Article ; Online: High body mass index is a significant risk factor for the progression and prognosis of imported COVID-19: a multicenter, retrospective cohort study.
2021 Volume 21, Issue 1, Page(s) 147
Abstract: ... to characterize the clinical features and outcomes of imported COVID-19 patients with high body mass index (BMI ... cohort study, 455 imported COVID-19 patients were admitted and discharged in Zhejiang province by February 28 ... hospitalization duration and anti-virus course. Thus, high BMI is a risk factor for the progression and prognosis ...
| Abstract | Background: Coronavirus disease 2019(COVID-19) has spread worldwide. The present study aimed to characterize the clinical features and outcomes of imported COVID-19 patients with high body mass index (BMI) and the independent association of BMI with disease severity. Methods: In this retrospective cohort study, 455 imported COVID-19 patients were admitted and discharged in Zhejiang province by February 28, 2020. Epidemiological, demographic, clinical, laboratory, radiological, treatment, and outcome data were collected, analyzed and compared between patients with BMI ≥ 24and < 24. Results: A total of 268 patients had BMI < 24, and 187 patients had BMI ≥ 24. Those with high BMI were mostly men, had a smoking history, fever, cough, and sputum than those with BMI < 24. A large number of patients with BMI ≥ 24 were diagnosed as severe/critical types. Some biochemical indicators were significantly elevated in patients with BMI ≥ 24. Also, acute liver injury was the most common complication in these patients. The median days from illness onset to severe acute respiratory syndrome coronavirus 2 detection, duration of hospitalization, and days from illness onset to discharge were significantly longer in patients with BMI ≥ 24 than those with BMI < 24. High BMI, exposure to Wuhan, any coexisting medical condition, high temperature, C-reactive protein (CRP), and increased lactate dehydrogenase (LDH) were independent risk factors for severe/critical COVID-19. After adjusting for age, sex and above factors, BMI was still independently associated with progression to severe/critical illness (P = 0.0040). Hemoglobin, alanine aminotransferase (ALT), CRP, and serum creatinine (Scr) were independent risk factors associated with high BMI. Conclusions: Contrasted with the imported COVID-19 patients with BMI < 24, high proportion of COVID-19 patients with BMI ≥ 24 in our study, especially those with elevated CRP and LDH, developed to severe type, with longer hospitalization duration and anti-virus course. Thus, high BMI is a risk factor for the progression and prognosis of imported COVID-19. |
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| MeSH term(s) | Adult ; Body Mass Index ; COVID-19/epidemiology ; COVID-19/etiology ; China/epidemiology ; Cohort Studies ; Disease Progression ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 |
| Language | English |
| Publishing date | 2021-02-05 |
| Publishing country | England |
| Document type | Journal Article ; Multicenter Study |
| ZDB-ID | 2041550-3 |
| ISSN | 1471-2334 ; 1471-2334 |
| ISSN (online) | 1471-2334 |
| ISSN | 1471-2334 |
| DOI | 10.1186/s12879-021-05818-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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