Article ; Online: Nucleocytoplasmic mRNP export is an integral part of mRNP biogenesis.
2010 Volume 120, Issue 1, Page(s) 23–38
Abstract: Nucleocytoplasmic export and biogenesis of mRNPs are closely coupled. At the gene, concomitant ... export machineries cooperate to release processed and export competent mRNPs. After diffusion ... Processes taking place at the gene locus and at the nuclear pore complex are crucial for integrating export ...
| Abstract | Nucleocytoplasmic export and biogenesis of mRNPs are closely coupled. At the gene, concomitant with synthesis of the pre-mRNA, the transcription machinery, hnRNP proteins, processing, quality control and export machineries cooperate to release processed and export competent mRNPs. After diffusion through the interchromatin space, the mRNPs are translocated through the nuclear pore complex and released into the cytoplasm. At the nuclear pore complex, defined compositional and conformational changes are triggered, but specific cotranscriptionally added components are retained in the mRNP and subsequently influence the cytoplasmic fate of the mRNP. Processes taking place at the gene locus and at the nuclear pore complex are crucial for integrating export as an essential part of gene expression. Spatial, temporal and structural aspects of these events have been highlighted in analyses of the Balbiani ring genes. |
|---|---|
| MeSH term(s) | Animals ; Biological Transport/physiology ; Chromosomal Puffs/metabolism ; Cytoplasm/metabolism ; Humans ; Nuclear Pore/metabolism ; RNA Precursors/metabolism ; RNA Processing, Post-Transcriptional/physiology ; Ribonucleoproteins/metabolism |
| Chemical Substances | RNA Precursors ; Ribonucleoproteins ; messenger ribonucleoprotein |
| Language | English |
| Publishing date | 2010-11-16 |
| Publishing country | Austria |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 203083-4 |
| ISSN | 1432-0886 ; 0009-5915 |
| ISSN (online) | 1432-0886 |
| ISSN | 0009-5915 |
| DOI | 10.1007/s00412-010-0298-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Ub I Zs.94/5: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.