Article ; Online: ENDOGENOUS ENDOPHTHALMITIS IN THE SETTING OF COVID-19 INFECTION: A Case Series.
2021 Volume 41, Issue 8, Page(s) 1709–1714
Abstract: ... of early intervention for endogenous endophthalmitis in the setting of COVID-19 infection. We also document the presence ... Purpose: To describe endogenous endophthalmitis in the setting of COVID-19 pneumonia.: Methods ... collected for analysis.: Results: Three patients with endogenous endophthalmitis were identified ...
| Abstract | Purpose: To describe endogenous endophthalmitis in the setting of COVID-19 pneumonia. Methods: Patients recovering from COVID-19 pneumonia who presented to our department with any or all of the following complaints: pain, watering, redness, and decreased vision were identified. All relevant data were collected for analysis. Results: Three patients with endogenous endophthalmitis were identified. All patients had been treated for COVID-19 pneumonia and therefore had received remdesivir and systemic steroids; 2 of the 3 patients received tocilizumab. All patients received vitreous biopsy, vitrectomy, and intraocular antibiotic injection. Patient 1 demonstrated Klebsiella pneumoniae in blood culture, K. pneumoniae and Escherichia coli in urine culture, and K. pneumoniae in vitreous fluid, whereas Patients 2 and 3 demonstrated Stenotrophomonas maltophilia and methicillin-resistant Staphylococcus aureus in the blood and nasopharyngeal culture, respectively. Correspondingly, the same organism was cultured from vitreous in Patients 2 and 3. The visual acuity at the last follow-up in Patients 1 to 3 was 20/100, 20/80, and 20/40, respectively. The probable source of infection was identified in each as renal calculi, dental caries, and the pharynx, respectively. Real-time polymerase chain reaction demonstrated the presence of Severe Acute Respiratory Syndrome Coronavirus 2 in the vitreous fluid of Patient 1. Conclusion: We report good outcomes of early intervention for endogenous endophthalmitis in the setting of COVID-19 infection. We also document the presence of SARS-CoV-2 in vitreous. |
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| MeSH term(s) | Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; COVID-19/complications ; COVID-19 Nucleic Acid Testing ; Endophthalmitis/diagnosis ; Endophthalmitis/drug therapy ; Endophthalmitis/microbiology ; Eye Infections, Bacterial/diagnosis ; Eye Infections, Bacterial/drug therapy ; Eye Infections, Bacterial/microbiology ; Female ; Glucocorticoids/therapeutic use ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Klebsiella Infections/diagnosis ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/isolation & purification ; Male ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Middle Aged ; SARS-CoV-2/isolation & purification ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Stenotrophomonas maltophilia/isolation & purification ; Vitrectomy ; Vitreous Body/microbiology ; Vitreous Body/virology | |||||
| Chemical Substances | Anti-Bacterial Agents ; Glucocorticoids | |||||
| Language | English | |||||
| Publishing date | 2021-02-19 | |||||
| Publishing country | United States | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 603192-4 | |||||
| ISSN | 1539-2864 ; 0275-004X | |||||
| ISSN (online) | 1539-2864 | |||||
| ISSN | 0275-004X | |||||
| DOI | 10.1097/IAE.0000000000003168 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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