Article ; Online: Cell-type identity: a key to unlocking the function of neocortical circuits.
Current opinion in neurobiology
2009 Volume 19, Issue 4, Page(s) 415–421
Abstract: ... type is key when analyzing neocortical circuits. Furthermore, identifying the circuit organization ... circuits. These studies indicate that knowing the identity of both the presynaptic and postsynaptic cell ... of local circuits has been challenging. Here, we review recent work in sensory neocortex that demonstrates ...
| Abstract | A central tenet of neuroscience is that the precise patterns of connectivity among neurons in a given brain area underlie its function. However, assigning any aspect of perception or behavior to the wiring of local circuits has been challenging. Here, we review recent work in sensory neocortex that demonstrates the power of identifying specific cell types when investigating the functional organization of brain circuits. These studies indicate that knowing the identity of both the presynaptic and postsynaptic cell type is key when analyzing neocortical circuits. Furthermore, identifying the circuit organization of particular cell types in the neocortex allows the recording and manipulation of each cell type's activity and the direct testing of its functional role in perception and behavior. |
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| MeSH term(s) | Animals ; Nerve Net/physiology ; Neural Inhibition/physiology ; Neurons/physiology ; Somatosensory Cortex/physiology ; Synapses/physiology ; Synaptic Transmission/physiology | |||||
| Language | English | |||||
| Publishing date | 2009-08-10 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 1078046-4 | |||||
| ISSN | 1873-6882 ; 0959-4388 | |||||
| ISSN (online) | 1873-6882 | |||||
| ISSN | 0959-4388 | |||||
| DOI | 10.1016/j.conb.2009.07.011 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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