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  1. Article ; Online: Dermatologic manifestations of COVID-19-associated multisystem inflammatory syndrome in children.

    Brumfiel, Caitlin M / DiLorenzo, Ashley M / Petronic-Rosic, Vesna M

    Clinics in dermatology

    2020  Volume 39, Issue 2, Page(s) 329–333

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) affects a small percentage of pediatric ... we identified cutaneous manifestations documented in 417 of 736 patients (57%) with MIS-C associated with COVID ... patients infected with COVID-19 and is characterized by fever, laboratory evidence of inflammation ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) affects a small percentage of pediatric patients infected with COVID-19 and is characterized by fever, laboratory evidence of inflammation, multisystem involvement, and severe illness necessitating hospitalization. Skin findings are often present in these patients, and when initially compared with Kawasaki disease, they likely represent distinct phenomena and overall remain poorly characterized. In this retrospective review of 34 case reports and series, we identified cutaneous manifestations documented in 417 of 736 patients (57%) with MIS-C associated with COVID-19. "Rash" was the sole descriptor of skin findings in nearly half of patients. Case reports and smaller case series provided more detail, outlining a broad range of lesion morphologies (polymorphic, maculopapular, morbilliform, erythrodermic, urticarial, reticular, petechial, purpuric) in variable anatomic distribution. More thorough descriptions of dermatologic manifestations in patients with MIS-C are warranted to better characterize this syndrome, as they may lend important insight into pathogenic mechanisms of disease.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; Child ; Humans ; Retrospective Studies ; Skin Diseases/etiology ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/diagnosis
    Language English
    Publishing date 2020-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2020.10.021
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  2. Article ; Online: Dermatologic manifestations of COVID-19-associated multisystem inflammatory syndrome in children

    Brumfiel, Caitlin M. / DiLorenzo, Ashley M. / Petronic-Rosic, Vesna M.

    Clinics in Dermatology ; ISSN 0738-081X

    2020  

    Keywords Dermatology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.clindermatol.2020.10.021
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Dermatologic manifestations of COVID-19-associated multisystem inflammatory syndrome in children

    Brumfiel, Caitlin M. / DiLorenzo, Ashley M. / Petronic-Rosic, Vesna M.

    Clinics in Dermatology

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) affects a small percentage of pediatric ... cutaneous manifestations documented in 417 of 736 patients (57%) with MIS-C associated with COVID-19 “Rash ... patients infected with COVID-19 and is characterized by fever, laboratory evidence of inflammation ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) affects a small percentage of pediatric patients infected with COVID-19 and is characterized by fever, laboratory evidence of inflammation, multisystem involvement, and severe illness necessitating hospitalization Skin findings are often present in these patients and while initially compared to Kawasaki disease, likely represent distinct phenomena and overall remain poorly characterized In this retrospective review of 34 case reports and series, we identified cutaneous manifestations documented in 417 of 736 patients (57%) with MIS-C associated with COVID-19 “Rash” was the sole descriptor of skin findings in nearly half of patients Case reports and smaller case series provided more detail, outlining a broad range of lesion morphologies (polymorphic, maculopapular, morbilliform, erythrodermic, urticarial, reticular, petechial, purpuric) in variable anatomic distribution More thorough descriptions of dermatologic manifestations in patients with MIS-C are warranted to better characterize this syndrome, as they may lend important insight into pathogenic mechanisms of disease
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #893691
    Database COVID19

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  4. Article ; Online: Dermatologic manifestations of multisystem inflammatory syndrome in children during the COVID-19 pandemic.

    Baykal Selçuk, Leyla / Ferhatosmanoğlu, Arzu / Gayretli Aydın, Zeynep Gökçe / Aksu Arıca, Deniz / Yeşilbaş, Osman

    Anais brasileiros de dermatologia

    2022  Volume 98, Issue 2, Page(s) 168–175

    Abstract: Objectives: multi-system ınflammatory syndrome in children (MIS-C) is an immune-mediated process ... conducted of 43 children admitted to a tertiary hospitals between January 2021 and January 2022 who met ... Centers for Disease Control and Prevention criteria for MIS-C.: Results: 43 children (25 [58.1%] male ...

    Abstract Objectives: multi-system ınflammatory syndrome in children (MIS-C) is an immune-mediated process that develops after infections like SARS-CoV-2. The authors aimed to reveal the mucocutaneous findings of patients diagnosed with MIS-C at presentation and evaluate the frequency of these mucocutaneous findings and their possible relationship with the severity of the disease.
    Methods: A prospective study was conducted of 43 children admitted to a tertiary hospitals between January 2021 and January 2022 who met Centers for Disease Control and Prevention criteria for MIS-C.
    Results: 43 children (25 [58.1%] male); median age, 7.5 years [range 0.5‒15 years]) met the criteria for MIS-C. The most common symptom was cutaneous rash 81.4%, followed by gastrointestinal symptoms 67.4%, oral mucosal changes 65.1%, and conjunctival hyperemia 58.1%. The most common mucosal finding was fissured lips at 27.9%, diffuse hyperemia of the oral mucosa at 18.6%, and strawberry tongue at 13.9%. Urticaria (48.8%) was the most common type of cutaneous rash in the present study's patients. The most common rash initiation sites were the trunk (32.6%) and the palmoplantar region (20.9%). The presence or absence of mucocutaneous findings was not significantly associated with disease severity.
    Study limitations: The number of patients in the this study was small.
    Conclusions: The present study's prospective analysis detected mucocutaneous symptoms in almost 9 out of 10 patients in children diagnosed with MIS-C. Due to the prospective character of the present research, the authors think that the characteristic features of cutaneous and mucosal lesions the authors obtained will contribute to the literature on the diagnosis and prognosis of MIS-C.
    MeSH term(s) Child ; Humans ; Male ; Infant ; Child, Preschool ; Adolescent ; Female ; COVID-19/complications ; COVID-19/epidemiology ; SARS-CoV-2 ; Prospective Studies ; Pandemics ; Hyperemia ; Systemic Inflammatory Response Syndrome/epidemiology ; Connective Tissue Diseases
    Language English
    Publishing date 2022-11-16
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2022.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A dermatologic perspective on multisystem inflammatory syndrome in children.

    Naka, Fludiona / Melnick, Laura / Gorelik, Mark / Morel, Kimberly D

    Clinics in dermatology

    2020  Volume 39, Issue 1, Page(s) 163–168

    Abstract: ... syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019 (COVID-19 ... As of May 2020, an emerging immune-mediated syndrome mainly affecting children has been detected ... infectious assault, with a delay of several weeks. This syndrome has been termed "multisystem inflammatory ...

    Abstract As of May 2020, an emerging immune-mediated syndrome mainly affecting children has been detected primarily in Europe and the United States. The incidence of this syndrome appears to mirror the initial infectious assault, with a delay of several weeks. This syndrome has been termed "multisystem inflammatory syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019 (COVID-19). The phenotypes of presentation include several characteristic features, including prolonged fever, skin eruption, neck stiffness, and gastrointestinal manifestations with pronounced abdominal pain. Shock and organ dysfunction on presentation are frequent but inconsistent, whereas respiratory distress is typically and notably absent. We have reviewed recently published data aiming to better understand MIS-C, with a focus on its mucocutaneous manifestations.
    MeSH term(s) Adolescent ; COVID-19/complications ; COVID-19/diagnosis ; Child ; Child, Preschool ; Conjunctivitis, Viral/virology ; Diagnosis, Differential ; Humans ; Infant ; Infant, Newborn ; Mouth Diseases/virology ; Mouth Mucosa ; Mucocutaneous Lymph Node Syndrome/diagnosis ; SARS-CoV-2 ; Skin Diseases/virology ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/diagnosis
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2020.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A dermatologic perspective on multisystem inflammatory syndrome in children.

    Naka, Fludiona / Melnick, Laura / Gorelik, Mark / Morel, Kimberly D

    Clinics in dermatology

    2020  Volume 39, Issue 2, Page(s) 337–343

    Abstract: ... syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019 ... As of May 2020, an emerging immune-mediated syndrome primarily affecting children has been detected ... infectious assault with a delay of several weeks. This syndrome has been termed "multisystem inflammatory ...

    Abstract As of May 2020, an emerging immune-mediated syndrome primarily affecting children has been detected primarily in Europe and the United States. The incidence of this syndrome appears to mirror the initial infectious assault with a delay of several weeks. This syndrome has been termed "multisystem inflammatory syndrome in children" (MIS-C) and is observed in association with the coronavirus disease 2019. The phenotypes of presentation include several characteristic features, including prolonged fever, skin eruptions, neck stiffness, and gastrointestinal manifestations with pronounced abdominal pain. Shock and organ dysfunction on presentation are frequent but inconsistent, whereas respiratory distress is typically, and notably, absent. We have reviewed the recent published data aiming to better understand MIS-C, with a focus on its mucocutaneous manifestations.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; Child ; Humans ; Skin Diseases/etiology ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/diagnosis
    Language English
    Publishing date 2020-11-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2020.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Dermatologic Perspective on Multisystem Inflammatory Syndrome in Children()()

    Naka, Fludiona / Melnick, Laura / Gorelik, Mark / Morel, Kimberly D.

    Clin Dermatol

    Abstract: ... syndrome in children (MIS-C), and is observed in association with the coronavirus disease 2019 (COVID-19 ... As of May 2020, an emerging immune-mediated syndrome primarily affecting children has been detected ... infectious assault, with a delay of several weeks. This syndrome has been termed multisystem inflammatory ...

    Abstract As of May 2020, an emerging immune-mediated syndrome primarily affecting children has been detected primarily in Europe and the United States. The incidence of this syndrome appears to mirror the initial infectious assault, with a delay of several weeks. This syndrome has been termed multisystem inflammatory syndrome in children (MIS-C), and is observed in association with the coronavirus disease 2019 (COVID-19). The phenotypes of presentation include several characteristic features, including prolonged fever, eruption, neck stiffness and gastrointestinal manifestations with pronounced abdominal pain. Shock and organ dysfunction on presentation are frequently but inconsistent, while respiratory distress is typically, and notably, absent. We have reviewed recently published data aiming to better understanding MIS-C, with a focus on its mucocutaneous manifestations. • Mucocutaneous manifestations of MIS-C: conjunctivitis, oral mucosal changes, rash. • The rash of MIS-C is typically diffuse and non-specific. • Mucocutaneous manifestations of MIS-C are more common in younger children. • KD and MIS-C differ in mean age of onset, race predilection, and associated symptoms.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/j.clindermatol.2020.09.003
    Database COVID19

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