Article ; Online: Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis.
International journal of molecular sciences
2020 Volume 21, Issue 10
Abstract: Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted ... This review summarizes some of the most important molecules and interactions within lung surfactant and how ... multiple lipid-protein and protein-protein interactions contribute to the proper maintenance ...
| Abstract | Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and secreted into the airspaces, where it coats and protects the large respiratory air-liquid interface. Surfactant, assembled as a complex network of membranous structures, integrates elements in charge of reducing surface tension to a minimum along the breathing cycle, thus maintaining a large surface open to gas exchange and also protecting the lung and the body from the entrance of a myriad of potentially pathogenic entities. Different molecules in the surfactant establish a multivalent crosstalk with the epithelium, the immune system and the lung microbiota, constituting a crucial platform to sustain homeostasis, under health and disease. This review summarizes some of the most important molecules and interactions within lung surfactant and how multiple lipid-protein and protein-protein interactions contribute to the proper maintenance of an operative respiratory surface. |
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| MeSH term(s) | Alveolar Epithelial Cells/metabolism ; Alveolar Epithelial Cells/microbiology ; Alveolar Epithelial Cells/physiology ; Animals ; Homeostasis ; Humans ; Lipid Metabolism ; Pulmonary Surfactant-Associated Proteins/metabolism |
| Chemical Substances | Pulmonary Surfactant-Associated Proteins |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-25 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2019364-6 |
| ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
| ISSN (online) | 1422-0067 |
| ISSN | 1422-0067 ; 1661-6596 |
| DOI | 10.3390/ijms21103708 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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