Article ; Online: Infection with highly pathogenic H7 influenza viruses results in an attenuated proinflammatory cytokine and chemokine response early after infection.
The Journal of infectious diseases
2010 Volume 203, Issue 1, Page(s) 40–48
Abstract: ... since 2002. Highly pathogenic avian influenza (HPAI) H7 viruses have the capacity to cause severe ... monocyte-derived macrophages. Here, we show that infection with HPAI H7 viruses resulted in a delayed and weakened production ... Avian influenza A viruses of the H7 subtype have resulted in more than 100 cases of human infection ...
| Abstract | Avian influenza A viruses of the H7 subtype have resulted in more than 100 cases of human infection since 2002. Highly pathogenic avian influenza (HPAI) H7 viruses have the capacity to cause severe respiratory disease and even death; however, the induction of the human innate immune response to H7 virus infection has not been well characterized. To better understand H7 virus pathogenesis in the human respiratory tract, we employed a polarized human bronchial epithelial cell model and primary human monocyte-derived macrophages. Here, we show that infection with HPAI H7 viruses resulted in a delayed and weakened production of cytokines, including the type I interferon response, compared with infections of other influenza A subtypes, including H7 viruses of low pathogenicity. These studies revealed that H7 viruses vary greatly in their ability to activate host innate responses and may contribute to the virulence of these viruses observed in humans. |
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| MeSH term(s) | Adolescent ; Adult ; Cell Death ; Cells, Cultured ; Cytokines/biosynthesis ; Cytokines/immunology ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Gene Expression Profiling ; Humans ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Influenza, Human/immunology ; Influenza, Human/virology ; Macrophages/immunology ; Macrophages/virology ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Virulence ; Young Adult | ||||||||||
| Chemical Substances | Cytokines ; RNA, Messenger | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2010-12-09 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Comparative Study ; Journal Article | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1093/infdis/jiq018 | ||||||||||
| Shelf mark |
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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