Article ; Online: Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of Over 700 Healthcare Workers.
2021 Volume 46
Abstract: ... These data suggest a significant proportion of COVID-19 cases have persistent chemosensory impairments at 3-7 ... However, due to the great variability in published results regarding COVID-19-induced chemosensory impairments ... their prevalence and evolution after infection. A cross-sectional study of 704 healthcare workers with a RT-PCR ...
| Abstract | Several studies have revealed either self-reported chemosensory alterations in large groups or objective quantified chemosensory impairments in smaller populations of patients diagnosed with COVID-19. However, due to the great variability in published results regarding COVID-19-induced chemosensory impairments and their follow-up, prognosis for chemosensory functions in patients with such complaints remains unclear. Our objective is to describe the various chemosensory alterations associated with COVID-19 and their prevalence and evolution after infection. A cross-sectional study of 704 healthcare workers with a RT-PCR-confirmed SARS-CoV-2 infection between 2020 February 28 and 2020 June 14 was conducted 3-7 months after onset of symptoms. Data were collected with an online questionnaire. Outcomes included differences in reported chemosensory self-assessment of olfactory, gustatory, and trigeminal functions across time points and Chemosensory Perception Test scores from an easy-to-use at-home self-administered chemosensory test. Among the 704 participants, 593 (84.2%) were women, the mean (SD) age was 42 (12) years, and the questionnaire was answered on average 4.8 (0.8) months after COVID-19. During COVID-19, a decrease in olfactory, gustatory, and trigeminal sensitivities was reported by 81.3%, 81.5%, and 48.0%, respectively. Three to 7 months later, reduced sensitivity was still reported by 52.0%, 41.9%, and 23.3%, respectively. Chemosensory Perception Test scores indicate that 19.5% of participants had objective olfactory impairment. These data suggest a significant proportion of COVID-19 cases have persistent chemosensory impairments at 3-7 months after their infection, but the majority of those who had completely lost their olfactory, gustatory, and trigeminal sensitivities have improved. |
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| MeSH term(s) | Adolescent ; Adult ; Aged ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/etiology ; Health Personnel ; Humans ; Male ; Middle Aged ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Prevalence ; Self Report ; Surveys and Questionnaires ; Taste Disorders/epidemiology ; Taste Disorders/etiology ; Time Factors | |||||
| Language | English | |||||
| Publishing date | 2021-08-22 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 754122-3 | |||||
| ISSN | 1464-3553 ; 0379-864X | |||||
| ISSN (online) | 1464-3553 | |||||
| ISSN | 0379-864X | |||||
| DOI | 10.1093/chemse/bjab038 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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