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  1. Article ; Online: Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID-19.

    Biolè, Carloalberto / Bianco, Matteo / Núñez-Gil, Iván J / Cerrato, Enrico / Spirito, Amanda / Roubin, Sergio Raposeiras / Viana-Llamas, María C / Gonzalez, Adelina / Castro-Mejía, Alex F / Eid, Charbel Maroun / Fernández-Pérez, Cristina / Uribarri, Aitor / Alfonso-Rodriguez, Emilio / Ugo, Fabrizio / Guerra, Federico / Feltes, Gisela / Akin, Ibrahim / Fernández-Rozas, Inmaculada / Blasco-Angulo, Natividad /
    Huang, Jia / Aguado, Marcos Garcia / Pepe, Martino / Romero, Rodolfo / Becerra-Muñoz, Víctor Manuel / Estrada, Vicente / Macaya, Carlos

    Journal of hospital medicine

    2021  Volume 16, Issue 6, Page(s) 349–352

    Abstract: ... outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enrolled ... Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality ... COVID-19 infection (eg, significantly higher C-reactive protein, troponin, transaminases ...

    Abstract Gender-related differences in COVID-19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE-COVID-19 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular risk factors and more comorbidities at baseline. After propensity score matching, 876 men and 876 women were selected. Male patients more often reported fever, whereas female patients more often reported vomiting, diarrhea, and hyposmia/anosmia. Laboratory tests in men presented alterations consistent with a more severe COVID-19 infection (eg, significantly higher C-reactive protein, troponin, transaminases, lymphocytopenia, thrombocytopenia, and ferritin). Systemic inflammatory response syndrome, bilateral pneumonia, respiratory insufficiency, and renal failure were significantly more frequent in men. Men more often required pronation, corticosteroids, and tocilizumab administration. A significantly higher 30-day mortality was observed in men vs women (23.4% vs 19.2%; P = .039). Trial Numbers: NCT04334291/EUPAS34399.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/mortality ; Cohort Studies ; Comorbidity ; Disease Progression ; Female ; Heart Disease Risk Factors ; Hospitalization ; Humans ; Male ; Middle Aged ; Sex Factors
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.12788/jhm.3594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6276: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 542: Show issues

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  2. Article: Sex and gender differences in COVID testing, hospital admission, presentation, and drivers of severe outcomes in the DC/Maryland region.

    Scully, Eileen P / Schumock, Grant / Fu, Martina / Massaccesi, Guido / Muschelli, John / Betz, Joshua / Klein, Eili Y / West, Natalie E / Robinson, Matthew / Garibaldi, Brian T / Bandeen-Roche, Karen / Zeger, Scott / Klein, Sabra L / Gupta, Amita

    medRxiv : the preprint server for health sciences

    2021  

    Abstract: ... risk of severe outcomes and death for males in COVID-19.: Trial registration: NA.: Funding ... but the mechanisms for this difference are unclear. Understanding the differences in outcomes between males and ... Of 2,626 hospitalized individuals, females had less severe presenting respiratory parameters and males ...

    Abstract Background: Rates of severe illness and mortality from SARS-CoV-2 are greater for males, but the mechanisms for this difference are unclear. Understanding the differences in outcomes between males and females across the age spectrum will guide both public health and biomedical interventions.
    Methods: Retrospective cohort analysis of SARS-CoV-2 testing and admission data in a health system. Patient-level data were assessed with descriptive statistics and logistic regression modeling was used to identify features associated with increased male risk of severe outcomes.
    Results: In 213,175 SARS-CoV-2 tests, despite similar positivity rates (8.2%F vs 8.9%M), males were more frequently hospitalized (28%F vs 33%M). Of 2,626 hospitalized individuals, females had less severe presenting respiratory parameters and males had more fever. Comorbidity burden was similar, but with differences in specific conditions. Medications relevant for SARS-CoV-2 were used at similar frequency except tocilizumab (M>F). Males had higher inflammatory lab values. In a logistic regression model, male sex was associated with a higher risk of severe outcomes at 24 hours (odds ratio (OR) 3.01, 95%CI 1.75, 5.18) and at peak status (OR 2.58, 95%CI 1.78,3.74) among 18-49 year-olds. Block-wise addition of potential explanatory variables demonstrated that only the inflammatory labs substantially modified the OR associated with male sex across all ages.
    Conclusion: Higher levels of clinical inflammatory labs are the only features that are associated with the heightened risk of severe outcomes and death for males in COVID-19.
    Trial registration: NA.
    Funding: Hopkins inHealth; COVID-19 Administrative Supplement (HHS Region 3 Treatment Center), Office of the ASPR; NIH/NCI U54CA260492 (SK), NIH/NIA U54AG062333 (SK).
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.04.05.21253827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel Coronavirus Disease (COVID-19) in Italian Patients: Gender Differences in Presentation and Severity.

    Baiardo Redaelli, Martina / Landoni, Giovanni / Di Napoli, Davide / Morselli, Federica / Sartorelli, Marianna / Sartini, Chiara / Ruggeri, Annalisa / Salonia, Andrea / Dagna, Lorenzo / Zangrillo, Alberto

    Saudi journal of medicine & medical sciences

    2020  Volume 9, Issue 1, Page(s) 59–62

    Abstract: ... related differences in presentation and severity among COVID-19 patients admitted to IRCCS San Raffaele Hospital ... of intensive care unit admission and outcomes.: Results: A total of 901 patients with COVID-19 were admitted ... of the first wave of COVID-19 pandemic in Italy, female patients were few, presented late and were less ...

    Abstract Background: In the first wave of the novel coronavirus (severe acute respiratory syndrome coronavirus 2) infections, Italy experienced a heavy burden of hospital admissions for acute respiratory distress syndromes associated with the novel coronavirus disease (COVID-19). Early evidence suggested that females are less affected than males.
    Objective: This study aimed to assess the gender-related differences in presentation and severity among COVID-19 patients admitted to IRCCS San Raffaele Hospital, Milan, Italy.
    Materials and methods: This prospective observational study included all patients admitted to the hospital between February 25 and April 19, 2020, with a positive real-time reverse-transcriptase polymerase chain reaction for COVID-19. The following data were collected: date of admission, gender, age and details of intensive care unit admission and outcomes.
    Results: A total of 901 patients with COVID-19 were admitted to the hospital and provided consent for the study. Of these, 284 were female (31.5%). The percentage of admitted female patients significantly increased over time (25.9% of all admissions in the first half of the study period vs. 37.1% in the second half;
    Conclusions: In our hospital, which was in the epicenter of the first wave of COVID-19 pandemic in Italy, female patients were few, presented late and were less critical than male patients.
    Language English
    Publishing date 2020-12-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2734896-9
    ISSN 2321-4856 ; 2321-4856
    ISSN (online) 2321-4856
    ISSN 2321-4856
    DOI 10.4103/sjmms.sjmms_542_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Sex and gender differences in COVID testing, hospital admission, presentation, and drivers of severe outcomes in the DC/Maryland region

    Scully, Eileen P. / Schumock, Grant / Fu, Martina / Massaccesi, Guido / Muschelli, John / Betz, Joshua / Klein, Eili Y. / West, Natalie E. / Robinson, Matthew L. / Garibaldi, Brian T / Bandeen- Roche, Karen / Zeger, Scott / Klein, Sabra L. / Gupta, Amita

    medRxiv

    Abstract: ... of severe outcomes and death for males in COVID-19. ... but the mechanisms for this difference are unclear. Understanding the differences in outcomes between males and ... Of 2,626 hospitalized individuals, females had less severe presenting respiratory parameters and males ...

    Abstract Background. Rates of severe illness and mortality from SARS-CoV-2 are greater for males, but the mechanisms for this difference are unclear. Understanding the differences in outcomes between males and females across the age spectrum will guide both public health and biomedical interventions. Methods. Retrospective cohort analysis of SARS-CoV-2 testing and admission data in a health system. Patient-level data were assessed with descriptive statistics and logistic regression modeling was used to identify features associated with increased male risk of severe outcomes. Results. In 213,175 SARS-CoV-2 tests, despite similar positivity rates (8.2%F vs 8.9%M), males were more frequently hospitalized (28%F vs 33%M). Of 2,626 hospitalized individuals, females had less severe presenting respiratory parameters and males had more fever. Comorbidity burden was similar, but with differences in specific conditions. Medications relevant for SARS-CoV-2 were used at similar frequency except tocilizumab (M>F). Males had higher inflammatory lab values. In a logistic regression model, male sex was associated with a higher risk of severe outcomes at 24 hours (odds ratio (OR) 3.01, 95%CI 1.75, 5.18) and at peak status (OR 2.58, 95%CI 1.78,3.74) among 18-49 year-olds. Block-wise addition of potential explanatory variables demonstrated that only the inflammatory labs substantially modified the OR associated with male sex across all ages. Conclusion. Higher levels of clinical inflammatory labs are the only features that are associated with the heightened risk of severe outcomes and death for males in COVID-19.
    Keywords covid19
    Language English
    Publishing date 2021-04-07
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.04.05.21253827
    Database COVID19

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  5. Article ; Online: Novel Coronavirus Disease (COVID-19) in Italian Patients

    Martina Baiardo Redaelli / Giovanni Landoni / Davide Di Napoli / Federica Morselli / Marianna Sartorelli / Chiara Sartini / Annalisa Ruggeri / Andrea Salonia / Lorenzo Dagna / Alberto Zangrillo

    Saudi Journal of Medicine and Medical Sciences, Vol 9, Iss 1, Pp 59-

    Gender Differences in Presentation and Severity

    2021  Volume 62

    Abstract: ... in presentation and severity among COVID-19 patients admitted to IRCCS San Raffaele Hospital, Milan, Italy ... of intensive care unit admission and outcomes. Results: A total of 901 patients with COVID-19 were admitted ... of the first wave of COVID-19 pandemic in Italy, female patients were few, presented late and were less ...

    Abstract Background: In the first wave of the novel coronavirus (severe acute respiratory syndrome coronavirus 2) infections, Italy experienced a heavy burden of hospital admissions for acute respiratory distress syndromes associated with the novel coronavirus disease (COVID-19). Early evidence suggested that females are less affected than males. Objective: This study aimed to assess the gender-related differences in presentation and severity among COVID-19 patients admitted to IRCCS San Raffaele Hospital, Milan, Italy. Materials and Methods: This prospective observational study included all patients admitted to the hospital between February 25 and April 19, 2020, with a positive real-time reverse-transcriptase polymerase chain reaction for COVID-19. The following data were collected: date of admission, gender, age and details of intensive care unit admission and outcomes. Results: A total of 901 patients with COVID-19 were admitted to the hospital and provided consent for the study. Of these, 284 were female (31.5%). The percentage of admitted female patients significantly increased over time (25.9% of all admissions in the first half of the study period vs. 37.1% in the second half; P < 0.001). Females accounted for 14.4% of all COVID-19 intensive care unit admissions. There was no gender-based difference in the overall hospital mortality: 20.1% for females and 19.2% for males (P = 0.8). Conclusions: In our hospital, which was in the epicenter of the first wave of COVID-19 pandemic in Italy, female patients were few, presented late and were less critical than male patients.
    Keywords covid-19 ; critical care ; gender ; intensive care unit ; italy ; severity ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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