Article ; Online: Ischemic Lesions in the Brain of a Neonate With SARS-CoV-2 Infection.
The Pediatric infectious disease journal
2021 Volume 40, Issue 9, Page(s) e340–e343
Abstract: ... SARS-CoV-2) infection and multisystem involvement including seizures associated to ischemic lesions ... Conclusions: SARS-CoV-2 neonatal infection can be associated with multi-organic involvement. In our patient ... in whom consumption coagulopathy, ischemic lesions in the brain and cardiac involvement were documented ...
| Abstract | Aim: To describe a term newborn with acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and multisystem involvement including seizures associated to ischemic lesions in the brain. Background: Coronavirus disease 2019 (COVID-19) is predominantly a respiratory infection, but it may affect many other systems. Most pediatric COVID-19 cases range from asymptomatic to mild-moderate disease. There are no specific clinical signs described for neonatal COVID-19 infections. In children, severe central nervous system compromise has been rarely reported. Case description: We describe a 17-day-old newborn who acquired a SARS-CoV-2 infection in a family meeting that was admitted for fever, seizures and lethargy and in whom consumption coagulopathy, ischemic lesions in the brain and cardiac involvement were documented. Conclusions: SARS-CoV-2 neonatal infection can be associated with multi-organic involvement. In our patient, significant central nervous system compromise associated to ischemic lesions and laboratory findings of consumption coagulopathy were found. Clinical significance: Although neonatal SARS-CoV-2 infections are infrequent, they can be associated with multi-organic involvement. Neonatologists and pediatricians should be aware of this unusual way of presentation of COVID-19 in newborn infants. |
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| MeSH term(s) | Acyclovir/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Brain/diagnostic imaging ; Brain Ischemia/pathology ; Brain Ischemia/virology ; COVID-19/complications ; COVID-19/pathology ; Ceftriaxone/therapeutic use ; Fever ; Frontal Lobe/blood supply ; Frontal Lobe/diagnostic imaging ; Frontal Lobe/pathology ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/drug therapy ; Infant, Newborn, Diseases/pathology ; Infant, Newborn, Diseases/virology ; Lethargy ; Magnetic Resonance Imaging ; Male ; Nasopharynx/virology ; SARS-CoV-2/isolation & purification ; Seizures ; COVID-19 Drug Treatment | |||||
| Chemical Substances | Anti-Bacterial Agents ; Antiviral Agents ; Ceftriaxone (75J73V1629) ; Acyclovir (X4HES1O11F) | |||||
| Language | English | |||||
| Publishing date | 2021-07-14 | |||||
| Publishing country | United States | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 392481-6 | |||||
| ISSN | 1532-0987 ; 0891-3668 | |||||
| ISSN (online) | 1532-0987 | |||||
| ISSN | 0891-3668 | |||||
| DOI | 10.1097/INF.0000000000003244 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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