Article ; Online: Using mixed-effects modeling to estimate decay kinetics of response to SARS-CoV-2 infection.
Antibody therapeutics
2021 Volume 4, Issue 3, Page(s) 144–148
Abstract: ... publication characterizing SARS-CoV-2 immunity over time, the authors fit pooled longitudinal data, using ... illustrates the utility of mixed-effects modeling in provide more accurate estimates of the duration and ... SARS-CoV-2) is a matter of some debate in the literature at present. For example, in a recent ...
| Abstract | The duration of natural immunity in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a matter of some debate in the literature at present. For example, in a recent publication characterizing SARS-CoV-2 immunity over time, the authors fit pooled longitudinal data, using fitted slopes to infer the duration of SARS-CoV-2 immunity. In fact, such approaches can lead to misleading conclusions as a result of statistical model-fitting artifacts. To exemplify this phenomenon, we reanalyzed one of the markers (pseudovirus neutralizing titer) in the publication, using mixed-effects modeling, a methodology better suited to longitudinal datasets like these. Our findings showed that the half-life was both longer and more variable than reported by the authors. The example selected by us here illustrates the utility of mixed-effects modeling in provide more accurate estimates of the duration and heterogeneity of half-lives of molecular and cellular biomarkers of SARS-CoV-2 immunity. |
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| Language | English |
| Publishing date | 2021-06-25 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2516-4236 |
| ISSN (online) | 2516-4236 |
| DOI | 10.1093/abt/tbab013 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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