metabolism ; T-Lymphocytes/metabolism ; T-Lymphocytes/physiology ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism |
| Chemical Substances | Calcium Channels ; Stromal Interaction Molecule 1 ; TRPM Cation Channels ; Trpm7 protein, mouse (EC 2.7.1.-) ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP) |
| Language | English |
| Publishing date | 2018-02-14 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-018-21004-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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