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  1. Article: Investigation of Coagulation Biomarkers to Assess Clinical Deterioration in SARS-CoV-2 Infection.

    Billoir, Paul / Alexandre, Kevin / Duflot, Thomas / Roger, Maxime / Miranda, Sébastien / Goria, Odile / Joly, Luc Marie / Demeyere, Mathieu / Feugray, Guillaume / Brunel, Valery / Etienne, Manuel / Le Cam Duchez, Véronique

    Frontiers in medicine

    2021  Volume 8, Page(s) 670694

    Abstract: ... to investigate the association of coagulation activation in COVID-19 progression. Thirty-five of the 99 patients ... got clinically worse. The final model of the logistic regression analysis revealed that O ...

    Abstract Since December 2019, a pandemic caused by a new coronavirus has spread to more than 170 countries around the world. Worsening infected patients requiring intensive care unit (ICU) admission associated with 30% of mortality. A part of worsening is induced by hemostasis deregulation. The aim of this study was to investigate the association of coagulation activation in COVID-19 progression. Thirty-five of the 99 patients got clinically worse. The final model of the logistic regression analysis revealed that O
    Language English
    Publishing date 2021-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.670694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigation of Coagulation Biomarkers to Assess Clinical Deterioration in SARS-CoV-2 Infection

    Paul Billoir / Kevin Alexandre / Thomas Duflot / Maxime Roger / Sébastien Miranda / Odile Goria / Luc Marie Joly / Mathieu Demeyere / Guillaume Feugray / Valery Brunel / Manuel Etienne / Véronique Le Cam Duchez

    Frontiers in Medicine, Vol

    2021  Volume 8

    Abstract: ... we identified fibrinogen and thrombin peak at admission as coagulation biomarkers associated with an increased ... of clinical worsening. A fibrinogen level threshold of 5.5 g/L, a thrombin peak measurement threshold of 99 pM ... and O2 requirement associated with clinical outcome in more than 80% of our cohort. In conclusion ...

    Abstract Since December 2019, a pandemic caused by a new coronavirus has spread to more than 170 countries around the world. Worsening infected patients requiring intensive care unit (ICU) admission associated with 30% of mortality. A part of worsening is induced by hemostasis deregulation. The aim of this study was to investigate the association of coagulation activation in COVID-19 progression. Thirty-five of the 99 patients got clinically worse. The final model of the logistic regression analysis revealed that O2 requirement (RR = 7.27 [1.50–19.31]), monocytes below 0.2G/L (RR = 2.88 [1.67–3.19]), fibrinogen levels (RR = 1.45 [1.17–1.82] per g/L increase), prothrombin fragments 1+2 higher than 290 pM (RR = 2.39 [1.20–3.30]), and thrombin peak (RR = 1.28 [1.03–1.59] per 50 nM increase) were associated with an increased risk of clinical worsening. A fibrinogen level threshold of 5.5 g/L, a thrombin peak measurement threshold of 99 pM, and O2 requirement associated with clinical outcome in more than 80% of our cohort. In conclusion, we identified fibrinogen and thrombin peak at admission as coagulation biomarkers associated with an increased risk of ICU admission or death. This finding allows initiating steroids and triage for worsening patients. Our results should therefore be considered as exploratory and deserve confirmation.
    Keywords COVID-19 ; intensive care ; hypercoagulability ; fibrinogen ; thrombin generation ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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