Article ; Online: Stimulus-secretion coupling by high-affinity IgE receptor: new developments.
2010 Volume 584, Issue 24, Page(s) 4941–4948
Abstract: Stimulation of mast cells through their high affinity IgE receptor (FcεRI) leads to the secretion ... We describe here some of the new developments that have allowed to obtain a clearer picture of stimulus ... have led to the discovery of a series of new effector molecules that link FcεRI to secretion ...
| Abstract | Stimulation of mast cells through their high affinity IgE receptor (FcεRI) leads to the secretion of pre- and neoformed soluble mediators through vesicular carriers. This process is highly regulated in order to adapt the secretion of these potentially dangerous factors to the physiological needs. This regulation requires numerous essential effectors that are necessary to transmit the initial signal of FcεRI aggregation and couple it to the sophisticated secretory machinery of membrane fusion. Studies in recent years have led to the discovery of a series of new effector molecules that link FcεRI to secretion. We describe here some of the new developments that have allowed to obtain a clearer picture of stimulus/secretion coupling in mast cells. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Humans ; Mast Cells/enzymology ; Mast Cells/metabolism ; Membrane Fusion ; Phospholipid Transfer Proteins/metabolism ; Receptors, IgE/metabolism ; SNARE Proteins/metabolism ; Signal Transduction | |||||
| Chemical Substances | PLSCR1 protein, human ; Phospholipid Transfer Proteins ; Receptors, IgE ; SNARE Proteins | |||||
| Language | English | |||||
| Publishing date | 2010-12-15 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 212746-5 | |||||
| ISSN | 1873-3468 ; 0014-5793 | |||||
| ISSN (online) | 1873-3468 | |||||
| ISSN | 0014-5793 | |||||
| DOI | 10.1016/j.febslet.2010.09.023 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.B 282: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.