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Article ; Online: Neutrophils: Beneficial and Harmful Cells in Septic Arthritis.

Boff, Daiane / Crijns, Helena / Teixeira, Mauro M / Amaral, Flavio A / Proost, Paul

International journal of molecular sciences

2018 Volume 19, Issue 2

Abstract: Septic arthritis is an inflammatory joint disease that is induced by pathogens such as ...

Abstract	Septic arthritis is an inflammatory joint disease that is induced by pathogens such as
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Arthritis, Infectious/immunology ; Arthritis, Infectious/microbiology ; Arthritis, Infectious/surgery ; Arthritis, Infectious/therapy ; Arthrocentesis/methods ; Arthroscopy/methods ; Cell Movement/immunology ; Chemokines/immunology ; Chemokines/metabolism ; Humans ; Inflammation ; Joints/drug effects ; Joints/immunology ; Joints/microbiology ; Joints/surgery ; Leukotrienes/immunology ; Leukotrienes/metabolism ; Neutrophil Infiltration/drug effects ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/pathology ; Staphylococcal Infections/immunology ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/surgery ; Staphylococcal Infections/therapy ; Staphylococcus aureus ; Suction/methods
Chemical Substances	Anti-Bacterial Agents ; Chemokines ; Leukotrienes
Language	English
Publishing date	2018-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19020468
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neutrophils

Daiane Boff / Helena Crijns / Mauro M. Teixeira / Flavio A. Amaral / Paul Proost

International Journal of Molecular Sciences, Vol 19, Iss 2, p

Beneficial and Harmful Cells in Septic Arthritis

2018 Volume 468

Abstract: ... from the infectious agent or dying cells, host-derived leukotrienes, complement proteins and chemokines. Neutrophils ... are of major importance and play a dual role in the pathogenesis of septic arthritis. On the one hand ... Septic arthritis is an inflammatory joint disease that is induced by pathogens ...

Abstract	Septic arthritis is an inflammatory joint disease that is induced by pathogens such as Staphylococcus aureus. Infection of the joint triggers an acute inflammatory response directed by inflammatory mediators including microbial danger signals and cytokines and is accompanied by an influx of leukocytes. The recruitment of these inflammatory cells depends on gradients of chemoattractants including formylated peptides from the infectious agent or dying cells, host-derived leukotrienes, complement proteins and chemokines. Neutrophils are of major importance and play a dual role in the pathogenesis of septic arthritis. On the one hand, these leukocytes are indispensable in the first-line defense to kill invading pathogens in the early stage of disease. However, on the other hand, neutrophils act as mediators of tissue destruction. Since the elimination of inflammatory neutrophils from the site of inflammation is a prerequisite for resolution of the acute inflammatory response, the prolonged stay of these leukocytes at the inflammatory site can lead to irreversible damage to the infected joint, which is known as an important complication in septic arthritis patients. Thus, timely reduction of the recruitment of inflammatory neutrophils to infected joints may be an efficient therapy to reduce tissue damage in septic arthritis.
Keywords	neutrophil ; septic arthritis ; chemoattractant ; Staphylococcus aureus ; tissue damage ; infection ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2018-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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