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  1. Article ; Online: Optic nerve and macular optical coherence tomography in recovered COVID-19 patients.

    Burgos-Blasco, Barbara / Güemes-Villahoz, Noemi / Vidal-Villegas, Beatriz / Martinez-de-la-Casa, Jose Maria / Donate-Lopez, Juan / Martín-Sánchez, Francisco Javier / González-Armengol, Juan Jorge / Porta-Etessam, Jesus / Martin, Jose Luis R / Garcia-Feijoo, Julian

    European journal of ophthalmology

    2021  Volume 32, Issue 1, Page(s) 628–636

    Abstract: ... including macular and optic nerve optical coherence tomography. In the case group, socio-demographic data ... included; 90 recovered COVID-19 patients and 70 controls. COVID-19 patients presented increases in global ... RNFLT, ganglion cell layer (GCL), and inner plexiform layer (IPL) thickness in recovered COVID-19 ...

    Abstract Purpose: To investigate the peripapillary retinal nerve fiber layer thickness (RNFLT), macular RNFLT, ganglion cell layer (GCL), and inner plexiform layer (IPL) thickness in recovered COVID-19 patients compared to controls.
    Methods: Patients previously diagnosed with COVID-19 were included, while healthy patients formed the historic control group. All patients underwent an ophthalmological examination, including macular and optic nerve optical coherence tomography. In the case group, socio-demographic data, medical history, and neurological symptoms were collected.
    Results: One hundred sixty patients were included; 90 recovered COVID-19 patients and 70 controls. COVID-19 patients presented increases in global RNFLT (mean difference 4.3; CI95% 0.8 to 7.7), nasal superior (mean difference 6.9; CI95% 0.4 to 13.4), and nasal inferior (mean difference 10.2; CI95% 2.4 to 18.1) sectors of peripapillary RNFLT. Macular RNFL showed decreases in COVID-19 patients in volume (mean difference -0.05; CI95% -0.08 to -0.02), superior inner (mean difference -1.4; CI95% -2.5 to -0.4), nasal inner (mean difference -1.1; CI95% -1.8 to -0.3), and nasal outer (mean difference -4.7; CI95% -7.0 to -2.4) quadrants. COVID-19 patients presented increased GCL thickness in volume (mean difference 0.04; CI95% 0.01 to 0.07), superior outer (mean difference 2.1; CI95% 0.8 to 3.3), nasal outer (mean difference 2.5; CI95% 1.1 to 4.0), and inferior outer (mean difference1.2; CI95% 0.1 to 2.4) quadrants. COVID-19 patients with anosmia and ageusia presented an increase in peripapillary RNFLT and macular GCL compared to patients without these symptoms.
    Conclusions: SARS-CoV-2 may affect the optic nerve and cause changes in the retinal layers once the infection has resolved.
    MeSH term(s) COVID-19 ; Humans ; Nerve Fibers ; Optic Nerve ; Retinal Ganglion Cells ; SARS-CoV-2 ; Tomography, Optical Coherence
    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721211001019
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    Zs.A 3342: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Assessment of the optic nerve, macular, and retinal vascular effects of COVID-19.

    Ugurlu, Adem / Agcayazi, Sümeyye Burcu / Icel, Erel / Budakoglu, Ozlem / Unver, Edhem / Barkay, Orçun / Karakeçili, Faruk / Bayrakceken, Kemal

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2022  Volume 58, Issue 6, Page(s) 570–576

    Abstract: ... by optical coherence tomography angiography.: Results: In all quadrants, the RNFL and GCC were thinner in patients ... regions significantly differed between patients with and without COVID-19 symptoms (p > 0.05). The foveal ... optical coherence tomography analysis. The vessel densities of the superficial and deep capillary plexuses of the macula ...

    Abstract Objective: To evaluate the effects of SARS-CoV-2 infection on the optic nerve, macula, and retinal vascular structures.
    Methods: This study included 129 participants recovering from COVID-19 and 130 healthy control subjects aged 18 to 55 years. The study was designed as observational and cross-sectional and was conducted between June 2020 and February 2021. The average thicknesses of the retinal nerve fibre layer (RNFL), ganglion cell complex (GCC), and macula also were measured using a spectral domain optical coherence tomography analysis. The vessel densities of the superficial and deep capillary plexuses of the macula, foveal avascular zone, and radial peripapillary capillary plexus of the optic disc were quantified by optical coherence tomography angiography.
    Results: In all quadrants, the RNFL and GCC were thinner in patients with neurologic symptoms of COVID-19 (p < 0.05). None of the measurements of the Early Treatment Diabetic Retinopathy Study regions significantly differed between patients with and without COVID-19 symptoms (p > 0.05). The foveal avascular zone area, perimeter, circularity index, and vessel densities (%) of the global and inner and outer circles of superficial capillary plexuses and deep capillary plexus and global and superior and inferior halves of the radial peripapillary capillary plexus measurements were found to significantly differ between the symptomatic COVID-19 group and the asymptomatic COVID-19 and control groups (p < 0.05).
    Conclusion: RNFL and GCC thickness evaluation with optical coherence tomography and vessel density evaluation with optical coherence tomography angiography can be considered remarkable diagnostic methods for retinal neurovascular abnormalities and a biomarker for microvascular abnormalities after infection with SARS-CoV-2.
    MeSH term(s) Humans ; COVID-19 ; Cross-Sectional Studies ; Fluorescein Angiography/methods ; Optic Disk/blood supply ; Retinal Vessels ; SARS-CoV-2 ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2022-06-30
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2022.06.016
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    Zs.A 588: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Evaluation of acute effects of pulmonary involvement and hypoxia on retina and choroid in coronavirus disease 2019: An optic coherence tomography study.

    Güven, Yusuf Ziya / Kıratlı, Kazım / Kahraman, Hazan Gül / Akay, Fahrettin / Yurdakul, Eray Serdar

    Photodiagnosis and photodynamic therapy

    2022  Volume 41, Page(s) 103265

    Abstract: ... optic coherence tomography.: Methods: This prospective case-control study included COVID-19 patients: 50 with pulmonary ... retinal and optic nerve diseases in the future. Therefore, COVID-19 patients with pulmonary involvement ... from COVID-19. The changes were followed using optic coherence tomography parameters such as choroidal and ...

    Abstract Purpose: We investigated the acute subclinical choroidal and retinal changes caused by Coronavirus Disease 2019 (COVID-19) in patients with and without pulmonary involvement, using spectral domain optic coherence tomography.
    Methods: This prospective case-control study included COVID-19 patients: 50 with pulmonary involvement and 118 with non-pulmonary involvement. All patients were examined 1 month after recovering from COVID-19. The changes were followed using optic coherence tomography parameters such as choroidal and macular thickness and retinal nerve fibre layer and ganglion cell complex measurements.
    Results: All choroidal thicknesses in the pulmonary involvement group were lower than in the non-pulmonary involvement group and the subfoveal choroidal thickness differed significantly (p=0.036). Although there were no significant differences between the central and average macular thicknesses in the two groups, they were slightly thicker in the pulmonary involvement group (p=0.152 and p=0.180, respectively). A significant decrease was detected in the pulmonary involvement group in all ganglion cell complex segments, except for the outer nasal inferior segment (p<0.05). In addition, a thinning tendency was observed in all retinal nerve fibre layer quadrants in the pulmonary involvement group compared to the non-pulmonary involvement group.
    Conclusion: In COVID-19 patients with pulmonary involvement, subclinical choroidal and retinal changes may occur due to hypoxia and ischemia in the acute period. These patients may be predisposed to ischemic retinal and optic nerve diseases in the future. Therefore, COVID-19 patients with pulmonary involvement should be followed for ophthalmological diseases.
    MeSH term(s) Humans ; Retinal Ganglion Cells ; Case-Control Studies ; Tomography, Optical Coherence/methods ; COVID-19/complications ; Photochemotherapy/methods ; Photosensitizing Agents ; Retina ; Choroid/diagnostic imaging ; Hypoxia
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2022-12-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2022.103265
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  4. Article ; Online: SD-OCT assessment of macular and optic nerve alterations in patients recovered from COVID-19.

    Mavi Yildiz, Aysegul / Ucan Gunduz, Gamze / Yalcinbayir, Ozgur / Acet Ozturk, Nilufer Aylin / Avci, Remzi / Coskun, Funda

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2021  Volume 57, Issue 2, Page(s) 75–81

    Abstract: ... nerve fibre layer (RNFL) in patients recovered from coronavirus disease 2019 (COVID-19) using spectral domain ... cross-sectional study included patients who recovered from COVID-19 (Group 1) and age- and sex-matched normal ... Significant thickness alterations in individual retinal layers and CFT was detected in post-COVID-19 patients ...

    Abstract Objective: To quantify microstructutal alterations in the macula and peripapillary retinal nerve fibre layer (RNFL) in patients recovered from coronavirus disease 2019 (COVID-19) using spectral domain optic coherence tomography (SD-OCT).
    Design: Retrospective, observational.
    Participants: This comparative, cross-sectional study included patients who recovered from COVID-19 (Group 1) and age- and sex-matched normal controls (Group 2).
    Methods: A comprehensive ophthalmic examination, including best-corrected visual acuity and biomicroscopic anterior and posterior segment examination was performed. SD-OCT analysis of the macula and peripapillary RNFL was obtained for each participant. In addition, patient demographics and comorbidities were recorded.
    Results: 238 eyes of 122 subjects (Group 1: n = 63; Group 2: n = 59) were included. The incidence of coexisting comorbidity was higher in Group 1 (n = 26/63, 41.3%) compared with Group 2 (n = 12/59, 20.3%) (p = 0.013). The central foveal thickness (CFT) was significantly higher in Group 1 (271.0±26.8 µm) than Group 2 (263.2±22.0 µm) (p = 0.015). The average outer nuclear layer (ONL) thickness at central fovea in Group 1 (85.4±13.3 µm) was significantly thicker than that in Group 2 (81.4±15.2 µm) (p = 0.035). The mean peripapillary RNFL thickness of Group 1 (102.6±8.8 µm) and Group 2 (100.9±8.3 µm) were similar (p = 0.145). The mean choroidal thickness of groups at the fovea and at 1500 µm nasal and temporal to the fovea were not significantly different (p > 0.05 for all).
    Conclusion: Significant thickness alterations in individual retinal layers and CFT was detected in post-COVID-19 patients. The increase in CFT and ONL thickness might be attributed to direct infection or viral-induced inflammatory response of retina.
    MeSH term(s) COVID-19/epidemiology ; Cross-Sectional Studies ; Humans ; Nerve Fibers ; Optic Disk ; Optic Nerve ; Retinal Ganglion Cells ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Visual Acuity
    Language English
    Publishing date 2021-07-05
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2021.06.019
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Assessment of early and long-COVID related retinal neurodegeneration with optical coherence tomography.

    Dağ Şeker, Esra / Erbahçeci Timur, İnci Elif

    International ophthalmology

    2022  Volume 43, Issue 6, Page(s) 2073–2081

    Abstract: ... 19 disease (COVID-19) at inner and outer retinal layers of patients recovered from COVID-19 ... Twenty-seven patients recovered from COVID-19, and age- and gender-matched 27 healthy controls were ... with Spectral Domain Optical Coherence Tomography (SD-OCT) and compare these to healthy subjects.: Methods ...

    Abstract Purpose: The aim of this study is to investigate short-term and long-term effects of coronovirus 19 disease (COVID-19) at inner and outer retinal layers of patients recovered from COVID-19 with Spectral Domain Optical Coherence Tomography (SD-OCT) and compare these to healthy subjects.
    Methods: Twenty-seven patients recovered from COVID-19, and age- and gender-matched 27 healthy controls were included in this study. Macular and peripapillary retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), inner nuclear layer (INL), outer plexiform layer (OPL) and outer nuclear layer (ONL) were analyzed with SD-OCT 1 month (V
    Results: Macular RNFL thickness in outer ring was thinner at V
    Conclusion: Subclinical localized changes in macular and peripapillary RNFL and outer nuclear layer were demonstrated in early and 12-months follow-up after COVID-19 recovery.
    MeSH term(s) Humans ; Tomography, Optical Coherence/methods ; Retinal Ganglion Cells ; Post-Acute COVID-19 Syndrome ; Nerve Fibers ; COVID-19/complications
    Language English
    Publishing date 2022-12-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-022-02607-9
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    Zs.A 1479: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: COVID-19: more than a respiratory virus, an optical coherence tomography study.

    Dag Seker, Esra / Erbahceci Timur, Inci Elif

    International ophthalmology

    2021  Volume 41, Issue 11, Page(s) 3815–3824

    Abstract: ... and outer retinal layers in patients recovered from COVID-19 with Spectral Domain ... Optical Coherence Tomography (SD-OCT), whether correlate with any symptoms during disease process.: Methods: 32 patients ... recovered from COVID-19 and age- and gender-matched 36 healthy controls were included ...

    Abstract Purpose: The purpose of this study is to investigate anatomic and morphologic features of inner and outer retinal layers in patients recovered from COVID-19 with Spectral Domain Optical Coherence Tomography (SD-OCT), whether correlate with any symptoms during disease process.
    Methods: 32 patients recovered from COVID-19 and age- and gender-matched 36 healthy controls were included in this cross-sectional study. Ganglion cell-inner plexiform layer, macular and peripapiller retinal nerve fiber layer (RNFL), inner nuclear layer (INL), outer nuclear layer (ONL), outer plexiform layer (OPL) and the outer retinal hyperreflective bands including external limiting membrane (ELM), ellipsoid zone (EZ) and interdigitation zone (IZ) were examined with SD-OCT. The differences of each retinal layers thickness among subgroup analysis of ocular pain and headache were also compared.
    Results: Macular RNFL of inner and outer nasal and outer inferior quadrants were thinner in COVID-19 patients compared to healthy control group (p = 0.046, p = 0.014 and p = 0.016, respectively). Thinning in outer superior quadrant of GCIPL and INL quadrants were detected in patients with headache (p = 0.026 and p = 0.01). Superonasal and inferotemporal sectors of pRNFL were thinner in patients with ocular pain compared to patients without ocular pain (p = 0.024 and p = 0.015). Integrity of EZ, ELM and IZ was evaluated as continuous line and protected on each OCT scans.
    Conclusion: The study demonstrated convincing evidence that SARS-CoV-2 can affect the inner and outer retinal layers, with subclinical localized alterations, particularly in patients with headache and ocular pain symptoms during COVID-19 period.
    MeSH term(s) COVID-19 ; Cross-Sectional Studies ; Humans ; Nerve Fibers ; Retinal Ganglion Cells ; SARS-CoV-2 ; Tomography, Optical Coherence
    Language English
    Publishing date 2021-07-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-021-01952-5
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    Zs.A 1479: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Optical Coherence Tomography Angiography Features in Post-COVID-19 Pneumonia Patients: A Pilot Study.

    Cennamo, Gilda / Reibaldi, Michele / Montorio, Daniela / D'Andrea, Luca / Fallico, Matteo / Triassi, Maria

    American journal of ophthalmology

    2021  Volume 227, Page(s) 182–190

    Abstract: ... 19 patients had to be fully recovered from COVID-19 pneumonia and were evaluated 6 months after COVID ... regions in post-SARS-CoV-2 pneumonia patients by means of optical coherence tomography angiography (OCTA ... compared to those in healthy subjects (P <.05). COVID-19 patients featured a reduced VD of the RPC compared ...

    Abstract Purpose: This study investigated changes in retinal vessel density in macular and papillary regions in post-SARS-CoV-2 pneumonia patients by means of optical coherence tomography angiography (OCTA).
    Design: Prospective, observational, cohort study.
    Methods: Forty eyes of 40 patients (mean age: 49.7 ± 12.6 years old) post-SARS-CoV-2 infection and 40 healthy subjects were enrolled in this study. COVID-19 patients had to be fully recovered from COVID-19 pneumonia and were evaluated 6 months after COVID-19 infection. The primary outcome resulted from OCTA studies of the following vascular structures: vessel density (VD) in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and radial peripapillary capillaries (RPC) compared to those of controls. Structural spectral domain (SD)-OCT parameters were also evaluated: ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL).
    Results: The patients showed a significant reduction in VD of the SCP in whole images and in the DCP in all sectors compared to those in healthy subjects (P <.05). COVID-19 patients featured a reduced VD of the RPC compared to that in controls (P <.001). No differences were found in the GCC, whereas the RNFL was reduced in the COVID-19 group compared to that in controls (P = .012). Significant correlations were found between the RNFL and VD of the SCP, DCP, RPC, and FAZ area in the COVID-19 group (P <.05).
    Conclusions: OCTA showed retinal vascular changes in subjects fully recovered from COVID-19 pneumonia. These findings could be a consequence of a thrombotic microangiopathy that affected retinal structures as well as other systemic organs. OCTA could represent a valid, noninvasive biomarker of early vascular dysfunction after SARS-CoV-2 infection.
    MeSH term(s) COVID-19/epidemiology ; Capillaries/diagnostic imaging ; Comorbidity ; Female ; Fluorescein Angiography/methods ; Fundus Oculi ; Humans ; Macula Lutea/pathology ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Retinal Diseases/diagnosis ; Retinal Diseases/epidemiology ; Retinal Vessels/diagnostic imaging ; SARS-CoV-2 ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2021-03-27
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2021.03.015
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