Article ; Online: Predictive values, uncertainty, and interpretation of serology tests for the novel coronavirus.
2021 Volume 11, Issue 1, Page(s) 5491
Abstract: ... interpretations, and plots of positive and negative predictive values under a variety of scenarios. Prevalence ... Specifically, the proportion of positive serology tests that are false can differ drastically from up to 3%-88 ... sensitivity, and specificity are estimated within ranges of values from researchers and antibodies manufacturers. Illustrative ...
| Abstract | Antibodies testing in the coronavirus era is frequently promoted, but the underlying statistics behind their validation has come under more scrutiny in recent weeks. We provide calculations, interpretations, and plots of positive and negative predictive values under a variety of scenarios. Prevalence, sensitivity, and specificity are estimated within ranges of values from researchers and antibodies manufacturers. Illustrative examples are highlighted, and interactive plots are provided in the Supplementary Information. Implications are discussed for society overall and across diverse locations with different levels of disease burden. Specifically, the proportion of positive serology tests that are false can differ drastically from up to 3%-88% for people from different places with different proportions of infected people in the populations while the false negative rate is typically under 10%. |
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| MeSH term(s) | Antibodies, Viral/blood ; COVID-19/diagnosis ; COVID-19/virology ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Humans ; Predictive Value of Tests ; Reagent Kits, Diagnostic ; SARS-CoV-2/isolation & purification ; Serologic Tests/methods ; Uncertainty |
| Chemical Substances | Antibodies, Viral ; Reagent Kits, Diagnostic |
| Language | English |
| Publishing date | 2021-03-09 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-84173-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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