Article: PHLiPPing the switch on Akt and protein kinase C signaling.
Trends in endocrinology and metabolism: TEM
2008 Volume 19, Issue 6, Page(s) 223–230
Abstract: ... phosphatase] provides 'the brakes' for Akt and protein kinase C (PKC) signaling. The two isoforms ... of this recently discovered family, PHLPP1 and PHLPP2, control the amplitude and duration of signaling of Akt and ... the degree of agonist-evoked signaling by Akt and the cellular levels of PKC. This review focuses ...
| Abstract | The Ser/Thr-specific phosphatase PHLPP [pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase] provides 'the brakes' for Akt and protein kinase C (PKC) signaling. The two isoforms of this recently discovered family, PHLPP1 and PHLPP2, control the amplitude and duration of signaling of Akt and PKC by catalyzing the dephosphorylation of the hydrophobic phosphorylation motif, a C-terminal phosphorylation switch that controls these kinases. Aberrant regulation of either kinase accompanies many diseases, notably diabetes and cancer. By specifically dephosphorylating the hydrophobic motif, PHLPP controls the degree of agonist-evoked signaling by Akt and the cellular levels of PKC. This review focuses on the function of PHLPP1 and PHLPP2 in modulating signaling by Akt and PKC. |
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| MeSH term(s) | Binding Sites ; Humans ; Models, Biological ; Nuclear Proteins/classification ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Phosphoprotein Phosphatases ; Phylogeny ; Protein Kinase C/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction | |||||
| Chemical Substances | Nuclear Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Protein Kinase C (EC 2.7.11.13) ; PHLPP1 protein, human (EC 3.1.3.16) ; Phosphoprotein Phosphatases (EC 3.1.3.16) | |||||
| Language | English | |||||
| Publishing date | 2008-05-27 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review | |||||
| ZDB-ID | 1042384-9 | |||||
| ISSN | 1879-3061 ; 1043-2760 | |||||
| ISSN (online) | 1879-3061 | |||||
| ISSN | 1043-2760 | |||||
| DOI | 10.1016/j.tem.2008.04.001 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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