Article ; Online: Potential Risks and Benefits of Multiple Sclerosis Immune Therapies in the COVID-19 Era: Clinical and Immunological Perspectives.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2021 Volume 18, Issue 1, Page(s) 244–251
Abstract: ... behind these treatments and their impact on COVID-19, as well as the current recommendations ... individuals on long-term B cell-depleting therapies may have diminished immune responses to vaccination, based ... treatments and continuation of therapy. Additionally, vaccinations must be considered carefully, and ...
| Abstract | Coronavirus SARS-CoV2 has emerged as one of the greatest infectious disease health challenges in a century. Patients with multiple sclerosis (MS) have a particular vulnerability to infections through their use of immunosuppressive disease-modifying therapies (DMTs). Specific DMTs pose particular risk based on their mechanisms of action (MOA). As a result, patients require individualized approaches to starting new treatments and continuation of therapy. Additionally, vaccinations must be considered carefully, and individuals on long-term B cell-depleting therapies may have diminished immune responses to vaccination, based on preserved T cells and diminished but present antibody titers to influenza vaccines. We review the immunology behind these treatments and their impact on COVID-19, as well as the current recommendations for best practices for use of DMTs in patients with MS. |
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| MeSH term(s) | Antirheumatic Agents/adverse effects ; COVID-19 ; Humans ; Immunosuppressive Agents/therapeutic use ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Multiple Sclerosis/complications ; Multiple Sclerosis/therapy ; Pandemics ; Risk Assessment | |||||
| Chemical Substances | Antirheumatic Agents ; Immunosuppressive Agents | |||||
| Language | English | |||||
| Publishing date | 2021-02-02 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 2316693-9 | |||||
| ISSN | 1878-7479 ; 1933-7213 | |||||
| ISSN (online) | 1878-7479 | |||||
| ISSN | 1933-7213 | |||||
| DOI | 10.1007/s13311-021-01008-7 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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