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  1. Book ; Online ; Thesis: Contribution of High Viral Loads, Detection of Viral Antigen and Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 Infectivity

    Buder, Felix [Verfasser] / Schmidt, Barbara [Akademischer Betreuer] / Salzberger, Bernd [Akademischer Betreuer]

    2023  

    Author's details Felix Buder ; Barbara Schmidt, Bernd Salzberger
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Regensburg
    Publishing place Regensburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Correction to: Contribution of High Viral Loads, Detection of Viral Antigen and Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 Infectivity.

    Buder, Felix / Bauswein, Markus / Magnus, Clara L / Audebert, Franz / Lang, Henriette / Kundel, Christof / Distler, Karin / Reuschel, Edith / Lubnow, Matthias / Müller, Thomas / Lunz, Dirk / Graf, Bernhard / Schmid, Stephan / Müller, Martina / Poeck, Hendrik / Hanses, Frank / Salzberger, Bernd / Peterhoff, David / Wenzel, Jürgen J /
    Schmidt, Barbara / Lampl, Benedikt M J

    The Journal of infectious diseases

    2022  Volume 227, Issue 4, Page(s) 605

    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  3. Article ; Online: Contribution of High Viral Loads, Detection of Viral Antigen and Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 Infectivity.

    Buder, Felix / Bauswein, Markus / Magnus, Clara L / Audebert, Franz / Lang, Henriette / Kundel, Christof / Distler, Karin / Reuschel, Edith / Lubnow, Matthias / Müller, Thomas / Lunz, Dirk / Graf, Bernhard / Schmid, Stephan / Müller, Martina / Poeck, Hendrik / Hanses, Frank / Salzberger, Bernd / Peterhoff, David / Wenzel, Jürgen J /
    Schmidt, Barbara / Lampl, Benedikt M J

    The Journal of infectious diseases

    2021  Volume 225, Issue 2, Page(s) 190–198

    Abstract: ... for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) should be balanced with individual liberties.: Methods: We collected ... for the presence of viral antigen. Symptom onset before 10 days and seroconversion predicted lack of infectivity ... with high viral load and detection of viral antigen and lifting restrictive measures with increasing time ...

    Abstract Background: From a public health perspective, effective containment strategies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) should be balanced with individual liberties.
    Methods: We collected 79 respiratory samples from 59 patients monitored in an outpatient center or in the intensive care unit of the University Hospital Regensburg. We analyzed viral load by quantitative real-time polymerase chain reaction, viral antigen by point-of-care assay, time since onset of symptoms, and the presence of SARS-CoV-2 immunoglobulin G (IgG) antibodies in the context of virus isolation from respiratory specimens.
    Results: The odds ratio for virus isolation increased 1.9-fold for each log10 level of SARS-CoV-2 RNA and 7.4-fold with detection of viral antigen, while it decreased 6.3-fold beyond 10 days of symptoms and 20.0-fold with the presence of SARS-CoV-2 antibodies. The latter was confirmed for B.1.1.7 strains. The positive predictive value for virus isolation was 60.0% for viral loads >107 RNA copies/mL and 50.0% for the presence of viral antigen. Symptom onset before 10 days and seroconversion predicted lack of infectivity with negative predictive values of 93.8% and 96.0%.
    Conclusions: Our data support quarantining patients with high viral load and detection of viral antigen and lifting restrictive measures with increasing time to symptom onset and seroconversion. Delay of antibody formation may prolong infectivity.
    MeSH term(s) Adult ; Antibodies, Viral ; Antigens, Viral ; COVID-19/diagnosis ; COVID-19/immunology ; Female ; Humans ; Male ; Public Health ; RNA, Viral ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/pathogenicity ; Seroconversion ; Severity of Illness Index ; Viral Load
    Chemical Substances Antibodies, Viral ; Antigens, Viral ; RNA, Viral
    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab415
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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