Article ; Online: Disentangling conflicting evidence on DPP-4 inhibitors and outcomes of COVID-19: narrative review and meta-analysis.
Journal of endocrinological investigation
2021 Volume 44, Issue 7, Page(s) 1379–1386
Abstract: ... on COVID-19-related outcomes in people with DM. For this purpose, we conducted a systematic review and ... provide inconsistent results on the association between use of DPP4i and outcomes of COVID-19. While two ... inhibitors (DPP4i) may play a role against COVID-19.: Methods: We focused on the impact of DPP4i treatment ...
| Abstract | Background: The infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread all over the world, becoming pandemic. Several studies have shown that diabetes mellitus (DM) is an independent risk factor that increases mortality and other adverse outcomes of coronavirus disease-19 (COVID-19). Studies have suggested that SARS-CoV-2 may bind dipeptidyl peptidase-4 (DPP4) for entering cells of the respiratory tract. Besides, DPP4 takes part in immune system regulation. Thus, DPP-4 inhibitors (DPP4i) may play a role against COVID-19. Methods: We focused on the impact of DPP4i treatment on COVID-19-related outcomes in people with DM. For this purpose, we conducted a systematic review and meta-analysis to summarize the existing evidence on this topic. Results: Retrospective observational studies provide inconsistent results on the association between use of DPP4i and outcomes of COVID-19. While two studies reported significantly lower mortality rates among patients with DM who received DPP4i versus those who did not, a series of other studies showed no effect of DPP4i or even worse outcomes. A meta-analysis of 7 studies yielded a neutral estimate of the risk ratio of COVID-19-related mortality among users of DPP4i (0.81; 95% CI 0.57-1.15). Conclusion: In the absence of randomized controlled trials, observational research available so far provides inconclusive results and insufficient evidence to recommend use of DPP4i against COVID-19. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Dipeptidyl Peptidase 4/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Humans ; SARS-CoV-2/metabolism ; Treatment Outcome ; COVID-19 Drug Treatment | |||||
| Chemical Substances | Dipeptidyl-Peptidase IV Inhibitors ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) | |||||
| Language | English | |||||
| Publishing date | 2021-01-29 | |||||
| Publishing country | Italy | |||||
| Document type | Journal Article ; Meta-Analysis ; Systematic Review | |||||
| ZDB-ID | 432272-1 | |||||
| ISSN | 1720-8386 ; 0391-4097 ; 1121-1369 | |||||
| ISSN (online) | 1720-8386 | |||||
| ISSN | 0391-4097 ; 1121-1369 | |||||
| DOI | 10.1007/s40618-021-01515-6 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1480: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.