Article ; Online: Impact of the COVID-19 pandemic on in-hospital mortality in cardiovascular disease: a meta-analysis.
European journal of preventive cardiology
2021 Volume 29, Issue 8, Page(s) 1266–1274
Abstract: ... the COVID-19 pandemic, the pooled risk ratio (RR) demonstrated increased in-hospital mortality by 62% during ... 50% during the COVID-19 pandemic observed the greatest increase in mortality compared ... Aims: The COVID-19 pandemic has resulted in excess mortality due to both COVID-19 directly and ...
| Abstract | Aims: The COVID-19 pandemic has resulted in excess mortality due to both COVID-19 directly and other conditions, including cardiovascular (CV) disease. We aimed to explore the excess in-hospital mortality, unrelated to COVID-19 infection, across a range of CV diseases. Methods and results: A systematic search was performed for studies investigating in-hospital mortality among patients admitted with CV disease without SARS-CoV-2 infection compared with a period outside the COVID-19 pandemic. Fifteen studies on 27 421 patients with CV disease were included in the analysis. The average in-hospital mortality rate was 10.4% (n = 974) in the COVID-19 group and 5.7% (n = 1026) in the comparator group. Compared with periods outside the COVID-19 pandemic, the pooled risk ratio (RR) demonstrated increased in-hospital mortality by 62% during COVID-19 [95% confidence interval (CI) 1.20-2.20, P = 0.002]. Studies with a decline in admission rate >50% during the COVID-19 pandemic observed the greatest increase in mortality compared with those with <50% reduction [RR 2.74 (95% CI 2.43-3.10) vs. 1.21 (95% CI 1.07-1.37), P < 0.001]. The observed increased mortality was consistent across different CV conditions (P = 0.74 for interaction). Conclusions: In-hospital mortality among patients admitted with CV diseases was increased relative to periods outside the pandemic, independent of co-infection with COVID-19. This effect was larger in studies with the biggest decline in admission rates, suggesting a sicker cohort of patients in this period. However, studies were generally poorly conducted, and there is a need for further well-designed studies to establish the full extent of mortality not directly related to COVID-19 infection. |
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| MeSH term(s) | COVID-19 ; Cardiovascular Diseases/diagnosis ; Hospital Mortality ; Humans ; Pandemics ; SARS-CoV-2 |
| Language | English |
| Publishing date | 2021-07-23 |
| Publishing country | England |
| Document type | Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2626011-6 |
| ISSN | 2047-4881 ; 2047-4873 |
| ISSN (online) | 2047-4881 |
| ISSN | 2047-4873 |
| DOI | 10.1093/eurjpc/zwab119 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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