Article ; Online: Atherogenic Dyslipidemia on Admission Is Associated With Poorer Outcome in People With and Without Diabetes Hospitalized for COVID-19.
2021 Volume 44, Issue 9, Page(s) 2149–2157
Abstract: ... We examined associations of atherogenic dyslipidemia detected on admission with outcome of COVID-19 during ... levels characterize the atherogenic dyslipidemia closely related to insulin resistance and diabetes ... logistic regression analysis.: Results: Patients with critical COVID-19 (: Conclusions: Atherogenic dyslipidemia ...
| Abstract | Objective: Identifying metabolic factors associated with critical disease can help to improve management of patients hospitalized for coronavirus disease 2019 (COVID-19). High triglycerides and low HDL levels characterize the atherogenic dyslipidemia closely related to insulin resistance and diabetes. We examined associations of atherogenic dyslipidemia detected on admission with outcome of COVID-19 during hospitalization. Research design and methods: We retrospectively analyzed clinical reports of 118 consecutive patients hospitalized for COVID-19 in Rome, Italy, between March and May 2020. Clinical characteristics, inflammation markers, and glucose and lipid metabolism parameters at admission were collected. Critical disease was defined as in-hospital death or need for endotracheal intubation. Associations were tested using logistic regression analysis. Results: Patients with critical COVID-19 ( Conclusions: Atherogenic dyslipidemia detected on admission can be associated with critical in-hospital course of COVID-19. Further investigations are needed to elucidate the hypothetical role of insulin resistance and related lipid abnormalities in severe acute respiratory syndrome coronavirus 2 pathogenesis. Assessment of lipid profile should be encouraged in patients hospitalized for COVID-19. |
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| MeSH term(s) | COVID-19 ; Diabetes Mellitus ; Dyslipidemias/complications ; Dyslipidemias/epidemiology ; Hospital Mortality ; Hospitalization ; Humans ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-07-12 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 441231-x | ||||||||||
| ISSN | 1935-5548 ; 0149-5992 | ||||||||||
| ISSN (online) | 1935-5548 | ||||||||||
| ISSN | 0149-5992 | ||||||||||
| DOI | 10.2337/dc20-2838 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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