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  1. Article ; Online: Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study.

    Bolondi, Giuliano / Russo, Emanuele / Gamberini, Emiliano / Circelli, Alessandro / Meca, Manlio Cosimo Claudio / Brogi, Etrusca / Viola, Lorenzo / Bissoni, Luca / Poletti, Venerino / Agnoletti, Vanni

    World journal of emergency surgery : WJES

    2020  Volume 15, Issue 1, Page(s) 41

    Abstract: ... Conclusions: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted ... soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 ... Background: Iron metabolism and immune response to SARS-CoV-2 have not been described ...

    Abstract Background: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis.
    Methods: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann-Whitney test. Trends over time were tested with the Kruskal-Wallis analysis.
    Results: Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 10
    Conclusions: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
    MeSH term(s) Aged ; Betacoronavirus/isolation & purification ; Blood Coagulation ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Correlation of Data ; Critical Care/methods ; Critical Care/statistics & numerical data ; Female ; Humans ; Intensive Care Units/statistics & numerical data ; Iron/metabolism ; Italy/epidemiology ; Lymphocyte Count/methods ; Lymphocyte Subsets ; Lymphocytes/immunology ; Male ; Middle Aged ; Mortality ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Severity of Illness Index ; Transferrin/analysis
    Chemical Substances Transferrin ; Iron (E1UOL152H7)
    Keywords covid19
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Journal Article ; Observational Study
    ISSN 1749-7922
    ISSN (online) 1749-7922
    DOI 10.1186/s13017-020-00323-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients:an observational cohort study

    Bolondi, Giuliano / Russo, Emanuele / Gamberini, Emiliano / Circelli, Alessandro / Meca, Manlio Cosimo Claudio / Brogi, Etrusca / Viola, Lorenzo / Bissoni, Luca / Poletti, Venerino / Agnoletti, Vanni

    Bolondi , G , Russo , E , Gamberini , E , Circelli , A , Meca , M C C , Brogi , E , Viola , L , Bissoni , L , Poletti , V & Agnoletti , V 2020 , ' Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients : an observational cohort study ' , World Journal of Emergency Surgery , vol. 15 , no. 1 , 41 . https://doi.org/10.1186/s13017-020-00323-2

    2020  

    Abstract: ... metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided ... soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 ... BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described ...

    Abstract BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. METHODS: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann-Whitney test. Trends over time were tested with the Kruskal-Wallis analysis. RESULTS: Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 109/L; interquartile range (IQR) 0.450 109/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither ferritin nor lymphocyte count follows significant trends in ICU patients. Transferrin saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at days 3 to 6 (median 33%, IQR 26.5%, p value 0.026). The same trend is observed with serum iron levels (median 25.5 μg/L, IQR 69 μg/L at admission; median 73 μg/L, IQR 56 μg/L on days 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing haemophagocytic lymphohistiocytosis. D-dimer is elevated and progressively increases from admission (median 1319 μg/L; IQR 1285 μg/L) to days 3 to 6 (median 6820 μg/L; IQR 6619 μg/L), despite not reaching significant results. We describe trends of all the abovementioned parameters during ICU stay. CONCLUSIONS: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
    Keywords Coagulation ; Coronavirus ; COVID-19 ; Critical care ; Ferritins ; Immunity ; Iron ; Lymphocytes ; Lymphopenia ; MeSH repository (3-10) ; SARS-CoV-2 ; covid19
    Subject code 610
    Language English
    Publishing country dk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study

    Bolondi, Giuliano / Russo, Emanuele / Gamberini, Emiliano / Circelli, Alessandro / Meca, Manlio Cosimo Claudio / Brogi, Etrusca / Viola, Lorenzo / Bissoni, Luca / Poletti, Venerino / Agnoletti, Vanni

    World J Emerg Surg

    Abstract: ... metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided ... soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 ... BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described ...

    Abstract BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. METHODS: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann-Whitney test. Trends over time were tested with the Kruskal-Wallis analysis. RESULTS: Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 109/L; interquartile range (IQR) 0.450 109/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither ferritin nor lymphocyte count follows significant trends in ICU patients. Transferrin saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at days 3 to 6 (median 33%, IQR 26.5%, p value 0.026). The same trend is observed with serum iron levels (median 25.5 µg/L, IQR 69 µg/L at admission; median 73 µg/L, IQR 56 µg/L on days 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing haemophagocytic lymphohistiocytosis. D-dimer is elevated and progressively increases from admission (median 1319 µg/L; IQR 1285 µg/L) to days 3 to 6 (median 6820 µg/L; IQR 6619 µg/L), despite not reaching significant results. We describe trends of all the abovementioned parameters during ICU stay. CONCLUSIONS: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #618185
    Database COVID19

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  4. Article ; Online: Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients

    Bolondi, Giuliano / Russo, Emanuele / Gamberini, Emiliano / Circelli, Alessandro / Meca, Manlio Cosimo Claudio / Brogi, Etrusca / Viola, Lorenzo / Bissoni, Luca / Poletti, Venerino / Agnoletti, Vanni

    World Journal of Emergency Surgery

    an observational cohort study

    2020  Volume 15, Issue 1

    Keywords Surgery ; Emergency Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ISSN 1749-7922
    DOI 10.1186/s13017-020-00323-2
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients

    Bolondi, Giuliano / Russo, Emanuele / Gamberini, Emiliano / Circelli, Alessandro / Meca, Manlio Cosimo Claudio / Brogi, Etrusca / Viola, Lorenzo / Bissoni, Luca / Poletti, Venerino / Agnoletti, Vanni

    World journal of emergency surgery, 15(1):41

    an observational cohort study

    2020  

    Abstract: ... metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided ... soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 ... BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described ...

    Abstract BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. METHODS: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann–Whitney test. Trends over time were tested with the Kruskal–Wallis analysis. RESULTS: Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 109/L; interquartile range (IQR) 0.450 109/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither ferritin nor lymphocyte count follows significant trends in ICU patients. Transferrin saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at days 3 to 6 (median 33%, IQR 26.5%, p value 0.026). The same trend is observed with serum iron levels (median 25.5 μg/L, IQR 69 μg/L at admission; median 73 μg/L, IQR 56 μg/L on days 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing haemophagocytic lymphohistiocytosis. D-dimer is elevated and progressively increases from admission (median 1319 μg/L; IQR 1285 μg/L) to days 3 to 6 (median 6820 μg/L; IQR 6619 μg/L), despite not reaching significant results. We describe trends of all the abovementioned parameters during ICU stay. CONCLUSIONS: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
    Keywords COVID-19 ; Critical care ; Lymphopenia ; Ferritins ; Lymphocytes ; Coagulation ; Immunity ; Iron ; SARS-CoV-2 ; Coronavirus ; MeSH repository (3-10) ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  6. Article ; Online: Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients

    Giuliano Bolondi / Emanuele Russo / Emiliano Gamberini / Alessandro Circelli / Manlio Cosimo Claudio Meca / Etrusca Brogi / Lorenzo Viola / Luca Bissoni / Venerino Poletti / Vanni Agnoletti

    World Journal of Emergency Surgery, Vol 15, Iss 1, Pp 1-

    an observational cohort study

    2020  Volume 8

    Abstract: ... metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided ... soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 ... Abstract Background Iron metabolism and immune response to SARS-CoV-2 have not been described ...

    Abstract Abstract Background Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. Methods We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann–Whitney test. Trends over time were tested with the Kruskal–Wallis analysis. Results Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 109/L; interquartile range (IQR) 0.450 109/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither ferritin nor lymphocyte count follows significant trends in ICU patients. Transferrin saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at days 3 to 6 (median 33%, IQR 26.5%, p value 0.026). The same trend is observed with serum iron levels (median 25.5 μg/L, IQR 69 μg/L at admission; median 73 μg/L, IQR 56 μg/L on days 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing haemophagocytic lymphohistiocytosis. D-dimer is elevated and progressively increases from admission (median 1319 μg/L; IQR 1285 μg/L) to days 3 to 6 (median 6820 μg/L; IQR 6619 μg/L), despite not reaching significant results. We describe trends of all the abovementioned parameters during ICU stay. Conclusions The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
    Keywords MeSH repository (3-10) ; Iron ; COVID-19 ; SARS-CoV-2 ; Coronavirus ; Critical care ; Surgery ; RD1-811 ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  7. Article: Iron metabolism and lymphocyte characterisation during Covid-19 infection in ICU patients: an observational cohort study

    Bolondi, Giuliano

    World journal of emergency surgery, 15(1):41

    2020  

    Abstract: ... metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided ... soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 ... BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described ...

    Abstract BACKGROUND: Iron metabolism and immune response to SARS-CoV-2 have not been described yet in intensive care patients, although they are likely involved in Covid-19 pathogenesis. METHODS: We performed an observational study during the peak of pandemic in our intensive care unit, dosing D-dimer, C-reactive protein, troponin T, lactate dehydrogenase, ferritin, serum iron, transferrin, transferrin saturation, transferrin soluble receptor, lymphocyte count and NK, CD3, CD4, CD8 and B subgroups of 31 patients during the first 2 weeks of their ICU stay. Correlation with mortality and severity at the time of admission was tested with the Spearman coefficient and Mann–Whitney test. Trends over time were tested with the Kruskal–Wallis analysis. RESULTS: Lymphopenia is severe and constant, with a nadir on day 2 of ICU stay (median 0.555 109/L; interquartile range (IQR) 0.450 109/L); all lymphocytic subgroups are dramatically reduced in critically ill patients, while CD4/CD8 ratio remains normal. Neither ferritin nor lymphocyte count follows significant trends in ICU patients. Transferrin saturation is extremely reduced at ICU admission (median 9%; IQR 7%), then significantly increases at days 3 to 6 (median 33%, IQR 26.5%, p value 0.026). The same trend is observed with serum iron levels (median 25.5 μg/L, IQR 69 μg/L at admission; median 73 μg/L, IQR 56 μg/L on days 3 to 6) without reaching statistical significance. Hyperferritinemia is constant during intensive care stay: however, its dosage might be helpful in individuating patients developing haemophagocytic lymphohistiocytosis. D-dimer is elevated and progressively increases from admission (median 1319 μg/L; IQR 1285 μg/L) to days 3 to 6 (median 6820 μg/L; IQR 6619 μg/L), despite not reaching significant results. We describe trends of all the abovementioned parameters during ICU stay. CONCLUSIONS: The description of iron metabolism and lymphocyte count in Covid-19 patients admitted to the intensive care unit provided with this paper might allow a wider understanding of SARS-CoV-2 pathophysiology.
    Keywords COVID-19 ; Iron ; Lymphopenia ; Coagulation ; Coronavirus ; Critical care ; Ferritins ; Immunity ; Lymphocytes ; MeSH repository (3-10) ; SARS-CoV-2
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

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