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  1. Article: Antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid.

    Billiau, A / Desmyter, J / De Somer, P

    Journal of virology

    1970  Volume 5, Issue 3, Page(s) 321–328

    Abstract: Intraperitoneal injection of chlorite-oxidized oxyamylose (COAM) protected mice against mengo ... polyacrylic acid in many aspects, but it was markedly less toxic. For systemic administration, the therapeutic ... wore off faster than that of polyacrylic acid, protection lasted for several weeks. Against mengovirus ...

    Abstract Intraperitoneal injection of chlorite-oxidized oxyamylose (COAM) protected mice against mengo, vaccinia, Semliki Forest, and influenza APR8 viruses. Topical administration in the eye of rabbits partially inhibited the development of experimental herpetic keratoconjunctivitis. COAM resembled polyacrylic acid in many aspects, but it was markedly less toxic. For systemic administration, the therapeutic index was on the order of magnitude of 1:300 to 1:500. Although the in vivo antiviral effect of COAM wore off faster than that of polyacrylic acid, protection lasted for several weeks. Against mengovirus, such prolonged protection was achieved only when polymer and virus were injected intraperitoneally. Protection against intravenous vaccinia virus was not dependent on the injection route of COAM. Experiments on the mode of action of COAM pointed to macrophages as possible mediators of the antiviral effect. The fact that small amounts of interferon appeared in the serum after administration of high doses of COAM suggests that interferon may play a role in the induction of antiviral resistance by COAM.
    MeSH term(s) Acids ; Animals ; Antiviral Agents/therapeutic use ; Arbovirus Infections/prevention & control ; Arboviruses/drug effects ; Encephalomyocarditis virus/drug effects ; Female ; Herpesviridae/drug effects ; Herpesviridae Infections/prevention & control ; Injections, Intraperitoneal ; Injections, Intravenous ; Injections, Subcutaneous ; Interferons/blood ; Keratoconjunctivitis/prevention & control ; Macrophages ; Mice ; Newcastle Disease/prevention & control ; Newcastle disease virus/drug effects ; Orthomyxoviridae/drug effects ; Orthomyxoviridae Infections/prevention & control ; Polymers ; Polysaccharides/therapeutic use ; Rabbits ; Semliki forest virus/drug effects ; Vaccinia/prevention & control ; Vaccinia virus/drug effects ; Virus Diseases/prevention & control
    Chemical Substances Acids ; Antiviral Agents ; Polymers ; Polysaccharides ; Interferons (9008-11-1)
    Language English
    Publishing date 1970-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.5.3.321-328.1970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Polyacetal carboxylic acids: a new group of antiviral polyanions.

    Claes, P / Billiau, A / De Clercq, E / Desmyter, J / Schonne, E / Vanderhaeghe, H / De Somer, P

    Journal of virology

    1970  Volume 5, Issue 3, Page(s) 313–320

    Abstract: Chlorite-oxidized oxypolysaccharides are polyacetal carboxylic acids. They inhibited the cytopathic ... of experimental pox lesions on the tail. Chlorite-oxidized oxyamylose was antiviral only when at least 64 ... by the fact that chlorite-oxidized dextrans which had a high intrinsic viscosity were more active ...

    Abstract Chlorite-oxidized oxypolysaccharides are polyacetal carboxylic acids. They inhibited the cytopathic effect of vesicular stomatitis virus in mouse embryo cell cultures challenged at low input multiplicity. After intraperitoneal injection of these compounds in mice, interferon appeared in the circulation. The compounds also protected mice against lethal mengovirus infection and against the development of experimental pox lesions on the tail. Chlorite-oxidized oxyamylose was antiviral only when at least 64% of the glucopyranose units were oxidized, an observation which suggested a correlation between charge density and antiviral effect. The antiviral activity was also influenced by the molecular weight, as demonstrated by the fact that chlorite-oxidized dextrans which had a high intrinsic viscosity were more active than those with low intrinsic viscosity.
    MeSH term(s) Acids ; Acrylates/pharmacology ; Amylose/analogs & derivatives ; Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Arbovirus Infections/prevention & control ; Chemical Phenomena ; Chemistry ; Culture Techniques ; Cytopathogenic Effect, Viral ; Embryo, Mammalian ; Encephalomyocarditis virus ; Fibroblasts ; Injections, Intraperitoneal ; Interferons/blood ; Mice ; Polymers ; Polysaccharides/chemical synthesis ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Vaccinia/prevention & control ; Vesicular stomatitis Indiana virus/drug effects
    Chemical Substances Acids ; Acrylates ; Antiviral Agents ; Polymers ; Polysaccharides ; oxyamylose ; Amylose (9005-82-7) ; Interferons (9008-11-1)
    Language English
    Publishing date 1970-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.5.3.313-320.1970
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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