Article ; Online: Is Alcohol in Hand Sanitizers Absorbed Through the Skin or Lungs? Implications for Disulfiram Treatment.
Alcohol and alcoholism (Oxford, Oxfordshire)
2020 Volume 55, Issue 4, Page(s) 354–356
Abstract: ... about absorption of alcohol through the skin from hand sanitizers and products such as perfumes, deodorants and ... to the cutaneous absorption of alcohol from hand sanitizers as well as by inhalation of vapour.: Method: Simple ... suggest that while amounts of alcohol sufficient to cause a DER may be inhaled when hand sanitizers are ...
| Abstract | Aim: In view of the increase in the use of ethanol-containing hand sanitizers throughout the world due to the current COVID-19 pandemic, we wished to review the possible risks to patients treated with disulfiram, following a case report in which an apparent DER (disulfiram-ethanol reaction) was attributed to the cutaneous absorption of alcohol from hand sanitizers as well as by inhalation of vapour. Method: Simple experiments to assess the levels of absorption by each route separately. Results: Our results strongly suggest that while amounts of alcohol sufficient to cause a DER may be inhaled when hand sanitizers are used in confined spaces, absorption can be avoided by dispersal of the fumes, and absorption from the skin alone does not occur in pharmacologically significant quantities. Conclusion: Warnings about absorption of alcohol through the skin from hand sanitizers and products such as perfumes, deodorants and after-shave (whose use is often warned against when disulfiram is prescribed) should be modified accordingly. |
|---|---|
| MeSH term(s) | Administration, Inhalation ; Betacoronavirus ; Breath Tests/methods ; COVID-19 ; Coronavirus Infections/complications ; Disulfiram/adverse effects ; Disulfiram/chemistry ; Disulfiram/pharmacokinetics ; Disulfiram/therapeutic use ; Ethanol/administration & dosage ; Ethanol/adverse effects ; Ethanol/chemistry ; Ethanol/pharmacokinetics ; Hand Sanitizers/administration & dosage ; Hand Sanitizers/adverse effects ; Hand Sanitizers/chemistry ; Hand Sanitizers/pharmacokinetics ; Humans ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Skin Absorption/drug effects |
| Chemical Substances | Hand Sanitizers ; Ethanol (3K9958V90M) ; Disulfiram (TR3MLJ1UAI) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-11 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 604956-4 |
| ISSN | 1464-3502 ; 0309-1635 ; 0735-0414 |
| ISSN (online) | 1464-3502 |
| ISSN | 0309-1635 ; 0735-0414 |
| DOI | 10.1093/alcalc/agaa045 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.B 798: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.