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  1. Article ; Online: SARS-Cov-2 Damage on the Nervous System and Mental Health.

    Boulkrane, Mohamed Said / Ilina, Victoria / Melchakov, Roman / Arisov, Mikhail / Fedotova, Julia / Gozzo, Lucia / Drago, Filippo / Lu, Weihong / Sarapultsev, Alexey / Tseilikman, Vadim / Baranenko, Denis

    Current neuropharmacology

    2021  Volume 20, Issue 2, Page(s) 412–431

    Abstract: ... on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders ... symptoms, several reports have documented various neurological symptoms and impairments of mental health ... The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection ...

    Abstract The World Health Organization declared the pandemic situation caused by SARSCoV- 2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mildmoderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.
    MeSH term(s) COVID-19 ; Humans ; Mental Health ; Nervous System Diseases/etiology ; SARS-CoV-2
    Language English
    Publishing date 2021-07-06
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X19666210629151303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Autoimmune limbic encephalitis related to SARS-CoV-2 infection: Case-report and review of the literature.

    Pizzanelli, Chiara / Milano, Chiara / Canovetti, Silvia / Tagliaferri, Enrico / Turco, Francesco / Verdenelli, Stefano / Nesti, Lorenzo / Franchi, Marta / Bonanni, Enrica / Menichetti, Francesco / Volterrani, Duccio / Cosottini, Mirco / Siciliano, Gabriele

    Brain, behavior, & immunity - health

    2021  Volume 12, Page(s) 100210

    Abstract: Background: SARS-CoV-2 infection is associated with a wide spectrum of neurological complications ... in COVID-19 patients and to consider the possibility of an autoimmune LE, in particular when altered mental ... including encephalitis. Most cases showed features consistent with a central nervous system (CNS) cytokine ...

    Abstract Background: SARS-CoV-2 infection is associated with a wide spectrum of neurological complications, including encephalitis. Most cases showed features consistent with a central nervous system (CNS) cytokine-mediated damage. However, few cases arguing for an autoimmune mechanism have been described, mainly as single reports or sparse in large case series involving other CNS manifestations. In this paper, we described a case of definite autoimmune limbic encephalitis (LE) COVID-19 related and reviewed the existing literature on other reported cases.
    Case report: Two weeks after the onset of COVID-19 infection, a 74-year-old woman presented with subacute confusion and focal motor seizures with impaired awareness, starting from left temporal region. Cerebrospinal fluid analysis revealed hyperproteinorrachia. Brain MRI showed bilateral T2/FLAIR hyperintensities in both hippocampi and total body PET/TC scan revealed hypermetabolism in basal ganglia bilaterally. A diagnosis of autoimmune LE was made. Thus, high dose corticosteroids and antiseizure medications were started, with a marked improvement of neurological conditions.
    Literature review: We systematically reviewed the literature to identify all well-documented cases of definite autoimmune LE (according to Graus criteria) in patients with COVID-19 infection, identifying other five cases exhibiting a good response to immunomodulating therapy.
    Conclusion: A very limited number of autoimmune LE have been described until now. It is important to monitor neurological symptoms in COVID-19 patients and to consider the possibility of an autoimmune LE, in particular when altered mental status and seizures appear late in the disease course. This allows to promptly start the appropriate treatments and avoid unnecessary delays.
    Language English
    Publishing date 2021-01-24
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2021.100210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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