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  1. Article ; Online: Assessment of SARS-CoV-2 replication in the context of other respiratory viruses.

    Belser, Jessica A

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 7, Page(s) 651–652

    MeSH term(s) Betacoronavirus ; COVID-19 ; Conjunctiva ; Coronavirus Infections ; Humans ; Immunity, Innate ; Pandemics ; Pneumonia, Viral ; Respiratory System ; SARS Virus ; SARS-CoV-2 ; Tropism
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30227-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Assessment of SARS-CoV-2 replication in the context of other respiratory viruses

    Belser, Jessica A

    The Lancet Respiratory Medicine

    2020  Volume 8, Issue 7, Page(s) 651–652

    Keywords Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/s2213-2600(20)30227-7
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: A COVID moonshot: assessment of ligand binding to the SARS-CoV-2 main protease by saturation transfer difference NMR spectroscopy

    Kantsadi, Anastassia L. / Cattermole, Emma / Matsoukas, Minos-Timotheos / Spyroulias, Georgios A. / Vakonakis, Ioannis

    Journal of biomolecular NMR. 2021 May, v. 75, no. 4-5

    2021  

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological cause ... of the coronavirus disease 2019, for which no effective antiviral therapeutics are available. The SARS-CoV-2 main ... and challenges faced, thereby placing these data into context. Our goal is to assist ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological cause of the coronavirus disease 2019, for which no effective antiviral therapeutics are available. The SARS-CoV-2 main protease (Mᵖʳᵒ) is essential for viral replication and constitutes a promising therapeutic target. Many efforts aimed at deriving effective Mᵖʳᵒ inhibitors are currently underway, including an international open-science discovery project, codenamed COVID Moonshot. As part of COVID Moonshot, we used saturation transfer difference nuclear magnetic resonance (STD-NMR) spectroscopy to assess the binding of putative Mᵖʳᵒ ligands to the viral protease, including molecules identified by crystallographic fragment screening and novel compounds designed as Mᵖʳᵒ inhibitors. In this manner, we aimed to complement enzymatic activity assays of Mᵖʳᵒ performed by other groups with information on ligand affinity. We have made the Mᵖʳᵒ STD-NMR data publicly available. Here, we provide detailed information on the NMR protocols used and challenges faced, thereby placing these data into context. Our goal is to assist the interpretation of Mᵖʳᵒ STD-NMR data, thereby accelerating ongoing drug design efforts.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; drug design ; enzyme activity ; etiology ; ligands ; nuclear magnetic resonance spectroscopy ; proteinases ; therapeutics ; virus replication
    Language English
    Dates of publication 2021-05
    Size p. 167-178.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1081696-3
    ISSN 0925-2738
    ISSN 0925-2738
    DOI 10.1007/s10858-021-00365-x
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4132: Show issues Location:
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  5. Article ; Online: Viral cultures, Polymerase Chain Reaction Cycle Threshold Values and Viral Load Estimation for SARS-CoV-2 Infectious Potential Assessment in Hematopoietic Stem Cell and Solid Organ Transplant Patients: A Systematic Review

    Jefferson, Tom / Spencer, Elizabeth A / Rosca, Elena Cecilia / Maltoni, Susanna / Brassey, Jon / ONAKPOYA, IGHO / Pluddemann, Annette / Evans, David H / Conly, John M / Heneghan, Carl

    medRxiv

    Abstract: ... a relationship between proxies of viral burden and likelihood of shedding replication-competent SARS-CoV-2 ... Background: Organ transplant recipients are at increased vulnerability to SARS-CoV-2 due ... a systematic review to investigate the relationship in transplant recipients between serial SARS-CoV-2 RT-PCR ...

    Abstract Background: Organ transplant recipients are at increased vulnerability to SARS-CoV-2 due to immunosuppression and may pose a continued transmission risk especially within hospital settings. Detailed case reports including symptoms, viral load and infectiousness, defined by the presence of replication-competent viruses in culture, provide an opportunity to examine the relationship between clinical course, burden and contagiousness, and provide guidance on release from isolation. Objectives: We performed a systematic review to investigate the relationship in transplant recipients between serial SARS-CoV-2 RT-PCR cycle threshold (Ct) value or cycle of quantification value (Cq), or other measures of viral burden and the likelihood and duration of the presence of infectious virus based on viral culture including the influence of age, sex, underlying pathologies, degree of immunosuppression, and/or vaccination on this relationship. Methods: We searched LitCovid, medRxiv, Google Scholar and WHO Covid-19 databases, from 1 November 2019 until 31 December 2021. We included studies reporting relevant data for transplantees with SARS-CoV-2 infection: results from serial RT-PCR testing and viral culture data from the same respiratory samples. We assessed methodological quality using five criteria, and synthesised the data narratively and graphically. Results: We included 9 case reports and case series reporting on 30 transplantees. We observed a relationship between proxies of viral burden and likelihood of shedding replication-competent SARS-CoV-2 particles. Two individuals shed replication-competent particles over 100 days after infection onset. Lack of standardisation of testing and reporting precludes establishing a viral burden cutoff. Most transplantees stopped shedding competent particles when the RT-PCR cycle threshold was above 30, but there are differences across platforms. Conclusions Viral burden is a reasonable proxy for infectivity when considered within the context of the clinical status of each patient. Standardised study design and reporting are essential to avoid research waste and generate guidance based on an increasing evidence base.
    Keywords covid19
    Language English
    Publishing date 2022-03-02
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.03.01.22271684
    Database COVID19

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  6. Article ; Online: Strategy To Assess Zoonotic Potential Reveals Low Risk Posed by SARS-Related Coronaviruses from Bat and Pangolin.

    Yang, Yong / Shen, Xu-Rui / Zhang, Yu-Lan / Jiang, Ren-di / Wang, Xi / Guan, Zhen-Qiong / Li, Qian / Yao, Yu-Lin / Gong, Qian-Chun / Geng, Rong / Wang, Qi / Zhu, Yan / Luo, Jing-Yi / Shi, Zheng-Li / Zhang, Hui-Lan / Peng, Ke / Zhou, Peng

    mBio

    2023  Volume 14, Issue 2, Page(s) e0328522

    Abstract: ... severe acute respiratory syndrome (SARS)-related coronavirus (SARSr-CoV) is important in the context of future disease preparedness ... of an animal SARSr-CoV by testing how viruses break through key human immune barriers, including viral cell ... tropism, replication dynamics, interferon signaling, inflammation, and adaptive immune barriers, using ...

    Abstract In the last 2 decades, pathogens originating in animals may have triggered three coronavirus pandemics, including the coronavirus disease 2019 pandemic. Thus, evaluation of the spillover risk of animal severe acute respiratory syndrome (SARS)-related coronavirus (SARSr-CoV) is important in the context of future disease preparedness. However, there is no analytical framework to assess the spillover risk of SARSr-CoVs, which cannot be determined by sequence analysis alone. Here, we established an integrity framework to evaluate the spillover risk of an animal SARSr-CoV by testing how viruses break through key human immune barriers, including viral cell tropism, replication dynamics, interferon signaling, inflammation, and adaptive immune barriers, using human
    MeSH term(s) Animals ; Humans ; Pangolins ; Chiroptera ; SARS-CoV-2 ; COVID-19 ; Zoonoses ; Interferons ; Phylogeny
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03285-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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