Article: Are COVID-19 mitigation measures reducing preterm birth rate in China?
BMJ global health
2021 Volume 6, Issue 8
Abstract: ... decreases in preterm birth rates were observed following implementation of the national COVID-19 mitigation ... to determine the impact of the COVID-19 mitigation measures implemented in China on 23 January 2020 ... to investigate the association between the national COVID-19 mitigation measures implemented in China and ...
| Abstract | Objective: Preterm birth is the leading cause of child morbidity and mortality globally. We aimed to determine the impact of the COVID-19 mitigation measures implemented in China on 23 January 2020 on the incidence of preterm birth in our institution. Design: Logistic regression analysis was used to investigate the association between the national COVID-19 mitigation measures implemented in China and the incidence of preterm birth. Setting: Shanghai First Maternity and Infant Hospital, Shanghai China. Participants: All singleton deliveries abstracted from electronic medical record between 1 January 2014 to 31 December 2020. Main outcome measures: Preterm birth rate. Results: Data on 164 107 singleton deliveries were available. COVID-19 mitigation measures were consistently associated with significant reductions in preterm birth in the 2-month, 3-month, 4-month, 5-month time windows after implementation (+2 months, OR 0.80, 95% CI 0.69 to 0.94; +3 months, OR 0.83, 95% CI 0.73 to 0.94; +4 months, OR 0.82, 95% CI 0.73 to 0.92; +5 months, OR 0.84, 95% CI 0.76 to 0.93). These reductions in preterm birth were obvious across various degrees of prematurity, but were statistically significant only in moderate-to-late preterm birth (32 complete weeks to 36 weeks and 6 days) subgroup. The preterm birth difference disappeared gradually after various restrictions were removed (7th-12th month of 2020, OR 1.02, 95% CI 0.94 to 1.11). There was no difference in stillbirth rate across the study time window. Conclusion: Substantial decreases in preterm birth rates were observed following implementation of the national COVID-19 mitigation measures in China. Further study is warranted to explore the underlying mechanisms associated with this observation. |
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| MeSH term(s) | Birth Rate ; COVID-19 ; Child ; China/epidemiology ; Female ; Humans ; Infant ; Infant, Newborn ; Pregnancy ; Premature Birth/epidemiology ; Premature Birth/prevention & control ; SARS-CoV-2 |
| Language | English |
| Publishing date | 2021-08-06 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2059-7908 |
| ISSN | 2059-7908 |
| DOI | 10.1136/bmjgh-2021-006359 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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