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  1. Article: Early Diagnosis and Treatment of Pyoderma Gangrenosum: Reviewing Mobile Phone Photos Saved a Patient From Unnecessary Surgeries.

    Keramidas, Evangelos / Rodopoulou, Stavroula / Avgerinos, Nikolaos

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54797

    Abstract: ... the adjacent skin. The greatest issue concerning pyoderma gangrenosum is its diagnosis. Almost invariably ... Pyoderma gangrenosum of the breast following surgery is a rare aseptic inflammatory cutaneous ... We present a rare case report of pyoderma gangrenosum complicating the surgical site of the breast reduction ...

    Abstract Pyoderma gangrenosum of the breast following surgery is a rare aseptic inflammatory cutaneous condition that causes very rapid progressing and expanding painful ulceration of the surgical site and the adjacent skin. The greatest issue concerning pyoderma gangrenosum is its diagnosis. Almost invariably, it is misdiagnosed as a wound infection, which results in delayed identification, lengthy antibiotic regimens, and ineffective detrimental surgical debridements, causing significant patient disfigurement. We present a rare case report of pyoderma gangrenosum complicating the surgical site of the breast reduction procedure two months after simultaneous performance of operations including breast reduction, abdominoplasty, and lumbar liposuction. The diagnosis was established within four hours from the initial lesion and symptom presentation due to the accurate evaluation of photographs sent from the patient's mobile phone to the surgeon every half hour. Immediate appropriate treatment with oral corticosteroids within this time interval was initiated, resulting in favorable healing for the patient within four months.
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diagnosis and treatment of pyoderma gangrenosum.

    Brooklyn, Trevor / Dunnill, Giles / Probert, Chris

    BMJ (Clinical research ed.)

    2006  Volume 333, Issue 7560, Page(s) 181–184

    MeSH term(s) Biopsy ; Early Diagnosis ; Humans ; Immunosuppressive Agents/therapeutic use ; Pyoderma Gangrenosum/pathology ; Pyoderma Gangrenosum/therapy ; Skin/pathology
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2006-07-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.333.7560.181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Case study: diagnosis and treatment of pyoderma gangrenosum.

    Burton, Julie

    British journal of nursing (Mark Allen Publishing)

    2005  Volume 14, Issue 16, Page(s) S10–3

    Abstract: ... of stoma care with inflammatory bowel disease (IBD) (Lyon and Smith, 2001). Pyoderma gangrenosum is ... Pyoderma gangrenosum, is an ulcerative, inflammatory disorder often associated in the field ... of Pyoderma gangrenosum. It also explores the possible causes of this particular manifestation. ...

    Abstract Pyoderma gangrenosum, is an ulcerative, inflammatory disorder often associated in the field of stoma care with inflammatory bowel disease (IBD) (Lyon and Smith, 2001). Pyoderma gangrenosum is distinctive in that it normally has a purple rolled edge and is extremely painful. The pathogenesis is unknown but immunologic aberrations of neutrophil granulocytes seem to be important (Petering et al, 2001). This paper demonstrates the rapid development and effective multi-disciplinary team management of an extensive case of Pyoderma gangrenosum. It also explores the possible causes of this particular manifestation.
    MeSH term(s) Colostomy/adverse effects ; Combined Modality Therapy ; Debridement ; Humans ; Inflammatory Bowel Diseases/complications ; Male ; Middle Aged ; Pyoderma Gangrenosum/complications ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/therapy ; Treatment Outcome ; Wound Healing
    Language English
    Publishing date 2005-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2005.14.Sup4.19736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3449: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Diagnosis and Treatment Difficulty in Early-Onset Peristomal Pyoderma Gangrenosum Associated With Ulcerative Colitis: A Case Report.

    Imaizumi, Ken / Kasajima, Hiroyuki / Terashima, Kazutoshi / Furukawa, Naoe / Nakanishi, Kazuaki

    Cureus

    2022  Volume 14, Issue 2, Page(s) e22405

    Abstract: Peristomal pyoderma gangrenosum (PPG) is a rare dermatological condition associated ... an essential role in its diagnosis and management. ... with gastroenterological disease. Most gastrointestinal surgeons find it difficult to suspect and treat PPG, especially ...

    Abstract Peristomal pyoderma gangrenosum (PPG) is a rare dermatological condition associated with gastroenterological disease. Most gastrointestinal surgeons find it difficult to suspect and treat PPG, especially at early onset. The patient was an 18-year-old female. The patient underwent three-stage restorative proctocolectomy for refractory ulcerative colitis. On postoperative day (POD) 9, the trocar wound near the ileostomy site dehisced. Because the wound culture was positive, the wound was treated with an antibacterial agent as an infection. However, the wound worsened. The patient was referred to a dermatologist for diagnosis. PPG was diagnosed on POD 37. Wound management was initiated using topical steroids. The wound caused difficulties in pain and dressing management. Although infliximab was administered as a systemic therapy, it was discontinued because of allergic symptoms. Sealing therapy with hydrofiber dressing and adequate stoma pouching with stoma paste provided good exudate absorption and a clean environment by protecting the wound from stoma excretion. Oral prednisone was initiated on POD 82. Improvement in the wound condition was observed with a prednisone dose of 30 mg/day. Complete remission was achieved seven months after onset. Twelve months after the surgery, stoma closure was performed. The local cutaneous condition remained in remission without exacerbation. Suspicion of PPG can be difficult when it develops early after stoma creation. We never forget that PPG should be suspected when a progressive ulcerative lesion is found around the stoma, even early after operation. If PPG is suspected, a multidisciplinary team plays an essential role in its diagnosis and management.
    Language English
    Publishing date 2022-02-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22405
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  5. Article ; Online: Diagnosis and novel clinical treatment strategies for pyoderma gangrenosum.

    Goldust, Mohamad / Hagstrom, Erika L / Rathod, Dipali / Ortega-Loayza, Alex G

    Expert review of clinical pharmacology

    2020  Volume 13, Issue 2, Page(s) 157–161

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Adrenal Cortex Hormones/administration & dosage ; Biological Factors/administration & dosage ; Dermatologic Agents/administration & dosage ; Disease Progression ; Humans ; Immunosuppressive Agents/administration & dosage ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/drug therapy ; Pyoderma Gangrenosum/pathology ; Severity of Illness Index
    Chemical Substances Adrenal Cortex Hormones ; Biological Factors ; Dermatologic Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2020.1709825
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  6. Article: A case of extracutaneous pyoderma gangrenosum in a patient with persistent cutaneous and systemic symptoms: Implications for differential diagnosis and treatment.

    Santa Lucia, Gabriella / DeMaio, Alexa / Karlin, Samantha / Elston, Dirk

    JAAD case reports

    2021  Volume 15, Page(s) 85–87

    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2021.07.019
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  7. Article ; Online: Pyoderma gangrenosum after deep inferior epigastric perforator flap: How prompt diagnosis and treatment can avoid surgical debridement and further morbidity.

    Bombardelli, Joao / Parikh, Janak / Morkuzu, Suat / Spiegel, Aldona J

    JPRAS open

    2022  Volume 33, Page(s) 42–46

    Abstract: ... with steroids with appropriate response. Our case highlights the importance of rapid diagnosis and treatment ... Pyoderma gangrenosum (PG) is a skin disorder characterized by painful, enlarging necrotic ulcers ... Crohn's disease, the diagnosis is commonly missed at presentation and patients are often treated for infection ...

    Abstract Pyoderma gangrenosum (PG) is a skin disorder characterized by painful, enlarging necrotic ulcers with bluish borders surrounded by advancing zones of erythema. The key histologic feature is neutrophilic infiltration of the superficial and deep layers of the dermis and the absence of microorganisms. Although rare and associated with autoimmune diseases such as rheumatoid arthritis, ulcerative colitis and Crohn's disease, the diagnosis is commonly missed at presentation and patients are often treated for infection with antibiotics and surgical debridement. We present a case of PG in a 51 year-old woman after a deep inferior epigastric perforator (DIEP) flap for breast reconstruction who was promptly diagnosed and treated with steroids with appropriate response. Our case highlights the importance of rapid diagnosis and treatment of this disease to avoid incorrect management including surgical debridement, which can exacerbate the disease and increase its morbidity.
    Language English
    Publishing date 2022-05-16
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2834721-3
    ISSN 2352-5878 ; 2352-5878
    ISSN (online) 2352-5878
    ISSN 2352-5878
    DOI 10.1016/j.jpra.2022.05.009
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  8. Article ; Online: Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment.

    Alavi, Afsaneh / French, Lars E / Davis, Mark D / Brassard, Alain / Kirsner, Robert S

    American journal of clinical dermatology

    2017  Volume 18, Issue 3, Page(s) 355–372

    Abstract: Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic disorder with prototypical clinical ... disease, cost, and side effects of treatment, as well as patient comorbidities and preferences. Refractory and ... therapeutic targets. PG equally affects patients of both sexes and of any age. Uncontrolled cutaneous ...

    Abstract Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic disorder with prototypical clinical presentations. Its pathophysiology is complex and not fully explained. Recent information regarding the genetic basis of PG and the role of auto-inflammation provides a better understanding of the disease and new therapeutic targets. PG equally affects patients of both sexes and of any age. Uncontrolled cutaneous neutrophilic inflammation is the cornerstone in a genetically predisposed individual. Multimodality management is often required to reduce inflammation, optimize wound healing, and treat underlying disease. A gold standard for the management of PG does not exist and high-level evidence is limited. Multiple factors must be taken into account when deciding on the optimum treatment for individual patients: location, number and size of lesion/ulceration(s), extracutaneous involvement, presence of associated disease, cost, and side effects of treatment, as well as patient comorbidities and preferences. Refractory and rapidly progressive cases require early initiation of systemic therapy. Newer targeted therapies represent a promising pathway for the management of PG, and the main focus of this review is the management and evidence supporting the role of new targeted therapies in PG.
    Language English
    Publishing date 2017-06
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1502476-3
    ISSN 1179-1888 ; 1175-0561
    ISSN (online) 1179-1888
    ISSN 1175-0561
    DOI 10.1007/s40257-017-0251-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5639: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Postsurgical Pyoderma Gangrenosum After Breast Surgery: A Plea for Early Suspicion, Diagnosis, and Treatment.

    Hammond, Dennis / Chaudhry, Arif / Anderson, Daniella / Alameddine, Khaled O / Tajran, Jahan

    Aesthetic plastic surgery

    2020  Volume 44, Issue 6, Page(s) 2032–2040

    Abstract: ... diagnosis, course of treatment, and results were documented. The PubMed database was then searched to find ... Background: Pyoderma gangrenosum (PG) is a rare inflammatory cutaneous disorder. Although PG is ... surgery procedures to the breast. Early recognition and treatment can facilitate prompt reversal ...

    Abstract Background: Pyoderma gangrenosum (PG) is a rare inflammatory cutaneous disorder. Although PG is a diagnosis of exclusion, prompt recognition is essential to attain the desired outcomes. From an aesthetic standpoint, this is especially critical with breast involvement and other body segments. We present a consecutive case series of four patients who developed PG following breast surgery and responded to early intervention.
    Methods: A chart review identified four patients who were identified as having developed PG after either aesthetic or reconstructive breast surgery. Their histories, associated risk factors, diagnosis, course of treatment, and results were documented. The PubMed database was then searched to find the literature for comparison.
    Results: The average time from surgery to the onset of symptoms was 11 days, and the average time from the onset of symptoms to the correct diagnosis of PG was 41 days. The average length of steroid therapy was 25 days. The average time from the initiation of steroids to complete wound closure was 51 days. The average time from the onset of symptoms to complete wound closure bilaterally was 87 days. All wounds healed with conservative management.
    Conclusion: Postsurgical PG is a rare but recognized cause of postoperative wound breakdown in patients who have undergone plastic surgery procedures to the breast. Early recognition and treatment can facilitate prompt reversal of the inflammatory process leading to complete wound healing and limitation of the morbidity that can be associated with the disease.
    Level of evidence v: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    MeSH term(s) Breast Neoplasms ; Humans ; Mammaplasty/adverse effects ; Mastectomy/adverse effects ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/drug therapy ; Pyoderma Gangrenosum/etiology ; Reconstructive Surgical Procedures ; Wound Healing
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 532791-x
    ISSN 1432-5241 ; 0364-216X
    ISSN (online) 1432-5241
    ISSN 0364-216X
    DOI 10.1007/s00266-020-01899-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1296: Show issues Location:
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  10. Article ; Online: Oral Pyoderma Gangrenosum: Diagnosis, Treatment and Challenges: A Systematic Review.

    Bissonnette, Caroline / Kauzman, Adel / Mainville, Gisele N

    Head and neck pathology

    2017  Volume 11, Issue 4, Page(s) 427–441

    Abstract: Pyoderma gangrenosum (PG) is a distinctive ulcerative skin disorder of unknown etiology, associated ... activities such as mastication and oral hygiene, as well as during dental treatment, oral lesions appear ... diagnostic criteria and to discuss the differential diagnosis and therapeutic modalities. ...

    Abstract Pyoderma gangrenosum (PG) is a distinctive ulcerative skin disorder of unknown etiology, associated with an underlying systemic disease in up to 70% of cases. The condition is characterized by the appearance of one or more necrotic ulcers with a ragged undermined violaceous border and surrounding erythema. Lesions are often initiated by minor trauma. The condition can affect any anatomical site, however the head and neck are rarely involved. Although the oral cavity is subject to recurrent minor trauma through everyday activities such as mastication and oral hygiene, as well as during dental treatment, oral lesions appear to be extremely rare. In an effort to provide a detailed explanation of the oral manifestations of PG, a systematic search was conducted using medical databases. A total of 20 cases of PG with oral involvement were reported in the English and French literature. The objectives of this article are to present the pertinent diagnostic criteria and to discuss the differential diagnosis and therapeutic modalities.
    MeSH term(s) Diagnosis, Differential ; Humans ; Oral Ulcer/diagnosis ; Oral Ulcer/etiology ; Oral Ulcer/therapy ; Pyoderma Gangrenosum/complications ; Pyoderma Gangrenosum/diagnosis ; Pyoderma Gangrenosum/therapy
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-017-0804-3
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